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Protein Page:
NRF2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NRF2 a transcription factor that regulates basal expression and antioxidant induction of a transcription factor for NAD(P)H:quinone oxidoreductase-1 (NQO1) and other detoxifying genes. Targeted for proteasomal degradation by INrf2. Oxidative stress causes its phosphorylation and release from INrf2. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: centrosome; cytoplasm; plasma membrane; chromatin; cytosol; nucleus
Molecular Function: protein domain specific binding; protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; positive regulation of blood coagulation; unfolded protein response; regulation of embryonic development; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q16236 (UniProtKB)
Alt. Names/Synonyms: HEBP1; NF-E2-related factor 2; NF2L2; NFE2-related factor 2; NFE2L2; NRF2; nuclear factor (erythroid-derived 2)-like 2; Nuclear factor erythroid 2-related factor 2; Nuclear factor, erythroid derived 2, like 2
Gene Symbols: NFE2L2
Molecular weight: 67,826 Da
Basal Isoelectric point: 4.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NRF2

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S215‑p, S408‑p, S558‑p, T559‑p, S577‑p
intracellular localization: S215‑p, S408‑p, S558‑p, T559‑p, S577‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
9 0 S40-p SREVFDFsQRRkEYE
0 1 K44-u FDFsQRRkEYELEKQ
0 1 K64-u ERQEQLQkEQEKAFF
1 3 S215-p VETTMVPsPEAKLTE
3 0 S344-p AEFNDSDsGIsLNTs
3 0 S347-p NDSDsGIsLNTsPSV
2 0 S351-p sGIsLNTsPSVAsPE
2 0 S356-p NTsPSVAsPEHSVES
1 0 S360 SVAsPEHSVESSSYG
1 0 S364 PEHSVESSSYGDTLL
1 1 S408-p GDMVQPLsPSQGQST
1 0 K438-a PVSPGHRkTPFTkDk
1 0 K443-a HRkTPFTkDkHSSRL
1 0 K445-a kTPFTkDkHSSRLEA
1 0 K462-a TRDELRAkALHIPFP
1 0 K472-a HIPFPVEkIINLPVV
1 0 K487-a DFNEMMSkEQFNEAQ
1 0 K506-a RDIRRRGkNkVAAQN
1 0 K508-a IRRRGkNkVAAQNCR
1 0 K516-a VAAQNCRkRkLENIV
1 0 K518-a AQNCRkRkLENIVEL
1 0 K533-a EQDLDHLkDEkEkLL
1 0 K536-a LDHLkDEkEkLLkEk
1 0 K538-a HLkDEkEkLLkEkGE
1 0 K541-a DEkEkLLkEkGENDk
1 0 K543-a kEkLLkEkGENDkSL
1 0 K548-a kEkGENDkSLHLLkk
1 0 K554-a DkSLHLLkkQLstLy
1 0 K555-a kSLHLLkkQLstLyL
1 1 S558-p HLLkkQLstLyLEVF
1 1 T559-p LLkkQLstLyLEVFS
0 2 Y561-p kkQLstLyLEVFSML
4 1 Y576-p RDEDGKPysPSEYSL
1 1 S577-p DEDGKPysPSEYSLQ
1 0 K596-a GNVFLVPkSKkPDVK
1 0 K599-a FLVPkSKkPDVKKN_
  mouse

 
S40-p SREVFDFsQRQKDYE
K44 FDFsQRQKDYELEKQ
K64 ERQEQLQKEQEKAFF
S207 ADTTAVPSPEATLTE
S335-p MEFNDSDsGIsLNTs
S338-p NDSDsGIsLNTsPSR
S342-p sGIsLNTsPSRAsPE
S347-p NTsPSRAsPEHsVES
S351-p SRAsPEHsVESsIYG
S355-p PEHsVESsIYGDPPP
S400-p GDTVQPLsPAQGHSA
K430 PVSPGHQKAPFTKDK
K435 HQKAPFTKDKHSSRL
K437 KAPFTKDKHSSRLEA
K454 TRDELRAKALHIPFP
K464 HIPFPVEKIINLPVD
K479 DFNEMMSKEQFNEAQ
K498 RDIRRRGKNKVAAQN
K500 IRRRGKNKVAAQNCR
K508 VAAQNCRKRKLENIV
K510 AQNCRKRKLENIVEL
K525 EQDLGHLKDEREKLL
R528 LGHLKDEREKLLREK
K530 HLKDEREKLLREKGE
R533 DEREKLLREKGENDR
K535 REKLLREKGENDRNL
R540 REKGENDRNLHLLKR
K546 DRNLHLLKRRLSTLY
R547 RNLHLLKRRLSTLYL
S550 HLLKRRLSTLYLEVF
T551 LLKRRLSTLYLEVFS
Y553 KRRLSTLYLEVFSML
Y568-p RDEDGKPySPSEYSL
S569 DEDGKPySPSEYSLQ
K588 GNVFLVPKSKKPDTK
K591 FLVPKSKKPDTKKN_
  rat

 
S40-p SREVFDFsQRQKDYE
K44 FDFsQRQKDYELEKQ
K64 ERQEQLQKEQEKAFF
S214 AETTTVPSPEATLTE
S342 VEFNDSDSGISLNTS
S345 NDSDSGISLNTSPSR
S349 SGISLNTSPSRASPE
S354 NTSPSRASPEHSVES
S358 SRASPEHSVESSIYG
S362 PEHSVESSIYGDPPP
S407 GDTVQPLSPAQGHSA
K437 PVSPGHQKVPFTKDK
K442 HQKVPFTKDKHSSRL
K444 KVPFTKDKHSSRLEA
K461 TRDELRAKALHIPFP
K471 HIPFPVEKIINLPVD
K486 DFNEMMSKEQFNEAQ
K505 RDIRRRGKNKVAAQN
K507 IRRRGKNKVAAQNCR
K515 VAAQNCRKRKLENIV
K517 AQNCRKRKLENIVEL
K532 EQDLGHLKDEREKLL
R535 LGHLKDEREKLLREK
K537 HLKDEREKLLREKGE
R540 DEREKLLREKGENDR
K542 REKLLREKGENDRNL
R547 REKGENDRNLHLLKR
K553 DRNLHLLKRKLSTLY
R554 RNLHLLKRKLSTLYL
S557 HLLKRKLSTLYLEVF
T558 LLKRKLSTLYLEVFS
Y560 KRKLSTLYLEVFSML
Y575 RDEDGKPYSPSEYSL
S576 DEDGKPYSPSEYSLQ
K595 GNVFLVPKSKKPDTK
K598 FLVPKSKKPDTKKN_
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