Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
perilipin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
perilipin an adipocyte protein of the peripilin family. A modulator of adipocyte lipid metabolism, coating lipid storage droplets to protect them from being broken down by hormone-sensitive lipase. A major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis. Note: This description may include information from UniProtKB.
Protein type: Lipid binding protein
Cellular Component: endoplasmic reticulum; lipid particle
Molecular Function: lipid binding
Biological Process: triacylglycerol catabolic process; lipid metabolic process
Reference #:  O60240 (UniProtKB)
Alt. Names/Synonyms: Lipid droplet-associated protein; PERI; perilipin 1; Perilipin-1; PLIN; PLIN1
Gene Symbols: PLIN1
Molecular weight: 55,990 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

perilipin

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T40-p TCECFQKtYTSTKEA
0 1 S53-p EAHPLVAsVCNAyEK
0 1 Y58-p VAsVCNAyEKGVQSA
0 1 S72 ASSLAAWSMEPVVRR
2 18 S81-p EPVVRRLsTQFtAAN
0 4 T82 PVVRRLsTQFtAANE
0 4 T85-p RRLsTQFtAANELAC
0 1 S114 YPPEKIASELKDTIS
0 9 S126-p TISTRLRsARNsISV
0 12 S130-p RLRsARNsISVPIAS
0 2 S132 RsARNsISVPIASTS
0 1 S137 sISVPIASTSDKVLG
0 10 S174-p TRAGRLAsGGADLAL
0 1 S183 GADLALGSIEKVVEY
0 1 P203 KEESAPAPGHQQAQK
2 6 G223 PSLLSRVGALTNTLS
0 4 A224 SLLSRVGALTNTLSR
0 1 T228 RVGALTNTLSRYTVQ
2 0 S277 QAVSRRRSEVRVPWL
0 1 D294 LAAAQEEDHEDQtDt
0 2 T299-p EEDHEDQtDtEGEDt
0 2 T301-p DHEDQtDtEGEDtEE
0 2 T306-p tDtEGEDtEEEEELE
0 1 L312 DtEEEEELETEENKF
0 1 T346 LQKTLQTTISAVTWA
0 1 K377 APAVSSTKGRAMsLs
0 8 S382-p STKGRAMsLsDALKG
0 2 S384-p KGRAMsLsDALKGVT
0 1 Y401-p VVDTVVHyVPLPRLS
0 5 S408 yVPLPRLSLMEPESE
0 1 P423 FRDIDNPPAEVERRE
0 1 R429 PPAEVERREAERRAs
0 3 S436-p REAERRAsGAPSAGP
0 4 G442 AsGAPSAGPEPAPRL
0 1 P445 APSAGPEPAPRLAQP
0 1 A446 PSAGPEPAPRLAQPR
0 1 S455 RLAQPRRSLRSAQSP
0 2 Q460 RRSLRSAQSPGAPPG
0 3 G463 LRSAQSPGAPPGPGL
0 1 P466 AQSPGAPPGPGLEDE
0 1 V474 GPGLEDEVATPAAPR
7 3 S497-p EKPKRRVsDSFFRPS
0 1 S499 PKRRVsDSFFRPSVM
0 1 S504 sDSFFRPSVMEPILG
0 1 Y515-p PILGRTHysQLRKKs
0 2 S516-p ILGRTHysQLRKKs_
6 1 S522-p ysQLRKKs_______
  mouse

 
T40 TCECFQKTYNSTKEA
S53 EAHPLVASVCNAYEK
Y58 VASVCNAYEKGVQGA
S72-p ASNLAAWsMEPVVRR
S81-p EPVVRRLstQFtAAN
T82-p PVVRRLstQFtAANE
T85-p RRLstQFtAANELAC
S114-p YPPEKIAsELKGTIS
S126-p TISTRLRsARNsIsV
S130-p RLRsARNsIsVPIAs
S132-p RsARNsIsVPIAsTS
S137-p sIsVPIAsTSDKVLG
S174-p TRVGRLAsGGADLAL
S183-p GADLALGsIEKVVEF
S202-p DKESAPSsGRQRTQK
S222-p PSLVRRVstLANtLS
T223-p SLVRRVstLANtLSR
T227-p RVstLANtLSRHTMQ
S276-p QVVSRRQsEVRVPWL
S293-p LAASQDEsHDDQtDt
T298-p DEsHDDQtDtEGEEt
T300-p sHDDQtDtEGEEtDD
T305-p tDtEGEEtDDEEEEE
S314-p DEEEEEEsEAEENVL
T348-p VQNTLRNtISAVTWA
K379-ub AQAVSSTkGRAMsLs
S384-p STkGRAMsLsDALKG
S386-p kGRAMsLsDALKGVT
Y403 VVDTVVHYVPLPRLs
S410-p YVPLPRLsLMEPESE
S425-p FRDIDNPsAEAERkG
K431-ac PsAEAERkGsGARPA
S433-p AEAERkGsGARPAsP
S439-p GsGARPAsPEstPRP
S442-p ARPAsPEstPRPGQP
T443-p RPAsPEstPRPGQPR
S452-p RPGQPRGsLRSVrGL
R457-m1 RGsLRSVrGLsAPsC
S460-p LRSVrGLsAPsCPGL
S463-p VrGLsAPsCPGLDDK
T471-p CPGLDDKtEASARPG
S492-p EKPARRVsDsFFRPs
S494-p PARRVsDsFFRPsVM
S499-p sDsFFRPsVMEPILG
Y510 PILGRAQYsQLRKKs
S511-p ILGRAQYsQLRKKs_
S517-p YsQLRKKs_______
  rat

► Hide Isoforms
 
T40 TCECFQKTYNSTKEA
S53 EAHPLVASVCNAYEK
Y58 VASVCNAYEKGVQGA
S72 ASNLAAWSMEPVVRR
S81-p EPVVRRLsTQFTAAN
T82 PVVRRLsTQFTAANE
T85 RRLsTQFTAANELAC
S114 YPPEKIASELKGTIS
S126-p TISTRLRsARNsISV
S130-p RLRsARNsISVPIAS
S132 RsARNsISVPIASTS
S137 sISVPIASTSDKVLG
S174-p TRVGRLAsGGADLAL
S183 GADLALGSIEKVVEY
S203 KVESAPSSGRQKTQK
S223-p PSLLRRVstLANTLS
T224-p SLLRRVstLANTLSR
T228 RVstLANTLSRHTMQ
S277-p QVVSRRQsEVRVPWL
N294 LAASKDENHEDQtDt
T299-p DENHEDQtDtEGEEt
T301-p NHEDQtDtEGEEtDE
T306-p tDtEGEEtDEEEEEE
S315-p EEEEEEEsEAEENVL
T349 VQKTLQNTISAVTWA
K380 AQAVSSTKGRAMsLs
S385-p STKGRAMsLsDALKG
S387-p KGRAMsLsDALKGVT
Y404 VVDTVVHYVPLPRLs
S411-p YVPLPRLsLMEPESE
P426 FQDIDNPPAEVERKG
K432 PPAEVERKGsGSRPA
S434-p AEVERKGsGSRPAsP
S440-p GsGSRPAsPESTARP
S443 SRPAsPESTARPGQP
T444 RPAsPESTARPGQPR
A452 ARPGQPRAACAVRGL
R457 PRAACAVRGLsAPSC
S460-p ACAVRGLsAPSCPDL
S463 VRGLsAPSCPDLDDK
T471 CPDLDDKTETSARPG
S492-p EKPARRVsDSFFRPS
S494 PARRVsDSFFRPSVM
S499 sDSFFRPSVMEPILG
Y510 PILGRTQYSQLRKKS
S511 ILGRTQYSQLRKKS_
S517 YSQLRKKS_______
  perilipin iso2  
T40 TCECFQKTYNSTKEA
S53 EAHPLVASVCNAYEK
Y58 VASVCNAYEKGVQGA
S72 ASNLAAWSMEPVVRR
S81 EPVVRRLSTQFTAAN
T82 PVVRRLSTQFTAANE
T85 RRLSTQFTAANELAC
S114 YPPEKIASELKGTIS
S126 TISTRLRSARNSISV
S130 RLRSARNSISVPIAS
S132 RSARNSISVPIASTS
S137 SISVPIASTSDKVLG
S174 TRVGRLASGGADLAL
S183 GADLALGSIEKVVEY
S203 KVESAPSSGRQKTQK
S223 PSLLRRVSTLANTLS
T224 SLLRRVSTLANTLSR
T228 RVSTLANTLSRHTMQ
S277 QVVSRRQSEVRVPWL
N294 LAASKDENHEDQTDT
T299 DENHEDQTDTEGEET
T301 NHEDQTDTEGEETDE
T306 TDTEGEETDEEEEEE
S315 EEEEEEESEAEENVL
T349 VQKTLQNTISAVTWA
K380 AQAVSSTKGRAMSLS
S385 STKGRAMSLSDALKG
S387 KGRAMSLSDALKGVT
Y404 VVDTVVHYVPVSPAP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.