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Protein Page:
perilipin (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
perilipin an adipocyte protein of the peripilin family. A modulator of adipocyte lipid metabolism, coating lipid storage droplets to protect them from being broken down by hormone-sensitive lipase. A major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis. Note: This description may include information from UniProtKB.
Protein type: Lipid binding protein
Cellular Component: endoplasmic reticulum; lipid particle
Molecular Function: lipid binding
Biological Process: triacylglycerol catabolic process; lipid metabolic process
Reference #:  O60240 (UniProtKB)
Alt. Names/Synonyms: Lipid droplet-associated protein; PERI; perilipin 1; Perilipin-1; PLIN; PLIN1
Gene Symbols: PLIN1
Molecular weight: 55,990 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

perilipin

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 17 S81-p EPVVRRLsTQFTAAN
0 4 T82 PVVRRLsTQFTAANE
0 3 T85 RRLsTQFTAANELAC
0 1 S114 YPPEKIASELKDTIS
0 8 S126 TISTRLRSARNSISV
0 11 S130 RLRSARNSISVPIAS
0 2 S132 RSARNSISVPIASTS
0 1 S137 SISVPIASTSDKVLG
0 9 S174 TRAGRLASGGADLAL
0 1 P203 KEESAPAPGHQQAQK
2 6 G223 PSLLSRVGALTNTLS
0 4 A224 SLLSRVGALTNTLSR
2 0 S277 QAVSRRRSEVRVPWL
0 2 T299-p EEDHEDQtDtEGEDt
0 2 T301-p DHEDQtDtEGEDtEE
0 2 T306-p tDtEGEDtEEEEELE
0 1 K377 APAVSSTKGRAMsLs
0 7 S382-p STKGRAMsLsDALKG
0 2 S384-p KGRAMsLsDALKGVT
0 5 S408 YVPLPRLSLMEPESE
0 1 P423 FRDIDNPPAEVERRE
0 2 S436 REAERRASGAPSAGP
0 4 G442 ASGAPSAGPEPAPRL
0 1 P445 APSAGPEPAPRLAQP
0 1 A446 PSAGPEPAPRLAQPR
0 1 S455 RLAQPRRSLRSAQSP
0 2 Q460 RRSLRSAQSPGAPPG
0 3 G463 LRSAQSPGAPPGPGL
0 1 P466 AQSPGAPPGPGLEDE
0 1 V474 GPGLEDEVATPAAPR
6 2 S497-p EKPKRRVsDSFFRPS
0 1 S499 PKRRVsDSFFRPSVM
0 1 S504 sDSFFRPSVMEPILG
0 1 S516 ILGRTHYSQLRKKs_
6 1 S522-p YSQLRKKs_______
  mouse

 
S81-p EPVVRRLstQFtAAN
T82-p PVVRRLstQFtAANE
T85-p RRLstQFtAANELAC
S114-p YPPEKIAsELKGTIS
S126-p TISTRLRsARNsIsV
S130-p RLRsARNsIsVPIAs
S132-p RsARNsIsVPIAsTS
S137-p sIsVPIAsTSDKVLG
S174-p TRVGRLAsGGADLAL
S202-p DKESAPSsGRQRTQK
S222-p PSLVRRVstLANTLS
T223-p SLVRRVstLANTLSR
S276-p QVVSRRQsEVRVPWL
T298-p DESHDDQtDtEGEEt
T300-p SHDDQtDtEGEEtDD
T305-p tDtEGEEtDDEEEEE
K379-u AQAVSSTkGRAMsLs
S384-p STkGRAMsLsDALKG
S386-p kGRAMsLsDALKGVT
S410-p YVPLPRLsLMEPESE
S425-p FRDIDNPsAEAERKG
S433-p AEAERKGsGARPAsP
S439-p GsGARPAsPEstPRP
S442-p ARPAsPEstPRPGQP
T443-p RPAsPEstPRPGQPR
S452-p RPGQPRGsLRSVrGL
R457-m1 RGsLRSVrGLsAPsC
S460-p LRSVrGLsAPsCPGL
S463-p VrGLsAPsCPGLDDK
T471-p CPGLDDKtEASARPG
S492-p EKPARRVsDsFFRPs
S494-p PARRVsDsFFRPsVM
S499-p sDsFFRPsVMEPILG
S511-p ILGRAQYsQLRKKs_
S517-p YsQLRKKs_______
  rat

► Hide Isoforms
 
S81-p EPVVRRLsTQFTAAN
T82 PVVRRLsTQFTAANE
T85 RRLsTQFTAANELAC
S114 YPPEKIASELKGTIS
S126 TISTRLRSARNSISV
S130 RLRSARNSISVPIAS
S132 RSARNSISVPIASTS
S137 SISVPIASTSDKVLG
S174 TRVGRLASGGADLAL
S203 KVESAPSSGRQKTQK
S223-p PSLLRRVsTLANTLS
T224 SLLRRVsTLANTLSR
S277-p QVVSRRQsEVRVPWL
T299 DENHEDQTDTEGEET
T301 NHEDQTDTEGEETDE
T306 TDTEGEETDEEEEEE
K380 AQAVSSTKGRAMSLS
S385 STKGRAMSLSDALKG
S387 KGRAMSLSDALKGVT
S411 YVPLPRLSLMEPESE
P426 FQDIDNPPAEVERKG
S434 AEVERKGSGSRPASP
S440 GSGSRPASPESTARP
S443 SRPASPESTARPGQP
T444 RPASPESTARPGQPR
A452 ARPGQPRAACAVRGL
R457 PRAACAVRGLSAPSC
S460 ACAVRGLSAPSCPDL
S463 VRGLSAPSCPDLDDK
T471 CPDLDDKTETSARPG
S492 EKPARRVSDSFFRPS
S494 PARRVSDSFFRPSVM
S499 SDSFFRPSVMEPILG
S511 ILGRTQYSQLRKKS_
S517 YSQLRKKS_______
  perilipin iso2  
S81 EPVVRRLSTQFTAAN
T82 PVVRRLSTQFTAANE
T85 RRLSTQFTAANELAC
S114 YPPEKIASELKGTIS
S126 TISTRLRSARNSISV
S130 RLRSARNSISVPIAS
S132 RSARNSISVPIASTS
S137 SISVPIASTSDKVLG
S174 TRVGRLASGGADLAL
S203 KVESAPSSGRQKTQK
S223 PSLLRRVSTLANTLS
T224 SLLRRVSTLANTLSR
S277 QVVSRRQSEVRVPWL
T299 DENHEDQTDTEGEET
T301 NHEDQTDTEGEETDE
T306 TDTEGEETDEEEEEE
K380 AQAVSSTKGRAMSLS
S385 STKGRAMSLSDALKG
S387 KGRAMSLSDALKGVT
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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