Home

perilipin (human)

Overview perilipin an adipocyte protein of the peripilin family. A modulator of adipocyte lipid metabolism, coating lipid storage droplets to protect them from being broken down by hormone-sensitive lipase. A major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis. Note: This description may include information from UniProtKB. Protein type: Lipid binding protein Cellular Component: lipid particle Molecular Function: lipid binding Biological Process: triacylglycerol catabolic process; lipid metabolic process Reference #:  O60240 (UniProtKB) Alt. Names/Synonyms: Lipid droplet-associated protein; PERI; perilipin 1; Perilipin-1; PLIN; PLIN1 Gene Symbols: PLIN1 Molecular weight: 55,990 Da Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below perilipin

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T40-p	TCECFQKtYTSTKEA
0	1		S53-p	EAHPLVAsVCNAyEK
0	1		Y58-p	VAsVCNAyEKGVQSA
0	1		S72	ASSLAAWSMEPVVRR
2	17		S81-p	EPVVRRLsTQFTAAN
0	4		T82	PVVRRLsTQFTAANE
0	3		T85	RRLsTQFTAANELAC
0	1		S114	YPPEKIASELKDTIS
0	8		S126	TISTRLRSARNSISV
0	11		S130	RLRSARNSISVPIAS
0	2		S132	RSARNSISVPIASTS
0	1		S137	SISVPIASTSDKVLG
0	9		S174	TRAGRLASGGADLAL
0	1		S183	GADLALGSIEKVVEY
0	1		P203	KEESAPAPGHQQAQK
2	6		G223	PSLLSRVGALTNTLS
0	4		A224	SLLSRVGALTNTLSR
0	1		T228	RVGALTNTLSRYTVQ
2	0		S277	QAVSRRRSEVRVPWL
0	1		D294	LAAAQEEDHEDQtDt
0	2		T299-p	EEDHEDQtDtEGEDt
0	2		T301-p	DHEDQtDtEGEDtEE
0	2		T306-p	tDtEGEDtEEEEELE
0	1		T346	LQKTLQTTISAVTWA
0	1		K377	APAVSSTKGRAMsLs
0	6		S382-p	STKGRAMsLsDALKG
0	2		S384-p	KGRAMsLsDALKGVT
0	1		Y401-p	VVDTVVHyVPLPRLS
0	5		S408	yVPLPRLSLMEPESE
0	1		P423	FRDIDNPPAEVERRE
0	1		R429	PPAEVERREAERRAS
0	2		S436	REAERRASGAPSAGP
0	4		G442	ASGAPSAGPEPAPRL
0	1		P445	APSAGPEPAPRLAQP
0	1		A446	PSAGPEPAPRLAQPR
0	1		S455	RLAQPRRSLRSAQSP
0	2		Q460	RRSLRSAQSPGAPPG
0	3		G463	LRSAQSPGAPPGPGL
0	1		P466	AQSPGAPPGPGLEDE
0	1		V474	GPGLEDEVATPAAPR
5	2		S497-p	EKPKRRVsDSFFRPS
0	1		S499	PKRRVsDSFFRPSVM
0	1		S504	sDSFFRPSVMEPILG
0	1		Y515-p	PILGRTHySQLRKKs
0	1		S516	ILGRTHySQLRKKs_
5	1		S522-p	ySQLRKKs_______

	mouse
T40	TCECFQKTYNSTKEA
S53	EAHPLVASVCNAYEK
Y58	VASVCNAYEKGVQGA
S72-p	ASNLAAWsMEPVVRR
S81-p	EPVVRRLstQFtAAN
T82-p	PVVRRLstQFtAANE
T85-p	RRLstQFtAANELAC
S114-p	YPPEKIAsELKGTIS
S126-p	TISTRLRsARNsIsV
S130-p	RLRsARNsIsVPIAs
S132-p	RsARNsIsVPIAsTS
S137-p	sIsVPIAsTSDKVLG
S174-p	TRVGRLAsGGADLAL
S183-p	GADLALGsIEKVVEF
S202-p	DKESAPSsGRQRTQK
S222-p	PSLVRRVstLANtLS
T223-p	SLVRRVstLANtLSR
T227-p	RVstLANtLSRHTMQ
S276-p	QVVSRRQsEVRVPWL
S293-p	LAASQDEsHDDQtDt
T298-p	DEsHDDQtDtEGEEt
T300-p	sHDDQtDtEGEEtDD
T305-p	tDtEGEEtDDEEEEE
T348-p	VQNTLRNtISAVTWA
K379-u	AQAVSSTkGRAMsLs
S384-p	STkGRAMsLsDALKG
S386-p	kGRAMsLsDALKGVT
Y403	VVDTVVHYVPLPRLs
S410-p	YVPLPRLsLMEPESE
S425-p	FRDIDNPsAEAERkG
K431-a	PsAEAERkGsGARPA
S433-p	AEAERkGsGARPAsP
S439-p	GsGARPAsPEstPRP
S442-p	ARPAsPEstPRPGQP
T443-p	RPAsPEstPRPGQPR
S452-p	RPGQPRGsLRSVrGL
R457-m1	RGsLRSVrGLsAPsC
S460-p	LRSVrGLsAPsCPGL
S463-p	VrGLsAPsCPGLDDK
T471-p	CPGLDDKtEASARPG
S492-p	EKPARRVsDsFFRPs
S494-p	PARRVsDsFFRPsVM
S499-p	sDsFFRPsVMEPILG
Y510	PILGRAQYsQLRKKs
S511-p	ILGRAQYsQLRKKs_
S517-p	YsQLRKKs_______

	rat
T40	TCECFQKTYNSTKEA
S53	EAHPLVASVCNAYEK
Y58	VASVCNAYEKGVQGA
S72	ASNLAAWSMEPVVRR
S81-p	EPVVRRLsTQFTAAN
T82	PVVRRLsTQFTAANE
T85	RRLsTQFTAANELAC
S114	YPPEKIASELKGTIS
S126	TISTRLRSARNSISV
S130	RLRSARNSISVPIAS
S132	RSARNSISVPIASTS
S137	SISVPIASTSDKVLG
S174	TRVGRLASGGADLAL
S183	GADLALGSIEKVVEY
S203	KVESAPSSGRQKTQK
S223-p	PSLLRRVsTLANTLS
T224	SLLRRVsTLANTLSR
T228	RVsTLANTLSRHTMQ
S277-p	QVVSRRQsEVRVPWL
N294	LAASKDENHEDQTDT
T299	DENHEDQTDTEGEET
T301	NHEDQTDTEGEETDE
T306	TDTEGEETDEEEEEE
T349	VQKTLQNTISAVTWA
K380	AQAVSSTKGRAMSLS
S385	STKGRAMSLSDALKG
S387	KGRAMSLSDALKGVT
Y404	VVDTVVHYVPLPRLS
S411	YVPLPRLSLMEPESE
P426	FQDIDNPPAEVERKG
K432	PPAEVERKGSGSRPA
S434	AEVERKGSGSRPASP
S440	GSGSRPASPESTARP
S443	SRPASPESTARPGQP
T444	RPASPESTARPGQPR
A452	ARPGQPRAACAVRGL
R457	PRAACAVRGLSAPSC
S460	ACAVRGLSAPSCPDL
S463	VRGLSAPSCPDLDDK
T471	CPDLDDKTETSARPG
S492	EKPARRVSDSFFRPS
S494	PARRVSDSFFRPSVM
S499	SDSFFRPSVMEPILG
Y510	PILGRTQYSQLRKKS
S511	ILGRTQYSQLRKKS_
S517	YSQLRKKS_______

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.