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Protein Page:
GLT1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GLT1 an integral membrane protein belonging to the sodium:dicarboxylate (SDF) symporter family. Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by co-transporting sodium. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral
Cellular Component: membrane; plasma membrane; integral to membrane; axolemma
Molecular Function: protein binding; glutamate:sodium symporter activity; sodium:dicarboxylate symporter activity; L-glutamate transmembrane transporter activity
Biological Process: response to drug; multicellular organism growth; multicellular organismal aging; response to amino acid stimulus; visual behavior; synaptic transmission; positive regulation of glucose import; L-glutamate import; telencephalon development; adult behavior; response to wounding; cellular response to extracellular stimulus; ion transport; transmembrane transport
Reference #:  P43004 (UniProtKB)
Alt. Names/Synonyms: EAA2; EAAT2; Excitatory amino acid transporter 2; excitotoxic amino acid transporter 2; glial high affinity glutamate transporter; GLT-1; GLT1; Glutamate/aspartate transporter II; SLC1A2; Sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; Solute carrier family 1 member 2; solute carrier family 1, member 2
Gene Symbols: SLC1A2
Molecular weight: 62,104 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GLT1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 S3-p _____MAstEGANNM
0 2 T4-p ____MAstEGANNMP
1 1 K12 EGANNMPKQVEVRMH
0 7 S21-p VEVRMHDsHLGSEEP
0 5 G24 RMHDsHLGSEEPKHR
0 4 S25 MHDsHLGSEEPKHRH
1 16 K29 HLGSEEPKHRHLGLR
1 0 K40 LGLRLCDKLGKNLLL
1 0 K43 RLCDKLGKNLLLTLT
0 1 S100-p ILPLIISsLITGLSG
1 0 S113 SGLDAKASGRLGTRA
0 1 Y123-p LGTRAMVyyMSTTII
0 1 Y124-p GTRAMVyyMSTTIIA
0 1 K158 KQLGPGKKNDEVSSL
0 1 T371 SAGTLPVTFRCLEEN
0 1 K383 EENLGIDKRVTRFVL
0 1 K383 EENLGIDKRVTRFVL
1 0 Y404 NMDGTALYEAVAAIF
1 0 S480 LLDRMRTSVNVVGDS
1 0 S487 SVNVVGDSFGAGIVY
0 40 Y494 SFGAGIVYHLSKSEL
1 0 S497 AGIVYHLSKSELDTI
1 2 K498 GIVYHLSKSELDTID
1 0 S499 IVYHLSKSELDTIDS
1 3 S506 SELDTIDSQHRVHED
1 5 K518 HEDIEMTKTQSIyDD
0 1 T519 EDIEMTKTQSIyDDM
1 5 S521 IEMTKTQSIyDDMKN
0 16 Y523-p MTKTQSIyDDMKNHR
1 4 K527 QSIyDDMKNHRESNS
0 4 S532 DMKNHRESNSNQCVY
0 2 S534 KNHRESNSNQCVYAA
0 11 Y539 SNSNQCVYAAHNSVI
0 4 S544 CVYAAHNSVIVDECK
1 0 K551 SVIVDECKVTLAANG
1 1 K559 VTLAANGKSADCSVE
0 4 S560 TLAANGKSADCSVEE
0 6 S564 NGKSADCSVEEEPWk
1 9 K571 SVEEEPWKREK____
1 0 K571-sm SVEEEPWkREK____
  GLT1 iso3  
S3 _____MASTEGANNM
T4 ____MASTEGANNMP
K12 EGANNMPKQVEVRMH
S21 VEVRMHDSHLGSEEP
G24 RMHDSHLGSEEPKHR
S25 MHDSHLGSEEPKHRH
K29 HLGSEEPKHRHLGLR
K40 LGLRLCDKLGKNLLL
K43 RLCDKLGKNLLLTLT
S100 ILPLIISSLITGLSG
S113 SGLDAKASGRLGTRA
Y123 LGTRAMVYYMSTTII
Y124 GTRAMVYYMSTTIIA
K158 KQLGPGKKNDEVSSL
T371 SAGTLPVTFRCLEEN
K383 EENLGIDKRVTRFVL
K383 EENLGIDKRVTRFVL
Y404 NMDGTALYEAVAAIF
S480 LLDRMRTSVNVVGDS
S487 SVNVVGDSFGAGIVY
Y494 SFGAGIVYHLSKSEL
S497 AGIVYHLSKSELDTI
K498 GIVYHLSKSELDTID
S499 IVYHLSKSELDTIDS
S506 SELDTIDSQHRVHED
K518 HEDIEMTKTQSIYDD
T519 EDIEMTKTQSIYDDM
S521 IEMTKTQSIYDDMKN
Y523 MTKTQSIYDDMKNHR
K527 QSIYDDMKNHRESNS
S532 DMKNHRESNSNQCVY
S534 KNHRESNSNQCVYAA
Y539 SNSNQCVYAAHNSVI
S544 CVYAAHNSVIVDECK
K551 SVIVDECKVHFPFMD
- gap
- gap
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
S3-p _____MAstEGANNM
T4-p ____MAstEGANNMP
K12-ub EGANNMPkQVEVRMH
S21-p VEVRMHDsHLssDEP
S24-p RMHDsHLssDEPkHR
S25-p MHDsHLssDEPkHRN
K29-ub HLssDEPkHRNLGMR
K40 LGMRMCDKLGKNLLL
K43 RMCDKLGKNLLLSLT
S100 ILPLIISSLITGLSG
S113 SGLDAKASGRLGTRA
Y123 LGTRAMVYYMSTTII
Y124 GTRAMVYYMSTTIIA
K158-ub KQLGPGKkNDEVSSL
T370-p SAGTLPVtFRCLEDN
K382 EDNLGIDKRVTRFVL
K382-ub EDNLGIDkRVTRFVL
Y403 NMDGTALYEAVAAIF
S479 LLDRMRTSVNVVGDS
S486 SVNVVGDSFGAGIVy
Y493-p SFGAGIVyHLSkSEL
S496 AGIVyHLSkSELDTI
K497-ub GIVyHLSkSELDTID
S498 IVyHLSkSELDTIDs
S505-p SELDTIDsQHRMQED
K517-ub QEDIEMTktQsIyDD
T518-p EDIEMTktQsIyDDk
S520-p IEMTktQsIyDDkNH
Y522-p MTktQsIyDDkNHRE
K525-ub tQsIyDDkNHREsNs
S530-p DDkNHREsNsNQCVy
S532-p kNHREsNsNQCVyAA
Y537-p sNsNQCVyAAHNsVV
S542-p CVyAAHNsVVIDECK
K549 sVVIDECKVTLAANG
K557-ub VTLAANGksADCsVE
S558-p TLAANGksADCsVEE
S562-p NGksADCsVEEEPWk
K569-ub sVEEEPWkREK____
K569 sVEEEPWKREK____
  GLT1 iso2  
S3 _____MVSANNMPkQ
- gap
K9-ub VSANNMPkQVEVRMH
S18 VEVRMHDSHLSSDEP
S21 RMHDSHLSSDEPKHR
S22 MHDSHLSSDEPKHRN
K26 HLSSDEPKHRNLGMR
K37 LGMRMCDKLGKNLLL
K40 RMCDKLGKNLLLSLT
S97 ILPLIISSLITGLSG
S110 SGLDAKASGRLGTRA
Y120 LGTRAMVYYMSTTII
Y121 GTRAMVYYMSTTIIA
K155 KQLGPGKKNDEVSSL
T367 SAGTLPVTFRCLEDN
K379 EDNLGIDKRVTRFVL
K379 EDNLGIDKRVTRFVL
Y400 NMDGTALYEAVAAIF
S476 LLDRMRTSVNVVGDS
S483 SVNVVGDSFGAGIVY
Y490 SFGAGIVYHLSKSEL
S493 AGIVYHLSKSELDTI
K494 GIVYHLSKSELDTID
S495 IVYHLSKSELDTIDS
S502 SELDTIDSQHRMQED
K514 QEDIEMTKTQSIYDD
T515 EDIEMTKTQSIYDDK
S517 IEMTKTQSIYDDKNH
Y519 MTKTQSIYDDKNHRE
K522 TQSIYDDKNHRESNS
S527 DDKNHRESNSNQCVY
S529 KNHRESNSNQCVYAA
Y534 SNSNQCVYAAHNSVV
S539 CVYAAHNSVVIDECK
K546 SVVIDECKVTLAANG
K554 VTLAANGKSADCSVE
S555 TLAANGKSADCSVEE
S559 NGKSADCSVEEEPWK
K566 SVEEEPWKREK____
K566 SVEEEPWKREK____
  rat

► Hide Isoforms
 
S3-p _____MAsTEGANNM
T4 ____MAsTEGANNMP
K12-ub EGANNMPkQVEVRMH
S21-p VEVRMHDsHLssEEP
S24-p RMHDsHLssEEPkHR
S25-p MHDsHLssEEPkHRN
K29-ub HLssEEPkHRNLGMR
K40-ub LGMRMCDkLGkNLLL
K43-ub RMCDkLGkNLLLSLT
S100 ILPLIISSLITGLSG
S113-p SGLDAKAsGRLGTRA
Y123 LGTRAMVYYMSTTII
Y124 GTRAMVYYMSTTIIA
K158 KQLGPGKKNDEVSSL
T370 SAGTLPVTFRCLEDN
K382-ac EDNLGIDkRVTRFVL
K382 EDNLGIDKRVTRFVL
Y403-p NMDGTALyEAVAAIF
S479-p LLDRMRTsVNVVGDs
S486-p sVNVVGDsFGAGIVy
Y493-p sFGAGIVyHLsksEL
S496-p AGIVyHLsksELDTI
K497-ub GIVyHLsksELDTID
S498-p IVyHLsksELDTIDs
S505-p sELDTIDsQHRMHED
K517-ub HEDIEMTkTQsVyDD
T518 EDIEMTkTQsVyDDT
S520-p IEMTkTQsVyDDTkN
Y522-p MTkTQsVyDDTkNHR
K526-ub QsVyDDTkNHRESNS
S531 DTkNHRESNSNQCVy
S533 kNHRESNSNQCVyAA
Y538-p SNSNQCVyAAHNSVV
S543 CVyAAHNSVVIDECk
K550-ub SVVIDECkVTLAANG
K558-ub VTLAANGkSADCSVE
S559 TLAANGkSADCSVEE
S563 NGkSADCSVEEEPWk
K570-ub SVEEEPWkREK____
K570 SVEEEPWKREK____
  GLT1 iso3  
S3 _____MASTEGANNM
T4 ____MASTEGANNMP
K12 EGANNMPKQVEVRMH
S21 VEVRMHDSHLSSEEP
S24 RMHDSHLSSEEPKHR
S25 MHDSHLSSEEPKHRN
K29 HLSSEEPKHRNLGMR
K40 LGMRMCDKLGKNLLL
K43 RMCDKLGKNLLLSLT
S100 ILPLIISSLITGLSG
S113 SGLDAKASGRLGTRA
Y123 LGTRAMVYYMSTTII
Y124 GTRAMVYYMSTTIIA
K158 KQLGPGKKNDEVSSL
T370 SAGTLPVTFRCLEDN
K382 EDNLGIDKRVTRFVL
K382 EDNLGIDKRVTRFVL
Y403 NMDGTALYEAVAAIF
S479 LLDRMRTSVNVVGDS
S486 SVNVVGDSFGAGIVY
Y493 SFGAGIVYHLSKSEL
S496 AGIVYHLSKSELDTI
K497 GIVYHLSKSELDTID
S498 IVYHLSKSELDTIDS
S505 SELDTIDSQHRMHED
K517 HEDIEMTKTQsIyDD
T518 EDIEMTKTQsIyDDT
S520-p IEMTKTQsIyDDTKN
Y522-p MTKTQsIyDDTKNHR
K526 QsIyDDTKNHRESNS
S531 DTKNHRESNSNQCVN
S533 KNHRESNSNQCVNAA
N538 SNSNQCVNAAHNSVV
S543 CVNAAHNSVVIDECK
K550 SVVIDECKVPFPFLD
- gap
- gap
- gap
- gap
- gap
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