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Protein Page:
eIF2B-beta (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
eIF2B-beta eukaryotic translation initiation factor 2B, subunit 5. A translational regulatory protein that functions in the early steps of protein synthesis by catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutation in EIF2B5 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy. Note: This description may include information from UniProtKB.
Protein type: Translation; RNA binding protein; GEFs, misc.; GEFs; Cell development/differentiation
Cellular Component: eukaryotic translation initiation factor 2B complex; cytoplasm; cytosol
Molecular Function: protein binding; GTP binding; translation initiation factor activity; guanyl-nucleotide exchange factor activity; S-methyl-5-thioribose-1-phosphate isomerase activity; ATP binding
Biological Process: myelination; response to peptide hormone stimulus; central nervous system development; translation; cellular response to stimulus; cellular protein metabolic process; ovarian follicle development; methionine salvage; response to heat; translational initiation; response to glucose stimulus; gene expression; oligodendrocyte development; regulation of translational initiation; positive regulation of GTPase activity
Reference #:  P49770 (UniProtKB)
Alt. Names/Synonyms: EI2BB; eIF-2B GDP-GTP exchange factor subunit beta; EIF-2Bbeta; EIF2B; EIF2B2; EIF2BB; eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa; S20I15; S20III15; Translation initiation factor eIF-2B subunit beta
Gene Symbols: EIF2B2
Molecular weight: 38,990 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
Select Structure to View Below

eIF2B-beta

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T47-p GLLRQIItDHRWSNA
0 1 S100-p YGRLHGRsDEsDQQE
0 1 S103-p LHGRsDEsDQQESLH
0 1 T236-p VNKVIIGtktILANG
0 2 K237-ub NKVIIGtktILANGA
0 1 T238-p KVIIGtktILANGAL
  mouse

 
T47-p GLLRRLItDHHWNNA
S100 YGRLHGRSDESDQQE
S103 LHGRSDESDQQESLH
T236 VNKVIIGTkTILANG
K237-ub NKVIIGTkTILANGS
T238 KVIIGTkTILANGSL
  rat

 
T47 GLLRRLITDHHWNNA
S100 YGRLHGRSDESDQQE
S103 LHGRSDESDQQESLH
T236 VNKVIIGTKTILANG
K237 NKVIIGTKTILANGS
T238 KVIIGTKTILANGSL
  rabbit

 
T47 GLLRRIITDHRWSNA
S100 YGRLHGRSDESDQQE
S103 LHGRSDESDQQESLH
T236 VNKVIIGTKTILANG
K237 NKVIIGTKTILANGA
T238 KVIIGTKTILANGAL
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