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Protein Page:
LRRK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LRRK1 a large multidomain protein kinase with a TKL-type kinase domain, multiple protein-protein interaction domains and a mitochondrial Rho domain (MIRO). Involved in the trafficking of epidermal growth factor (EGFR) from early to late endosomes. Forms a complex with activated EGFR via the adaptor protein Grb2. Subsequently, LRRK1 and EGFR are internalized and co-localized in early endosomes. LRRK1 is phosphorylated by EGFR, inhibiting its kinase activity. The reduction of kinase activity plays an important role in endosomal trafficking of the EGFR. Serves as a scaffold expediting the interaction of EGFR with the endosomal sorting complex required for efficient sorting of EGFR to the inner vesicles of multivesicular bodies. Plays a critical role in negative regulation of bone mass in part through modulating the c-Src signaling pathway in mice. Phosphorylation of c-Src at Tyr-527 is significantly elevated whereas at Tyr-416 is decreased in LRRK1 KO mouse osteoclasts. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; LRRK family
Cellular Component: mitochondrion; cytoplasm
Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; GTP binding; metal ion binding; ATP binding
Biological Process: small GTPase mediated signal transduction; protein amino acid phosphorylation
Reference #:  Q38SD2 (UniProtKB)
Alt. Names/Synonyms: FLJ23119; FLJ27465; KIAA1790; leucine-rich repeat kinase 1; Leucine-rich repeat serine/threonine-protein kinase 1; LRRK1; RIPK6; Roco1
Gene Symbols: LRRK1
Molecular weight: 225,393 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Select Structure to View Below

LRRK1

Protein Structure Not Found.


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Sites Implicated In
endocytosis, altered: Y971‑p
enzymatic activity, inhibited: Y971‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T30-p CPERAMEtLNGAGDT
0 1 T175-p VVKLLVLtHGADPEs
0 1 S182-p tHGADPEsyAVRKNE
0 1 Y183-p HGADPEsyAVRKNEF
0 1 S337-p RLLEIDIsSNKLSHL
0 13 T358-p LSKLQKLtAsKNCLE
0 12 S360-p KLQKLtAsKNCLEKL
0 1 T823 RQLIFHVTCSMKDVG
1 0 Y971-p TQQTEEQyFQFLAKF
0 1 S1038 FIARMLISLAEMDLQ
0 1 K1054 FENKKNTKSRNRKVT
1 6 Y1063-p RNRKVTIysFTGNQR
0 1 S1064-p NRKVTIysFTGNQRN
0 1 Y1098-p LVTFDGGyLsVEssD
0 1 S1100-p TFDGGyLsVEssDVN
0 1 S1103-p GGyLsVEssDVNWKK
0 1 S1104-p GyLsVEssDVNWKKK
0 1 S1241-p ENSKLEHsEDEGsVL
0 1 S1246-p EHsEDEGsVLGQGGS
0 6 Y1258 GGSGTVIYRARYQGQ
0 1 K1276-ac VKRFHIKkFkNFANV
0 1 K1278-ac RFHIKkFkNFANVPA
1 8 Y1430-p GVEGTPGyQAPEIRP
0 1 T1628-p LDTPAVVtCFLAVPV
0 1 S1855-p PPRQAARsPSsLPSS
0 1 S1858-p QAARsPSsLPSSPAS
  mouse

 
T30 CPGPAMETHNGAEDM
T175 VVKLLVLTHGADPEN
N182 THGADPENYAVRKNE
Y183 HGADPENYAVRKNEF
S337 RLLEIDISSNKLSHL
T358 LSKLQKLTASKNYLE
S360 KLQKLTASKNYLERL
T823-p RQLIFHVtCNMKDVG
Y971 TQQTEEQYFQFLAKF
S1038-p FIARMLIsLAEMDLQ
K1054-m1 FENKKNTkSRNRKVT
Y1063-p RNRKVTIySFTGSQR
S1064 NRKVTIySFTGSQRN
Y1098 LVTFDGGYLSVESSD
S1100 TFDGGYLSVESSDVN
S1103 GGYLSVESSDVNWKK
S1104 GYLSVESSDVNWKKK
T1241 ENSKLEHTEGENSIL
S1246 EHTEGENSILGQGGS
Y1258-p GGSGTVIyQARYQGQ
K1276 VKRFHIKKFKNSANA
K1278 RFHIKKFKNSANAPA
Y1430-p GVEGTPGyQAPEIRP
T1628 LDTPAVVTCFLAVPV
S1854 PPHQDPRSPSSLPSS
S1857 QDPRSPSSLPSSLTS
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