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Protein Page:
LRRK1 (human)

Overview
LRRK1 a large multidomain protein kinase with a TKL-type kinase domain, multiple protein-protein interaction domains and a mitochondrial Rho domain (MIRO). Involved in the trafficking of epidermal growth factor (EGFR) from early to late endosomes. Forms a complex with activated EGFR via the adaptor protein Grb2. Subsequently, LRRK1 and EGFR are internalized and co-localized in early endosomes. LRRK1 is phosphorylated by EGFR, inhibiting its kinase activity. The reduction of kinase activity plays an important role in endosomal trafficking of the EGFR. Serves as a scaffold expediting the interaction of EGFR with the endosomal sorting complex required for efficient sorting of EGFR to the inner vesicles of multivesicular bodies. Plays a critical role in negative regulation of bone mass in part through modulating the c-Src signaling pathway in mice. Phosphorylation of c-Src at Tyr-527 is significantly elevated whereas at Tyr-416 is decreased in LRRK1 KO mouse osteoclasts. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; EC 2.7.11.1; TKL group; LRRK family
Cellular Component: mitochondrion; cytoplasm
Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; GTP binding; metal ion binding; ATP binding
Biological Process: small GTPase mediated signal transduction
Reference #:  Q38SD2 (UniProtKB)
Alt. Names/Synonyms: FLJ23119; FLJ27465; KIAA1790; leucine-rich repeat kinase 1; Leucine-rich repeat serine/threonine-protein kinase 1; LRRK1; RIPK6; Roco1
Gene Symbols: LRRK1
Molecular weight: 225,393 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Select Structure to View Below

LRRK1

Protein Structure Not Found.


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Sites Implicated In
endocytosis, altered: Y971‑p
enzymatic activity, inhibited: Y971‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T30-p CPERAMEtLNGAGDT
0 13 T358-p LSKLQKLtAsKNCLE
0 12 S360-p KLQKLtAsKNCLEKL
1 0 Y971-p TQQTEEQyFQFLAKF
0 6 Y1063-p RNRKVTIySFTGNQR
0 6 Y1258 GGSGTVIYRARYQGQ
0 8 Y1430-p GVEGTPGyQAPEIRP
  mouse

 
T30 CPGPAMETHNGAEDM
T358 LSKLQKLTASKNYLE
S360 KLQKLTASKNYLERL
Y971 TQQTEEQYFQFLAKF
Y1063-p RNRKVTIySFTGSQR
Y1258-p GGSGTVIyQARYQGQ
Y1430-p GVEGTPGyQAPEIRP
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