Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CHKB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CHKB Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis. Belongs to the choline/ethanolamine kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - glycerophospholipid; EC 2.7.1.32; Kinase, other; EC 2.7.1.82
Cellular Component: cytosol
Molecular Function: ethanolamine kinase activity; choline kinase activity; ATP binding
Biological Process: CDP-choline pathway; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidylethanolamine biosynthetic process; phosphatidylcholine biosynthetic process; phosphorylation
Reference #:  Q9Y259 (UniProtKB)
Alt. Names/Synonyms: CHETK; CHKB; CHKL; Choline kinase beta; Choline kinase-like protein; Choline/ethanolamine kinase; choline/ethanolamine kinase beta; CK; CKB; CKEKB; EK; EKB; Ethanolamine kinase; Ethanolamine kinase beta
Gene Symbols: CHKB
Molecular weight: 45,271 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Select Structure to View Below

CHKB

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 S39-p TPKRRRAssLSRDAE
0 6 S40-p PKRRRAssLSRDAER
0 1 Y72-p QPEELRVyPVsGGLs
0 1 S75-p ELRVyPVsGGLsNLL
0 1 S79-p yPVsGGLsNLLFRCS
0 1 K321-ub RHYLAEAkKGETLSQ
0 1 Y381-p AQSRFQFyFQQKGQL
0 1 S394-p QLTSVHSsS______
  mouse

 
S39-p IPNRRRAsSLSRDAQ
S40 PNRRRAsSLSRDAQR
C72 RPEELSVCPVSGGLS
S75 ELSVCPVSGGLSNLL
S79 CPVSGGLSNLLFRCS
Q321 RHYLAEVQKGEILSE
Y381 AQSRFQFYFQQKGQL
S393 GQLTSSPSS______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.