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Protein Page:
CHKB (human)

Overview
CHKB Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis. Belongs to the choline/ethanolamine kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Kinase, other; Lipid Metabolism - glycerophospholipid; EC 2.7.1.32; EC 2.7.1.82
Cellular Component: cytosol
Molecular Function: ethanolamine kinase activity; choline kinase activity; ATP binding
Biological Process: CDP-choline pathway; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidylethanolamine biosynthetic process; phosphatidylcholine biosynthetic process
Reference #:  Q9Y259 (UniProtKB)
Alt. Names/Synonyms: CHETK; CHKB; CHKL; Choline kinase beta; Choline kinase-like protein; Choline/ethanolamine kinase; choline/ethanolamine kinase beta; CK; CKB; CKEKB; EK; EKB; Ethanolamine kinase; Ethanolamine kinase beta
Gene Symbols: CHKB
Molecular weight: 45,271 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Select Structure to View Below

CHKB

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S39-p TPKRRRAssLSRDAE
0 5 S40-p PKRRRAssLSRDAER
0 1 Y381-p AQSRFQFyFQQKGQL
0 1 S394-p QLTSVHSsS______
  mouse

 
S39-p IPNRRRAsSLSRDAQ
S40 PNRRRAsSLSRDAQR
Y381 AQSRFQFYFQQKGQL
S393 GQLTSSPSS______
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