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CHKB (human)

Overview CHKB Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis. Belongs to the choline/ethanolamine kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Lipid Metabolism - glycerophospholipid; EC 2.7.1.82; EC 2.7.1.32; Kinase, other Cellular Component: cytoplasm; cytosol Molecular Function: choline kinase activity; ethanolamine kinase activity; ATP binding Biological Process: CDP-choline pathway; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidylethanolamine biosynthetic process; phosphatidylcholine biosynthetic process Reference #:  Q9Y259 (UniProtKB) Alt. Names/Synonyms: CHETK; CHKB; CHKL; Choline kinase beta; Choline kinase-like protein; Choline/ethanolamine kinase; choline/ethanolamine kinase beta; CK; CKB; CKEKB; EK; EKB; Ethanolamine kinase; Ethanolamine kinase beta Gene Symbols: CHKB Molecular weight: 45,271 Da Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states

Select Structure to View Below CHKB 2IG7 - A/B=11-394 (human) 3FEG - A=35-395 (human) 3LQ3 - A=14-395 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 2IG7 3FEG 3LQ3  |  ENZYME 2.7.1.32 2.7.1.82  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		S39-p	TPKRRRAssLSRDAE
0	5		S40-p	PKRRRAssLSRDAER
0	1		Y72-p	QPEELRVyPVsGGLs
0	1		S75-p	ELRVyPVsGGLsNLL
0	1		S79-p	yPVsGGLsNLLFRCS
0	1		K321-u	RHYLAEAkKGETLSQ

	mouse
S39	IPNRRRASSLSRDAQ
S40	PNRRRASSLSRDAQR
C72	RPEELSVCPVSGGLS
S75	ELSVCPVSGGLSNLL
S79	CPVSGGLSNLLFRCS
Q321	RHYLAEVQKGEILSE

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