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Protein Page:
Cdc37 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Cdc37 a molecular chaperone that functions in cell signal transduction. Forms complexes with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. Also interacts with androgen receptor. It is thought to play a critical role in directing Hsp90 to its target kinases. Note: This description may include information from UniProtKB.
Protein type: Chaperone
Cellular Component: protein complex; cytoplasm; cytosol
Molecular Function: protein kinase B binding; protein binding; heat shock protein binding; chaperone binding; unfolded protein binding; Hsp90 protein binding; mitogen-activated protein kinase kinase kinase binding
Biological Process: regulation of cyclin-dependent protein kinase activity; protein targeting
Reference #:  Q16543 (UniProtKB)
Alt. Names/Synonyms: CDC37; CDC37 (cell division cycle 37, S. cerevisiae, homolog); CDC37 cell division cycle 37 homolog; CDC37A; cell division cycle 37 homolog (S. cerevisiae); cell division cycle 37 protein; Hsp90 chaperone protein kinase-targeting subunit; Hsp90 co-chaperone Cdc37; p50Cdc37
Gene Symbols: CDC37
Molecular weight: 44,468 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
CST Pathways:  Inhibition of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Cdc37

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S13‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S5-p ___MVDYsVWDHIEV
5 7 S13-p VWDHIEVsDDEDETH
0 1 K45-a ERMEQFQkEKEELDR
0 5 K69-u AECQRKLkELEVAEG
0 14 K78-a LEVAEGGkAELERLQ
0 1 K101-u EERSWEQkLEEMRKK
0 2 K110-u EEMRKKEkSMPWNVD
0 2 T118-p SMPWNVDtLskDGFS
0 2 S120-p PWNVDtLskDGFSKS
0 1 K121-u WNVDtLskDGFSKSM
0 1 K135-u MVNTKPEkTEEDSEE
0 2 K154-a KHKTFVEkYEKQIKH
0 1 K240-a CFRQFFTkIKTADRQ
0 1 K260-u NDELEAFkERVRGRA
0 81 Y278-p IEKAMKEyEEEERKK
0 172 Y298-p GLDPVEVyEsLPEEL
0 6 S300-p DPVEVyEsLPEELQk
0 8 K307-u sLPEELQkCFDVKDV
0 1 S322-p QMLQDAIskMDPTDA
0 1 K323-u MLQDAIskMDPTDAk
0 1 K330-a kMDPTDAkYHMQRCI
0 2 K330-u kMDPTDAkYHMQRCI
0 22 K347-u GLWVPNSkASEAkEG
0 5 K352-u NSkASEAkEGEEAGP
0 2 T370-p LLEAVPKtGDEkDVs
0 1 K374-u VPKtGDEkDVsV___
0 3 S377-p tGDEkDVsV______
8733 : Phospho-CDC37 (Ser13) Antibody
13248 : Phospho-CDC37 (Ser13) (D8P8F) Rabbit mAb
  mouse

 
S5 ___MVDYSVWDHIEV
S13-p VWDHIEVsDDEDETH
K45 ERMEQFQKEKEELDR
K69-u AECQRKLkELEVAES
Q79 EVAESDGQVELERLR
K102 EERSWEQKLEDMRKK
K111 EDMRKKEKNMPWNVD
T119-p NMPWNVDtLsKDGFS
S121-p PWNVDtLsKDGFSKS
K122 WNVDtLsKDGFSKSM
K136 MVNTKPEKAEEDSEE
K155 KHKTFVEKYEKQIKH
K241 CFRQFFTKIKTADHQ
K261 KYELEAFKERVRGRA
Y279-p IEKAMKEyEEEERKK
Y299-p GLDPVEVyEsLPEEL
S301-p DPVEVyEsLPEELQk
K308-u sLPEELQkCFDVKDV
S323 QMLQDAISKMDPTDA
K324 MLQDAISKMDPTDAk
K331 KMDPTDAKYHMQRCI
K331-u KMDPTDAkYHMQRCI
K348-u GLWVPNSkSGEAkEG
K353-u NSkSGEAkEGEEAGP
A371 LLEAVPKAGNEKDVS
K375 VPKAGNEKDVSA___
S378 AGNEKDVSA______
8733 : Phospho-CDC37 (Ser13) Antibody
13248 : Phospho-CDC37 (Ser13) (D8P8F) Rabbit mAb
  rat

 
S5 ___MVDYSVWDHIEV
S13-p VWDHIEVsDDEDETH
K45 ERMEQFQKEKEELDR
K69 AECQRKLKELEVAEG
Q79 EVAEGGGQVELERLR
K102 EERSWEQKLEDMRKK
K111 EDMRKKEKNMPWNVD
T119 NMPWNVDTLSKDGFS
S121 PWNVDTLSKDGFSKS
K122 WNVDTLSKDGFSKSM
K136 MVNTKPEKAEEDSEE
K155 KHKTFVEKYEKQIKH
K241 CFRQFFTKIKTADQQ
K261 KYELEAFKERVRGRA
Y279 IEKAMKEYEEEERKK
Y299 GLDPVEVYESLPEEL
S301 DPVEVYESLPEELQK
K308 SLPEELQKCFDVKDV
S323 QMLQDAISKMDPTDA
K324 MLQDAISKMDPTDAK
K331 KMDPTDAKYHMQRCI
K331 KMDPTDAKYHMQRCI
K348 GLWVPNSKSGEAKEG
K353 NSKSGEAKEGEEAGP
A371 LLEAVPKAGNEKDIS
K375 VPKAGNEKDISA___
S378 AGNEKDISA______
8733 : Phospho-CDC37 (Ser13) Antibody
13248 : Phospho-CDC37 (Ser13) (D8P8F) Rabbit mAb
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