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Cdc37 (human)

Overview Cdc37 a molecular chaperone that functions in cell signal transduction. Forms complexes with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. Also interacts with androgen receptor. It is thought to play a critical role in directing Hsp90 to its target kinases. Note: This description may include information from UniProtKB. Protein type: Chaperone Cellular Component: cytoplasm; cytosol Molecular Function: protein binding; heat shock protein binding; unfolded protein binding; Hsp90 protein binding; protein kinase binding Biological Process: regulation of cyclin-dependent protein kinase activity; protein targeting Reference #:  Q16543 (UniProtKB) Alt. Names/Synonyms: CDC37; CDC37 (cell division cycle 37, S. cerevisiae, homolog); CDC37 cell division cycle 37 homolog; CDC37A; cell division cycle 37 homolog (S. cerevisiae); cell division cycle 37 protein; Hsp90 chaperone protein kinase-targeting subunit; Hsp90 co-chaperone Cdc37; p50Cdc37 Gene Symbols: CDC37 Molecular weight: 44,468 Da Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states CST Pathways:  Inhibition of Apoptosis Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Cdc37 1US7 - B=127-378 (human) 2K5B - B=148-276 (human) 2W0G - A=148-276 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1US7 2K5B 2W0G  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: S13‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
5	6		S13-p	VWDHIEVsDDEDETH
0	1		K45-a	ERMEQFQkEKEELDR
0	1		K67-u	KVAECQRkLkELEVA
0	5		K69-u	AECQRkLkELEVAEG
0	14		K78-a	LEVAEGGkAELERLQ
0	1		K101-u	EERSWEQkLEEMRKK
0	2		K110-u	EEMRKKEkSMPWNVD
0	1		T118-p	SMPWNVDtLskDGFS
0	1		S120-p	PWNVDtLskDGFSKS
0	1		K121-u	WNVDtLskDGFSKSM
0	1		K132	SKSMVNTKPEkTEED
0	1		K135-u	MVNTKPEkTEEDSEE
0	2		K154-a	KHKTFVEkYEKQIKH
0	1		K240-a	CFRQFFTkIKTADRQ
0	1		K260-u	NDELEAFkERVRGRA
0	81		Y278-p	IEKAMKEyEEEERKK
0	172		Y298-p	GLDPVEVyEsLPEEL
0	6		S300-p	DPVEVyEsLPEELQk
0	8		K307-u	sLPEELQkCFDVKDV
0	1		K323-u	MLQDAISkMDPTDAk
0	1		K330-a	kMDPTDAkYHMQRCI
0	2		K330-u	kMDPTDAkYHMQRCI
0	22		K347-u	GLWVPNSkASEAkEG
0	5		K352-u	NSkASEAkEGEEAGP
0	1		T370-p	LLEAVPKtGDEkDVs
0	1		K374-u	VPKtGDEkDVsV___
0	3		S377-p	tGDEkDVsV______

	mouse
S13-p	VWDHIEVsDDEDETH
K45	ERMEQFQKEKEELDR
K67	KVAECQRKLkELEVA
K69-u	AECQRKLkELEVAES
Q79	EVAESDGQVELERLR
K102	EERSWEQKLEDMRKK
K111	EDMRKKEKNMPWNVD
T119-p	NMPWNVDtLsKDGFS
S121-p	PWNVDtLsKDGFSKS
K122	WNVDtLsKDGFSKSM
K133-u	SKSMVNTkPEKAEED
K136	MVNTkPEKAEEDSEE
K155	KHKTFVEKYEKQIKH
K241	CFRQFFTKIKTADHQ
K261	KYELEAFKERVRGRA
Y279-p	IEKAMKEyEEEERKK
Y299-p	GLDPVEVyESLPEEL
S301	DPVEVyESLPEELQk
K308-u	SLPEELQkCFDVKDV
K324	MLQDAISKMDPTDAk
K331	KMDPTDAKYHMQRCI
K331-u	KMDPTDAkYHMQRCI
K348-u	GLWVPNSkSGEAkEG
K353-u	NSkSGEAkEGEEAGP
A371	LLEAVPKAGNEKDVS
K375	VPKAGNEKDVSA___
S378	AGNEKDVSA______

	rat
S13-p	VWDHIEVsDDEDETH
K45	ERMEQFQKEKEELDR
K67	KVAECQRKLKELEVA
K69	AECQRKLKELEVAEG
Q79	EVAEGGGQVELERLR
K102	EERSWEQKLEDMRKK
K111	EDMRKKEKNMPWNVD
T119	NMPWNVDTLSKDGFS
S121	PWNVDTLSKDGFSKS
K122	WNVDTLSKDGFSKSM
K133	SKSMVNTKPEKAEED
K136	MVNTKPEKAEEDSEE
K155	KHKTFVEKYEKQIKH
K241	CFRQFFTKIKTADQQ
K261	KYELEAFKERVRGRA
Y279	IEKAMKEYEEEERKK
Y299	GLDPVEVYESLPEEL
S301	DPVEVYESLPEELQK
K308	SLPEELQKCFDVKDV
K324	MLQDAISKMDPTDAK
K331	KMDPTDAKYHMQRCI
K331	KMDPTDAKYHMQRCI
K348	GLWVPNSKSGEAKEG
K353	NSKSGEAKEGEEAGP
A371	LLEAVPKAGNEKDIS
K375	VPKAGNEKDISA___
S378	AGNEKDISA______

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