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Protein Page:
SLC22A5 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SLC22A5 Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. Defects in SLC22A5 are the cause of systemic primary carnitine deficiency (CDSP). CDSP is an autosomal recessive disorder of fatty acid oxidation caused by defective carnitine transport. Present early in life with hypoketotic hypoglycemia and acute metabolic decompensation, or later in life with skeletal myopathy or cardiomyopathy. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter
Cellular Component: brush border membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane; integral to membrane
Molecular Function: protein binding; antibiotic transporter activity; symporter activity; carnitine transporter activity; drug transporter activity; quaternary ammonium group transmembrane transporter activity; ATP binding; PDZ domain binding
Biological Process: quaternary ammonium group transport; drug transport; sodium ion transport; multidrug transport; transmembrane transport; carnitine transport; quorum sensing during interaction with host
Reference #:  O76082 (UniProtKB)
Alt. Names/Synonyms: CDSP; FLJ46769; high-affinity sodium dependent carnitine cotransporter; High-affinity sodium-dependent carnitine cotransporter; OCTN2; OCTN2VT; organic cation transporter 2; organic cation transporter 5; Organic cation/carnitine transporter 2; S22A5; SLC22A5; solute carrier family 22 (organic cation transporter), member 5; solute carrier family 22 (organic cation/carnitine transporter), member 5; Solute carrier family 22 member 5
Gene Symbols: SLC22A5
Molecular weight: 62,752 Da
Basal Isoelectric point: 8.07  Predict pI for various phosphorylation states
Select Structure to View Below

SLC22A5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K324-u ELQDLSSkKQQSHNI
0 1 Y486-p YFVYLGAyDRFLPYI
0 1 K531 MLRVKGMKHRKTPSH
0 1 K543 PSHTRMLKDGQERPt
0 4 R548 MLKDGQERPtILkST
0 2 T550-p KDGQERPtILkSTAF
0 2 K553-u QERPtILkSTAF___
  mouse

 
T324 ELQDLNSTKPQLHHI
Y486 YFVYLGAYDRFLPYI
K531-u MLRVKGIkQWQIQSQ
K543-u QSQTRMQkDGEEsPt
S548-p MQkDGEEsPtVLKST
T550-p kDGEEsPtVLKSTAF
K553 EEsPtVLKSTAF___
  rat

 
K324 ELQDLNSKKPQSHHI
Y486 YFVYLGAYDRFLPYI
K531 MLRVKGIKQWQIQSQ
K543 QSQTRTQKDGGEsPT
S548-p TQKDGGEsPTVLKST
T550 KDGGEsPTVLKSTAF
K553 GEsPTVLKSTAF___
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