Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. 2 human isoforms produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); EC 184.108.40.206; Kinase, protein; CK1 group; VRK family
Chromosomal Location of Human Ortholog: 19q13
Cellular Component: cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; ATP binding
Biological Process: positive regulation of phosphoprotein phosphatase activity; regulation of cell shape; peptidyl-serine phosphorylation; Wnt receptor signaling pathway; endocytosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.