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VRK3 (human)

Overview VRK3 Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. 2 human isoforms produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, CK1; CK1 group; VRK family Cellular Component: nucleus Molecular Function: protein phosphatase binding; ATP binding; protein kinase activity Biological Process: positive regulation of phosphoprotein phosphatase activity Reference #:  Q8IV63 (UniProtKB) Alt. Names/Synonyms: Serine/threonine-protein kinase VRK3; vaccinia related kinase 3; Vaccinia-related kinase 3; VRK3 Gene Symbols: VRK3 Molecular weight: 52,881 Da Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below VRK3 2JII - A/B=145-474 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	7		S55-p	SKRGLNSsFEtsPKK
0	3		T58-p	GLNSsFEtsPKKVKW
0	21		S59-p	LNSsFEtsPKKVKWs
0	1		S66-p	sPKKVKWssTVTSPR
0	1		S67-p	PKKVKWssTVTSPRL
0	1		S78	SPRLSLFSDGDssEs
0	6		S82-p	SLFSDGDssEsEDTL
0	7		S83-p	LFSDGDssEsEDTLs
0	3		S85-p	SDGDssEsEDTLsSS
0	1		S90-p	sEsEDTLsSSERSKG
0	1		S91	EsEDTLsSSERSKGS
0	5		T104-p	GSGSRPPtPKSsPQK
0	5		S108-p	RPPtPKSsPQKtRKs
0	3		-	gap
0	2		T112-p	PKSsPQKtRKsPQVt
0	7		S115-p	sPQKtRKsPQVtRGs
0	2		T119-p	tRKsPQVtRGsPQKt
0	5		S122-p	sPQVtRGsPQKtSCs
0	2		T126-p	tRGsPQKtSCsPQKT
0	3		S129-p	sPQKtSCsPQKTRQs
0	10		S136-p	sPQKTRQsPQTLKRS
0	1		T139	KTRQsPQTLKRSRVT
0	1		T154-p	TSLEALPtGtVLtDK
0	1		T156-p	LEALPtGtVLtDKSG
0	1		T159-p	LPtGtVLtDKSGRQW
0	1		K229-u	AKPLQVNkWKKLYST
0	1		K275-u	SALDVSPkHVLSERS
0	2		K410	QKQKFVDKPGPFVGP
0	1		-	gap

	VRK3 iso2
S55	SKRGLNSSFETSPKK
T58	GLNSSFETSPKKVKW
S59	LNSSFETSPKKVKWS
S66	SPKKVKWSSTVTSPR
S67	PKKVKWSSTVTSPRL
S78	SPRLSLFSDGDSSES
S82	SLFSDGDSSESEDTL
S83	LFSDGDSSESEDTLS
S85	SDGDSSESEDTLSSS
S90	SESEDTLSSSERSKG
S91	ESEDTLSSSERSKGS
T104	GSGSRPPTPKSSPQK
S108	RPPTPKSSPQKTRKS
-	gap
T112	PKSSPQKTRKSPQVT
S115	SPQKTRKSPQVTRGS
T119	TRKSPQVTRGSPQKT
S122	SPQVTRGSPQKTSCS
T126	TRGSPQKTSCSPQKT
S129	SPQKTSCSPQKTRQS
S136	SPQKTRQSPQTLKRS
T139	KTRQSPQTLKRSRVT
T154	TSLEALPTGTVLTDK
T156	LEALPTGTVLTDKSG
T159	LPTGTVLTDKSGRQW
K229	AKPLQVNKWKKLYST
K275	SALDVSPKHVLSERS
-	gap
S411-p	KQKLPWDsF______

	mouse
S55-p	SRRDLNSsFETsPKK
T58	DLNSsFETsPKKVKC
S59-p	LNSsFETsPKKVKCS
S66	sPKKVKCSHTVTSLP
H67	PKKVKCSHTVTSLPL
S78-p	SLPLSRHsDCDsSGs
S82-p	SRHsDCDsSGsDNTL
S83	RHsDCDsSGsDNTLT
S85-p	sDCDsSGsDNTLTsP
T90	SGsDNTLTsPDRATG
S91-p	GsDNTLTsPDRATGT
T104-p	GTRSRPLtPKGsPLs
S108-p	RPLtPKGsPLsNRQs
S111-p	tPKGsPLsNRQsPQt
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S115-p	sPLsNRQsPQtLKRT
T118-p	sNRQsPQtLKRTRVT
T133	TSLQALATGTELTDQ
T135	LQALATGTELTDQNG
T138	LATGTELTDQNGKHW
K208	AKPLQVNKWKKQFLL
K254	SALDDNPKHVVSERC
S389-p	QKQKYLDsPERLVGL
-	gap

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