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Protein Page:
VRK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VRK3 Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. 2 human isoforms produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CK1; CK1 group; VRK family
Cellular Component: nucleus
Molecular Function: protein phosphatase binding; ATP binding; protein kinase activity
Biological Process: positive regulation of phosphoprotein phosphatase activity; protein amino acid phosphorylation
Reference #:  Q8IV63 (UniProtKB)
Alt. Names/Synonyms: Serine/threonine-protein kinase VRK3; vaccinia related kinase 3; Vaccinia-related kinase 3; VRK3
Gene Symbols: VRK3
Molecular weight: 52,881 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VRK3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S54-p GSKRGLNssFEtsPK
0 9 S55-p SKRGLNssFEtsPKK
0 4 T58-p GLNssFEtsPKKVKW
0 26 S59-p LNssFEtsPKKVKWs
0 1 S66-p sPKKVKWssTVtsPR
0 1 S67-p PKKVKWssTVtsPRL
0 1 T70-p VKWssTVtsPRLSLF
0 1 S71-p KWssTVtsPRLSLFS
0 1 S78 sPRLSLFSDGDssEs
0 10 S82-p SLFSDGDssEsEDTL
0 12 S83-p LFSDGDssEsEDTLs
0 4 S85-p SDGDssEsEDTLsSS
0 1 T88 DssEsEDTLsSSERS
0 2 S90-p sEsEDTLsSSERSKG
0 1 S91 EsEDTLsSSERSKGS
0 5 T104-p GSGSRPPtPKSsPQK
0 6 S108-p RPPtPKSsPQKtRKs
0 3 - gap
0 2 T112-p PKSsPQKtRKsPQVt
0 8 S115-p sPQKtRKsPQVtRGs
0 3 T119-p tRKsPQVtRGsPQKt
0 7 S122-p sPQVtRGsPQKtSCs
0 2 T126-p tRGsPQKtSCsPQKT
0 3 S129-p sPQKtSCsPQKTRQs
0 11 S136-p sPQKTRQsPQTLKRS
0 1 T139 KTRQsPQTLKRSRVT
0 1 T154-p TSLEALPtGtVLtDK
0 1 T156-p LEALPtGtVLtDKSG
0 1 T159-p LPtGtVLtDKSGRQW
0 1 K229-ub AKPLQVNkWKKLYST
0 1 K275-ub SALDVSPkHVLSERS
0 1 F407 IMKQKQKFVDKPGPF
0 2 K410 QKQKFVDKPGPFVGP
0 1 - gap
  VRK3 iso2  
S54 GSKRGLNSSFETSPK
S55 SKRGLNSSFETSPKK
T58 GLNSSFETSPKKVKW
S59 LNSSFETSPKKVKWS
S66 SPKKVKWSSTVTSPR
S67 PKKVKWSSTVTSPRL
T70 VKWSSTVTSPRLSLF
S71 KWSSTVTSPRLSLFS
S78 SPRLSLFSDGDSSES
S82 SLFSDGDSSESEDTL
S83 LFSDGDSSESEDTLS
S85 SDGDSSESEDTLSSS
T88 DSSESEDTLSSSERS
S90 SESEDTLSSSERSKG
S91 ESEDTLSSSERSKGS
T104 GSGSRPPTPKSSPQK
S108 RPPTPKSSPQKTRKS
- gap
T112 PKSSPQKTRKSPQVT
S115 SPQKTRKSPQVTRGS
T119 TRKSPQVTRGSPQKT
S122 SPQVTRGSPQKTSCS
T126 TRGSPQKTSCSPQKT
S129 SPQKTSCSPQKTRQS
S136 SPQKTRQSPQTLKRS
T139 KTRQSPQTLKRSRVT
T154 TSLEALPTGTVLTDK
T156 LEALPTGTVLTDKSG
T159 LPTGTVLTDKSGRQW
K229 AKPLQVNKWKKLYST
K275 SALDVSPKHVLSERS
- gap
- gap
S411-p KQKLPWDsF______
  mouse

► Hide Isoforms
 
S54 GSRRDLNSsFETsPK
S55-p SRRDLNSsFETsPKK
T58 DLNSsFETsPKKVKC
S59-p LNSsFETsPKKVKCS
S66 sPKKVKCSHTVTSLP
H67 PKKVKCSHTVTSLPL
T70 VKCSHTVTSLPLSRH
S71 KCSHTVTSLPLSRHs
S78-p SLPLSRHsDCDsSGs
S82-p SRHsDCDsSGsDNTL
S83 RHsDCDsSGsDNTLT
S85-p sDCDsSGsDNTLTsP
T88 DsSGsDNTLTsPDRA
T90 SGsDNTLTsPDRATG
S91-p GsDNTLTsPDRATGT
T104-p GTRSRPLtPKGsPLs
S108-p RPLtPKGsPLsNRQs
S111-p tPKGsPLsNRQsPQt
- gap
- gap
- gap
- gap
- gap
- gap
S115-p sPLsNRQsPQtLKRT
T118-p sNRQsPQtLKRTRVT
T133 TSLQALATGTELTDQ
T135 LQALATGTELTDQNG
T138 LATGTELTDQNGKHW
K208 AKPLQVNKWKKQFLL
K254 SALDDNPKHVVSERC
Y386 ITRQKQKYLDsPERL
S389-p QKQKYLDsPERLVGL
- gap
  VRK3 iso3  
S54 GSRRDLNSSFETSPK
S55 SRRDLNSSFETSPKK
T58 DLNSSFETSPKKVKC
S59 LNSSFETSPKKVKCS
S66 SPKKVKCSHTVTSLP
H67 PKKVKCSHTVTSLPL
T70 VKCSHTVTSLPLSRH
S71 KCSHTVTSLPLSRHS
S78 SLPLSRHSDCDssGs
S82-p SRHSDCDssGsDNtL
S83-p RHSDCDssGsDNtLt
S85-p SDCDssGsDNtLtSP
T88-p DssGsDNtLtSPDRA
T90-p sGsDNtLtSPDRATA
S91 GsDNtLtSPDRATAE
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K143 AKPLQVNKWKKQFLL
- gap
- gap
- gap
- gap
  rat

 
S54 GSKRDLNSSSETSPK
S55 SKRDLNSSSETSPKK
T58 DLNSSSETSPKKVKW
S59 LNSSSETSPKKVKWS
S66 SPKKVKWSRTVTSLP
R67 PKKVKWSRTVTSLPL
T70 VKWSRTVTSLPLSLH
S71 KWSRTVTSLPLSLHS
S78 SLPLSLHSDYDSSGS
S82 SLHSDYDSSGSDDTL
S83 LHSDYDSSGSDDTLS
S85 SDYDSSGSDDTLSSP
T88 DSSGSDDTLSSPDRA
S90 SGSDDTLSSPDRATG
S91 GSDDTLSSPDRATGT
T104 GTRSRSQTPKGsPLA
S108-p RSQTPKGsPLANRLs
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S115-p sPLANRLsPRTLKRS
T118 ANRLsPRTLKRSRVT
T133 TSLQALPTGTELTDQ
T135 LQALPTGTELTDQNG
T138 LPTGTELTDQNGKHW
K208 AKPLQVNKWKKRCLT
K254 SALDDNPKHVVSERC
Y386-p ITKQKQKyQDNPEPL
N389 QKQKyQDNPEPLVGL
- gap
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