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Protein Page:
CFTR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CFTR a member of the MRP subfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. Functions as a chloride channel and controls the regulation of other transport pathways. Mutations have been observed in patients with the autosomal recessive disorders cystic fibrosis (CF) and congenital bilateral aplasia of the vas deferens (CBAVD). Alternative splice Note: This description may include information from UniProtKB.
Protein type: Transporter; Channel, chloride; Transporter, ABC family; Hydrolase; Membrane protein, integral; EC 3.6.3.49; Membrane protein, multi-pass
Cellular Component: microvillus; cell surface; cytoplasmic vesicle membrane; protein complex; early endosome membrane; basolateral plasma membrane; apical plasma membrane; early endosome; plasma membrane
Molecular Function: bicarbonate transmembrane transporter activity; chloride channel activity; protein binding; chloride channel inhibitor activity; enzyme binding; chloride transmembrane transporter activity; ATP-binding and phosphorylation-dependent chloride channel activity; channel-conductance-controlling ATPase activity; ATP binding; PDZ domain binding
Biological Process: ATP catabolic process; response to drug; intracellular pH elevation; response to peptide hormone stimulus; cholesterol transport; iodide transport; transepithelial chloride transport; water transport; membrane hyperpolarization; respiratory gaseous exchange; positive regulation of vasodilation; cholesterol biosynthetic process; vasodilation; cellular response to hormone stimulus; transport; bicarbonate transport; response to estrogen stimulus; response to cytokine stimulus; transmembrane transport; sperm capacitation; lung development
Reference #:  P13569 (UniProtKB)
Alt. Names/Synonyms: ABC35; ABCC7; ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; cAMP-dependent chloride channel; CF; CFTR; CFTR/MRP; Channel conductance-controlling ATPase; Cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); dJ760C5.1; MRP7; TNR-CFTR
Gene Symbols: CFTR
Molecular weight: 168,142 Da
Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CFTR

Protein Structure Not Found.


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Sites Implicated In
endocytosis, induced: S737‑p
activity, induced: S511‑p, T582‑p, T604‑p, S641‑p, S660‑p, T682‑p, S686‑p, S707‑p, S737‑p, S768‑p, S790‑p, S795‑p, S813‑p
activity, inhibited: S641‑p, T682‑p, S737‑p, S768‑p
enzymatic activity, inhibited: S660‑p, S700‑p, S712‑p, S737‑p, S768‑p, S795‑p, S813‑p
molecular association, regulation: S660‑p, S700‑p, S712‑p, S737‑p, S768‑p, S795‑p, S813‑p
protein conformation: S660‑p, S737‑p, S795‑p, S813‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S45-p YQIPSVDsADNLsEK
0 1 S50-p VDsADNLsEKLEREW
0 1 T94-p FLYLGEVtKAVQPLL
0 1 S256-p DQRAGKIsERLVITS
0 1 T291-p MIENLRQtELKLTRK
0 2 K420-ub KQNNNNRkTsNGDDS
3 0 S422-p NNNNRkTsNGDDSLF
2 0 S511-p ENIIFGVsyDEyRYR
2 0 Y512-p NIIFGVsyDEyRYRS
0 1 Y515-p FGVsyDEyRYRSVIK
0 1 Y517 VsyDEyRYRSVIKAC
0 1 S549-p GEGGITLsGGQRARI
2 0 T582-p FGYLDVLtEKEIFES
2 1 T604-p NKTRILVtsKMEHLK
0 1 S605-p KTRILVtsKMEHLKK
2 0 S641-p QNLQPDFsSKLMGCD
1 0 N659 QFSAERRNsILTETL
6 1 S660-p FSAERRNsILTETLH
3 0 S670 TETLHRFSLEGDAPV
2 0 T682-p APVSWTEtKKQsFKQ
4 0 S686-p WTEtKKQsFKQTGEF
6 1 S700-p FGEKRKNsILNPINs
2 0 S707-p sILNPINsIRKFsIV
4 0 S712-p INsIRKFsIVQKTPL
1 0 S728 MNGIEEDSDEPLERR
12 1 S737-p EPLERRLsLVPDSEQ
1 0 S742 RLsLVPDSEQGEAIL
2 0 S753-p EAILPRIsVISTGPT
10 1 S768-p LQARRRQsVLNLMtH
0 2 T774-p QsVLNLMtHsVNQGQ
0 2 S776-p VLNLMtHsVNQGQNI
2 0 S790-p IHRKTTAsTRKVsLA
5 1 S795-p TAsTRKVsLAPQANL
1 0 S809-p LTELDIYsRRLsQET
7 0 S813-p DIYsRRLsQETGLEI
1 0 T816 sRRLsQETGLEISEE
0 1 Y1014-p VVAVLQPyIFVAtVP
0 1 T1019-p QPyIFVAtVPVIVAF
0 1 T1176-p MPTEGKPtKSTKPYK
1 0 - gap
0 1 S1362-p CLARSVLsKAKILLL
0 1 Y1424-p EENKVRQyDSIQKLL
2 0 T1471-p IAALKEEtEEEVQDT
  mouse

 
S45 YQAPSADSADHLSEK
S50 ADSADHLSEKLEREW
T94 LLYLGEVTKAVQPVL
N256 DQRAAKINERLVITS
V291 MIENLREVELKMTRK
K420 QQSNGDRKHsSDENN
S422-p SNGDRKHsSDENNVS
S511 ENIIFGVSYDEYRYK
Y512 NIIFGVSYDEYRYKS
Y515 FGVSYDEYRYKSVVK
Y517 VSYDEYRYKSVVKAC
S549 GEGGVTLSGGQRARI
T582 FGYLDVFTEEQVFES
T604 NKTRILVTSKMEHLR
S605 KTRILVTSKMEHLRK
S641 QSLRPDFSSKLMGYD
S659-p QFTEERRssILTETL
S660-p FTEERRssILTETLR
S670-p TETLRRFsVDDSSAP
P681 SSAPWSKPKQSFRQT
S684 PWSKPKQSFRQTGEV
S698-p VGEKRKNsILNSFSS
S705 sILNSFSSVRKIsIV
S710-p FSSVRKIsIVQKTPL
S723-p PLCIDGEsDDLQEKR
S732-p DLQEKRLsLVPDsEQ
S737-p RLsLVPDsEQGEAAL
N748 EAALPRSNMIATGPT
S763-p FPGRRRQsVLDLMTF
T769 QsVLDLMTFTPNSGS
T771 VLDLMTFTPNSGSSN
S785 NLQRTRTSIRKIsLV
S790-p RTSIRKIsLVPQISL
S804 LNEVDVYSRRLsQDs
S808-p DVYSRRLsQDsTLNI
S811-p SRRLsQDsTLNITEE
Y1009 VVSALQPYIFLATVP
T1014 QPYIFLATVPGLVVF
T1172 QTEESMYTQIIKELP
S1183-p KELPREGsSDVLVIK
S1358 CLARSVLSKAKIILL
Y1420 EESNVWQYDSLQALL
T1467-p ITALKEEtEEEVQET
  rat

 
S45 YQAPSSDSADHLSEK
S50 SDSADHLSEKLEREW
T94 LLYLGEVTKAVQPVL
N256 DKRAAKINERLVITS
E291 IIESLREEELKMTRR
K420 QLNNDDRKTSNGENH
S422 NNDDRKTSNGENHLS
S511 ENIIFGVSYDEYRyK
Y512 NIIFGVSYDEYRyKS
Y515 FGVSYDEYRyKSVVK
Y517-p VSYDEYRyKSVVKAC
S549-p GEGGVTLsGGQRARI
T582 FGYLDVLTEEQIFES
T604 SKTRILVTSKMEQLK
S605 KTRILVTSKMEQLKK
S641 QSLRPDFSSKLMGYD
S659 QFTEERRSSILTETL
S660 FTEERRSSILTETLR
S670 TETLRRFSVDDASTT
A681 ASTTWNKAKQSFRQT
S684 TWNKAKQSFRQTGEF
S698 FGEKRKNSILSSFSS
S705 SILSSFSSVKKISIV
S710 FSSVKKISIVQKTPL
S723 PLSIEGESDDLQERR
S732 DLQERRLSLVPDSEH
S737 RLSLVPDSEHGEAAL
N748 EAALPRSNMITAGPT
S763 FPGRRRQSVLDLMTF
T769 QSVLDLMTFTPSSVS
T771 VLDLMTFTPSSVSSS
S785 SLQRTRASIRKISLA
S790 RASIRKISLAPRISL
S804 LKEEDIYSRRLsQDs
S808-p DIYSRRLsQDsTLNI
S811-p SRRLsQDsTLNITEE
Y1009 VVSALQPYIFLATVP
T1014 QPYIFLATVPGLAVF
- under review  
S1183 KELHSEDSPNALVIK
S1358 CLARSVLSKAKIILL
Y1420 EQGNVWQYESLQALL
T1467 ITAVKEETEEEVQET
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