a receptor type protein tyrosine phosphatase protein. Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The first PTPAse domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Specifically expressed in hematopoietic cells. An essential regulator of T- and B-cell antigen receptor signaling. Functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. Suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 188.8.131.52; Receptor protein phosphatase, tyrosine; Membrane protein, integral
Cellular Component: focal adhesion; cell surface; membrane; integral to plasma membrane; plasma membrane; integral to membrane; intracellular; cytosol; external side of plasma membrane
Molecular Function: heparin binding; heparan sulfate proteoglycan binding; protein binding; hydrolase activity; phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; protein kinase binding
Biological Process: B cell proliferation; positive regulation of isotype switching to IgG isotypes; positive regulation of T cell mediated cytotoxicity; regulation of humoral immune response mediated by circulating immunoglobulin; activation of MAPK activity; regulation of cell cycle; protein amino acid dephosphorylation; T cell receptor signaling pathway; T cell proliferation; leukocyte adhesion; B cell receptor signaling pathway; positive regulation of MAPKKK cascade; negative regulation of T cell mediated cytotoxicity; positive regulation of B cell proliferation; response to gamma radiation; positive regulation of T cell mediated immunity; negative regulation of protein amino acid autophosphorylation; negative regulation of cytokine and chemokine mediated signaling pathway; positive regulation of T cell proliferation; positive regulation of gamma-delta T cell differentiation; defense response to virus; T cell differentiation; positive thymic T cell selection; regulation of B cell receptor signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of humoral immune response mediated by circulating immunoglobulin; substrate-bound cell migration, cell release from substrate; positive regulation of antigen receptor-mediated signaling pathway; negative thymic T cell selection; bone marrow development; heterotypic cell-cell adhesion; stem cell development; positive regulation of T cell differentiation; dephosphorylation; release of sequestered calcium ion into cytosol; B cell differentiation; regulation of B cell differentiation; negative regulation of protein kinase activity; hemopoietic progenitor cell differentiation; positive regulation of alpha-beta T cell proliferation; immunoglobulin biosynthetic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.