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Protein Page:
CD45 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD45 a receptor type protein tyrosine phosphatase protein. Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The first PTPAse domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Specifically expressed in hematopoietic cells. An essential regulator of T- and B-cell antigen receptor signaling. Functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. Suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.3.48; Receptor protein phosphatase, tyrosine
Cellular Component: focal adhesion; cell surface; membrane; integral to plasma membrane; integral to membrane; plasma membrane; intracellular; cytosol; external side of plasma membrane
Molecular Function: heparan sulfate proteoglycan binding; heparin binding; protein binding; hydrolase activity; phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; protein kinase binding
Biological Process: B cell proliferation; positive regulation of isotype switching to IgG isotypes; regulation of humoral immune response mediated by circulating immunoglobulin; activation of MAPK activity; regulation of cell cycle; positive regulation of T cell mediated cytotoxicity; protein amino acid dephosphorylation; T cell receptor signaling pathway; T cell proliferation; leukocyte adhesion; B cell receptor signaling pathway; positive regulation of MAPKKK cascade; negative regulation of T cell mediated cytotoxicity; positive regulation of B cell proliferation; positive regulation of T cell mediated immunity; response to gamma radiation; negative regulation of protein amino acid autophosphorylation; positive regulation of T cell proliferation; negative regulation of cytokine and chemokine mediated signaling pathway; positive regulation of gamma-delta T cell differentiation; defense response to virus; T cell differentiation; positive thymic T cell selection; regulation of B cell receptor signaling pathway; positive regulation of humoral immune response mediated by circulating immunoglobulin; negative regulation of peptidyl-tyrosine phosphorylation; substrate-bound cell migration, cell release from substrate; positive regulation of antigen receptor-mediated signaling pathway; negative thymic T cell selection; bone marrow development; heterotypic cell-cell adhesion; stem cell development; dephosphorylation; positive regulation of T cell differentiation; B cell differentiation; release of sequestered calcium ion into cytosol; regulation of B cell differentiation; negative regulation of protein kinase activity; positive regulation of alpha-beta T cell proliferation; hemopoietic progenitor cell differentiation; immunoglobulin biosynthetic process
Reference #:  P06800 (UniProtKB)
Alt. Names/Synonyms: B220; Cd45; CD45R; L-CA; Leukocyte common antigen; loc; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; protein tyrosine phosphatase, receptor type, C; Ptprc; Receptor-type tyrosine-protein phosphatase C; T200
Gene Symbols: Ptprc
Molecular weight: 144,604 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Select Structure to View Below

CD45

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S988‑p, S991‑p, S992‑p, S996‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 N253 EECSQIKNISVSNDS
0 1 N426 EKCKSLPNNVTSFEV
0 1 Y442 SLKPYKYYEVSLLAY
0 1 S445 PYKYYEVSLLAYVNG
0 1 Y533 FYVDNLYYSTDYEFL
0 1 Y537 NLYYSTDYEFLVSFH
0 1 Y548 VSFHNGVYEGDSVIR
0 7 S646 LFLAEFQSIPRVFsK
0 4 S652-p QSIPRVFsKFPIKDA
0 3 K653 SIPRVFsKFPIKDAR
0 18 Y670-p HNQNKNRyVDILPYD
0 2 Y676 RyVDILPYDYNRVEL
0 1 Y678 VDILPYDYNRVELSE
0 4 Y694 NGDAGSTYINASYID
0 5 Y699 STYINASYIDGFkEP
0 9 K704-ub ASYIDGFkEPRKYIA
0 11 Y752 NRNKCAEYWPSMEEG
0 4 K774-ub VVTINDHkRCPDYII
0 6 Y779 DHkRCPDYIIQKLNV
0 1 T847 CSAGVGRTGTYIGID
0 1 T849 AGVGRTGTYIGIDAM
0 1 Y850 GVGRTGTYIGIDAML
0 1 Y869 AEGKVDVYGYVVKLR
0 1 Y889 MVQVEAQYILIHQAL
0 1 C915 NLSELHSCLHNMKKR
0 1 S926 MKKRDPPSDPSPLEA
0 3 Y935-p PSPLEAEyQRLPSYR
0 3 S940 AEyQRLPSYRSWRTQ
0 2 K956 IGNQEENKkkNRNsN
0 2 K957-ub GNQEENKkkNRNsNV
0 2 K958-ub NQEENKkkNRNsNVV
0 109 S962-p NKkkNRNsNVVPYDF
0 14 Y967 RNsNVVPYDFNRVPL
0 114 F969 sNVVPYDFNRVPLKH
0 2 S981 LKHELEMSKESEPEs
0 2 S984 ELEMSKESEPEsDEs
1 2 S988-p SKESEPEsDEssDDD
1 3 S991-p SEPEsDEssDDDsDS
1 4 S992-p EPEsDEssDDDsDSE
1 2 S996-p DEssDDDsDSEETSK
0 1 R1082 VEMKDTNRASAYTLR
0 1 R1082 VEMKDTNRASAYTLR
0 1 K1113-ub QYQCTTWkGEELPAE
0 1 S1139-p KQKLPKAsPEGMKYH
1 1 Y1204 VVCSYEQYQFLYDII
0 1 Y1208 YEQYQFLYDIIASIY
0 4 T1225-p QNGQVKKtNsQDKIE
0 5 S1227-p GQVKKtNsQDKIEFH
0 2 T1265-p EDSRGVGtPEPtNsA
0 1 P1266 DSRGVGtPEPtNsAE
0 1 T1269-p GVGtPEPtNsAEEPE
0 1 S1271-p GtPEPtNsAEEPEHA
0 1 A1272 tPEPtNsAEEPEHAA
0 1 A1278 sAEEPEHAANGsAsP
0 1 S1282-p PEHAANGsAsPAPTQ
0 14 S1284-p HAANGsAsPAPTQSS
  human

 
S278-p LTECKNAsVSISHNS
K437-ac KDCLNLDkNLIKYDL
Y453-p NLKPYTKyVLsLHAY
S456-p PYTKyVLsLHAYIIA
Y544-p FRVKDLQySTDyTFK
Y548-p DLQySTDyTFKAYFH
Y559-p AYFHNGDyPGEPFIL
S657-p LFLAEFQsIPRVFsk
S663-p QsIPRVFskFPIKEA
K664-ub sIPRVFskFPIKEAR
Y681-p FNQNKNRyVDILPyD
Y687-p RyVDILPyDyNRVEL
Y689-p VDILPyDyNRVELSE
Y705-p NGDAGSNyINASyID
Y710-p SNyINASyIDGFkEP
K715-ub ASyIDGFkEPRKYIA
Y763-p NRNKCAEyWPSMEEG
K785 VVKINQHKRCPDyII
Y790-p QHKRCPDyIIQKLNI
T858-p CSAGVGRtGtyIGID
T860-p AGVGRtGtyIGIDAM
Y861-p GVGRtGtyIGIDAML
Y880-p AENKVDVyGYVVKLR
Y900-p MVQVEAQyILIHQAL
Y926-p NLSELHPyLHNMKKR
S937-p MKKRDPPsEPSPLEA
F946 PSPLEAEFQRLPsYR
S951-p AEFQRLPsYRSWRTQ
K967-ub IGNQEENkSKNRNsN
S968 GNQEENkSKNRNsNV
K969 NQEENkSKNRNsNVI
S973-p NkSKNRNsNVIPyDy
Y978-p RNsNVIPyDyNRVPL
Y980-p sNVIPyDyNRVPLKH
S992-p LKHELEMsKEsEHDs
S995-p ELEMsKEsEHDsDEs
S999-p sKEsEHDsDEssDDD
S1002-p sEHDsDEssDDDsDS
S1003-p EHDsDEssDDDsDSE
S1007-p DEssDDDsDSEEPSK
K1093-ac VDLKDTDkSSTYTLR
K1093-ub VDLKDTDkSSTYTLR
S1124 QYQYTNWSVEQLPAE
S1151 QKLPQKNSSEGNKHH
Y1216-p MVSTFEQyQFLyDVI
Y1220-p FEQyQFLyDVIASTY
N1237 QNGQVKKNNHQEDKI
H1239 GQVKKNNHQEDKIEF
G1278 EAKEQAEGsEPTSGt
S1279-p AKEQAEGsEPTSGtE
T1282 QAEGsEPTSGtEGPE
G1284 EGsEPTSGtEGPEHs
T1285-p GsEPTSGtEGPEHsV
S1291-p GtEGPEHsVNGPAsP
P1295 PEHsVNGPAsPALNQ
S1297-p HsVNGPAsPALNQGS
  rat

 
N245 LPECSQKNVTLSNGS
N408 EKCENLANDVNSFEV
Y424 NLRPYTEYTVSLFAY
S427 PYTEYTVSLFAYVIG
Y515 FVVDNLYYSTDYEFL
Y519 NLYYSTDYEFLVYFY
Y530 VYFYNGEYLGDPEIK
S628 LFLAEFQSIPRVFSK
S634 QSIPRVFSKFPIKDA
K635 SIPRVFSKFPIKDAR
Y652-p QNQNKNRyVDILPYD
Y658 RyVDILPYDYNRVEL
Y660 VDILPYDYNRVELSE
Y676 NGDAGSTYINASYID
Y681 STYINASYIDGFKEP
K686 ASYIDGFKEPRKYIA
Y734 NRNKCAEYWPCMEEG
K756 VVTINDHKRCPDYII
Y761 DHKRCPDYIIQKLSI
T829 CSAGVGRTGTYIGID
T831 AGVGRTGTYIGIDAM
Y832 GVGRTGTYIGIDAML
Y851 AEGKVDVYGYVVNLR
Y871 MVQVEAQYILIHQAL
C897 NLSELHSCLQNLKKR
S908 LKKRDPPSDPSPLEA
Y917 PSPLEAEYQRLPSYR
S922 AEYQRLPSYRSWRTQ
K938 IGNQEENKKKNRSsN
K939 GNQEENKKKNRSsNV
K940 NQEENKKKNRSsNVV
S944-p NKKKNRSsNVVPYDF
Y949 RSsNVVPYDFNRVPL
F951 sNVVPYDFNRVPLKH
S963-p LKHELEMsKEsEAEs
S966-p ELEMsKEsEAEsDEs
S970-p sKEsEAEsDEssDED
S973-p sEAEsDEssDEDsDS
S974-p EAEsDEssDEDsDSE
S978-p DEssDEDsDSEETSK
K1064 VMLKDTNKSSAYILR
K1064 VMLKDTNKSSAYILR
K1095 QYQCTTWKGEELPAE
G1121 KQKLPKSGSEGMKYH
Y1186 MVGSFEQYQFLYDIM
Y1190 FEQYQFLYDIMASIY
A1207 QNGQVKKANsQDKIE
S1209-p GQVKKANsQDKIEFH
A1247 EDSKEVGASEPASGS
S1248 DSKEVGASEPASGSE
A1251 EVGASEPASGSEEPE
G1253 GASEPASGSEEPEHS
S1254 ASEPASGSEEPEHSA
S1260 GSEEPEHSANGPMSP
P1264 PEHSANGPMSPALTP
S1266 HSANGPMSPALTPSS
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