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Protein Page:
CD45 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD45 a receptor type protein tyrosine phosphatase protein. Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The first PTPAse domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Specifically expressed in hematopoietic cells. An essential regulator of T- and B-cell antigen receptor signaling. Functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. Suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; EC 3.1.3.48; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q31-q32
Cellular Component: focal adhesion; membrane; integral to plasma membrane; plasma membrane; lipid raft; external side of plasma membrane
Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; protein kinase binding
Biological Process: B cell proliferation; axon guidance; substrate-bound cell migration, cell release from substrate; regulation of cell cycle; protein amino acid dephosphorylation; positive regulation of antigen receptor-mediated signaling pathway; T cell receptor signaling pathway; bone marrow development; stem cell development; B cell receptor signaling pathway; cell surface receptor linked signal transduction; dephosphorylation; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; negative regulation of T cell mediated cytotoxicity; positive regulation of B cell proliferation; negative regulation of protein kinase activity; negative regulation of cytokine and chemokine mediated signaling pathway; hemopoietic progenitor cell differentiation; positive regulation of T cell proliferation; immunoglobulin biosynthetic process; defense response to virus; T cell differentiation
Reference #:  P08575 (UniProtKB)
Alt. Names/Synonyms: B220; CD45; CD45 antigen; CD45R; glycoprotein; GP180; L-CA; LCA; Leukocyte common antigen; leukocyte-common antigen; LY5; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen
Gene Symbols: PTPRC
Molecular weight: 147,254 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD45

Protein Structure Not Found.


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Sites Implicated In
activity, induced: Y1216‑p
molecular association, regulation: Y1216‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S278-p LTECKNAsVSISHNS
0 1 K437-ac KDCLNLDkNLIKYDL
0 1 Y453-p NLKPYTKyVLsLHAY
0 1 S456-p PYTKyVLsLHAYIIA
0 1 Y544-p FRVKDLQySTDyTFK
0 1 Y548-p DLQySTDyTFKAYFH
0 1 Y559-p AYFHNGDyPGEPFIL
0 7 S657-p LFLAEFQsIPRVFsk
0 4 S663-p QsIPRVFskFPIKEA
0 3 K664-ub sIPRVFskFPIKEAR
0 18 Y681-p FNQNKNRyVDILPyD
0 2 Y687-p RyVDILPyDyNRVEL
0 1 Y689-p VDILPyDyNRVELSE
0 4 Y705-p NGDAGSNyINASyID
0 5 Y710-p SNyINASyIDGFkEP
0 9 K715-ub ASyIDGFkEPRKYIA
0 11 Y763-p NRNKCAEyWPSMEEG
0 4 K785 VVKINQHKRCPDyII
0 6 Y790-p QHKRCPDyIIQKLNI
0 1 T858-p CSAGVGRtGtyIGID
0 1 T860-p AGVGRtGtyIGIDAM
0 1 Y861-p GVGRtGtyIGIDAML
0 1 Y880-p AENKVDVyGYVVKLR
0 1 Y900-p MVQVEAQyILIHQAL
0 1 Y926-p NLSELHPyLHNMKKR
0 1 S937-p MKKRDPPsEPSPLEA
0 3 F946 PSPLEAEFQRLPsYR
0 3 S951-p AEFQRLPsYRSWRTQ
0 2 K967-ub IGNQEENkSKNRNsN
0 2 S968 GNQEENkSKNRNsNV
0 2 K969 NQEENkSKNRNsNVI
0 111 S973-p NkSKNRNsNVIPyDy
0 14 Y978-p RNsNVIPyDyNRVPL
0 114 Y980-p sNVIPyDyNRVPLKH
0 2 S992-p LKHELEMsKEsEHDs
0 2 S995-p ELEMsKEsEHDsDEs
1 2 S999-p sKEsEHDsDEssDDD
1 3 S1002-p sEHDsDEssDDDsDS
1 4 S1003-p EHDsDEssDDDsDSE
1 2 S1007-p DEssDDDsDSEEPSK
0 1 K1093-ac VDLKDTDkSSTYTLR
0 1 K1093-ub VDLKDTDkSSTYTLR
0 1 S1124 QYQYTNWSVEQLPAE
0 1 S1151 QKLPQKNSSEGNKHH
1 1 Y1216-p MVSTFEQyQFLyDVI
0 1 Y1220-p FEQyQFLyDVIASTY
0 4 N1237 QNGQVKKNNHQEDKI
0 6 H1239 GQVKKNNHQEDKIEF
0 3 G1278 EAKEQAEGsEPTSGt
0 1 S1279-p AKEQAEGsEPTSGtE
0 1 T1282 QAEGsEPTSGtEGPE
0 1 G1284 EGsEPTSGtEGPEHs
0 1 T1285-p GsEPTSGtEGPEHsV
0 1 S1291-p GtEGPEHsVNGPAsP
0 1 P1295 PEHsVNGPAsPALNQ
0 14 S1297-p HsVNGPAsPALNQGS
  mouse

 
N253 EECSQIKNISVSNDS
N426 EKCKSLPNNVTSFEV
Y442 SLKPYKYYEVSLLAY
S445 PYKYYEVSLLAYVNG
Y533 FYVDNLYYSTDYEFL
Y537 NLYYSTDYEFLVSFH
Y548 VSFHNGVYEGDSVIR
S646 LFLAEFQSIPRVFsK
S652-p QSIPRVFsKFPIKDA
K653 SIPRVFsKFPIKDAR
Y670-p HNQNKNRyVDILPYD
Y676 RyVDILPYDYNRVEL
Y678 VDILPYDYNRVELSE
Y694 NGDAGSTYINASYID
Y699 STYINASYIDGFkEP
K704-ub ASYIDGFkEPRKYIA
Y752 NRNKCAEYWPSMEEG
K774-ub VVTINDHkRCPDYII
Y779 DHkRCPDYIIQKLNV
T847 CSAGVGRTGTYIGID
T849 AGVGRTGTYIGIDAM
Y850 GVGRTGTYIGIDAML
Y869 AEGKVDVYGYVVKLR
Y889 MVQVEAQYILIHQAL
C915 NLSELHSCLHNMKKR
S926 MKKRDPPSDPSPLEA
Y935-p PSPLEAEyQRLPSYR
S940 AEyQRLPSYRSWRTQ
K956 IGNQEENKkkNRNsN
K957-ub GNQEENKkkNRNsNV
K958-ub NQEENKkkNRNsNVV
S962-p NKkkNRNsNVVPYDF
Y967 RNsNVVPYDFNRVPL
F969 sNVVPYDFNRVPLKH
S981 LKHELEMSKESEPEs
S984 ELEMSKESEPEsDEs
S988-p SKESEPEsDEssDDD
S991-p SEPEsDEssDDDsDS
S992-p EPEsDEssDDDsDSE
S996-p DEssDDDsDSEETSK
R1082 VEMKDTNRASAYTLR
R1082 VEMKDTNRASAYTLR
K1113-ub QYQCTTWkGEELPAE
S1139-p KQKLPKAsPEGMKYH
Y1204 VVCSYEQYQFLYDII
Y1208 YEQYQFLYDIIASIY
T1225-p QNGQVKKtNsQDKIE
S1227-p GQVKKtNsQDKIEFH
T1265-p EDSRGVGtPEPtNsA
P1266 DSRGVGtPEPtNsAE
T1269-p GVGtPEPtNsAEEPE
S1271-p GtPEPtNsAEEPEHA
A1272 tPEPtNsAEEPEHAA
A1278 sAEEPEHAANGsAsP
S1282-p PEHAANGsAsPAPTQ
S1284-p HAANGsAsPAPTQSS
  rat

 
N245 LPECSQKNVTLSNGS
N408 EKCENLANDVNSFEV
Y424 NLRPYTEYTVSLFAY
S427 PYTEYTVSLFAYVIG
Y515 FVVDNLYYSTDYEFL
Y519 NLYYSTDYEFLVYFY
Y530 VYFYNGEYLGDPEIK
S628 LFLAEFQSIPRVFSK
S634 QSIPRVFSKFPIKDA
K635 SIPRVFSKFPIKDAR
Y652-p QNQNKNRyVDILPYD
Y658 RyVDILPYDYNRVEL
Y660 VDILPYDYNRVELSE
Y676 NGDAGSTYINASYID
Y681 STYINASYIDGFKEP
K686 ASYIDGFKEPRKYIA
Y734 NRNKCAEYWPCMEEG
K756 VVTINDHKRCPDYII
Y761 DHKRCPDYIIQKLSI
T829 CSAGVGRTGTYIGID
T831 AGVGRTGTYIGIDAM
Y832 GVGRTGTYIGIDAML
Y851 AEGKVDVYGYVVNLR
Y871 MVQVEAQYILIHQAL
C897 NLSELHSCLQNLKKR
S908 LKKRDPPSDPSPLEA
Y917 PSPLEAEYQRLPSYR
S922 AEYQRLPSYRSWRTQ
K938 IGNQEENKKKNRSsN
K939 GNQEENKKKNRSsNV
K940 NQEENKKKNRSsNVV
S944-p NKKKNRSsNVVPYDF
Y949 RSsNVVPYDFNRVPL
F951 sNVVPYDFNRVPLKH
S963-p LKHELEMsKEsEAEs
S966-p ELEMsKEsEAEsDEs
S970-p sKEsEAEsDEssDED
S973-p sEAEsDEssDEDsDS
S974-p EAEsDEssDEDsDSE
S978-p DEssDEDsDSEETSK
K1064 VMLKDTNKSSAYILR
K1064 VMLKDTNKSSAYILR
K1095 QYQCTTWKGEELPAE
G1121 KQKLPKSGSEGMKYH
Y1186 MVGSFEQYQFLYDIM
Y1190 FEQYQFLYDIMASIY
A1207 QNGQVKKANsQDKIE
S1209-p GQVKKANsQDKIEFH
A1247 EDSKEVGASEPASGS
S1248 DSKEVGASEPASGSE
A1251 EVGASEPASGSEEPE
G1253 GASEPASGSEEPEHS
S1254 ASEPASGSEEPEHSA
S1260 GSEEPEHSANGPMSP
P1264 PEHSANGPMSPALTP
S1266 HSANGPMSPALTPSS
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