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Protein Page:
NOTCH3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NOTCH3 Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Heterodimer of a C-terminal fragment N(TM) and a N- terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with PSMA1. Interacts with HIF1AN. Ubiquitously expressed in fetal and adult tissues. Belongs to the NOTCH family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13.2-p13.1
Cellular Component: nucleoplasm; Golgi membrane; endoplasmic reticulum membrane; cytoplasm; plasma membrane; integral to membrane; extracellular region; nucleolus; nucleus; cytosol; receptor complex; actin cytoskeleton
Molecular Function: protein binding; enzyme binding; calcium ion binding
Biological Process: transcription initiation from RNA polymerase II promoter; negative regulation of neuron differentiation; Notch signaling pathway; regulation of transcription, DNA-dependent; positive regulation of smooth muscle cell proliferation; forebrain development; neuron fate commitment; Notch receptor processing; gene expression
Reference #:  Q9UM47 (UniProtKB)
Alt. Names/Synonyms: CADASIL; CASIL; Neurogenic locus notch homolog protein 3; NOTC3; Notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch homolog 3 (Drosophila); NOTCH3
Gene Symbols: NOTCH3
Molecular weight: 243,631 Da
Basal Isoelectric point: 5.18  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NOTCH3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S84-p QLEDPCHsGPCAGRG
0 1 S118-p GFRGPDCsLPDPCLs
0 1 S125-p sLPDPCLssPCAHGA
0 1 S126-p LPDPCLssPCAHGAR
0 1 S135-p CAHGARCsVGPDGRF
0 1 T211-p SPCRNGGtCRQSGDL
0 1 Y529-p CVDQPDGyECRCAEG
0 1 Y1197-p RCTCPPGyTGLRCEA
0 1 S1672-p ARRKREHsTLWFPEG
0 1 S1681-p LWFPEGFsLHkDVAS
0 1 K1684-ub PEGFsLHkDVASGHK
1 0 K1691 kDVASGHKGRREPVG
1 0 K1730 DTECPEAKRLKVEEP
0 1 Y1849-p ALHLAARyARADAAK
0 1 T1908-p ARMADGStALILAAR
0 1 S2032-p DQPSGPRsPPGPHGL
0 1 R2174-m1 AVPLDWArLPPPAPP
  mouse

 
S85 QLEDPCHSGPCAGRG
S119 GFQGPDCSQPDPCVS
S126 SQPDPCVSRPCVHGA
R127 QPDPCVSRPCVHGAP
S136 CVHGAPCSVGPDGRF
T212 SPCRNGGTCRQSSDV
Y530 CVDQPDGYECRCAEG
Y1198 RCNCPPGYTGLHCEA
S1673 ARRKREHSTLWFPEG
A1682 LWFPEGFALHKDIAA
K1685 PEGFALHKDIAAGHk
K1692-ac KDIAAGHkGRREPVG
K1731-ac DSECPEAkRLKVEEP
Y1850 ALHLAARYARADAAK
T1909 ARMADGSTALILAAR
S2033 DQPSGPRSPSGPHGL
R2174 AVPLDWARLPPPAPP
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