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NOTCH3 (human)

Overview NOTCH3 Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Heterodimer of a C-terminal fragment N(TM) and a N- terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with PSMA1. Interacts with HIF1AN. Ubiquitously expressed in fetal and adult tissues. Belongs to the NOTCH family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: nucleoplasm; Golgi membrane; endoplasmic reticulum membrane; extracellular region; plasma membrane; integral to membrane; cytosol Molecular Function: protein binding; enzyme binding; calcium ion binding Biological Process: transcription initiation from RNA polymerase II promoter; negative regulation of neuron differentiation; Notch signaling pathway; regulation of transcription, DNA-dependent; tissue regeneration; positive regulation of smooth muscle cell proliferation; forebrain development; neuron fate commitment; Notch receptor processing; gene expression Reference #:  Q9UM47 (UniProtKB) Alt. Names/Synonyms: CADASIL; CASIL; Neurogenic locus notch homolog protein 3; NOTC3; Notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch homolog 3 (Drosophila); NOTCH3 Gene Symbols: NOTCH3 Molecular weight: 243,631 Da Basal Isoelectric point: 5.18  Predict pI for various phosphorylation states CST Pathways:  ESC Pluripotency and Differentiation  |  Notch Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NOTCH3

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE 125310 600276  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S84-p	QLEDPCHsGPCAGRG
0	1		T211-p	SPCRNGGtCRQSGDL
0	1		Y529-p	CVDQPDGyECRCAEG
0	1		Y1197-p	RCTCPPGyTGLRCEA
0	1		S1672-p	ARRKREHsTLWFPEG
0	1		K1684-u	PEGFSLHkDVASGHK
0	1		Y1849-p	ALHLAARyARADAAK
0	1		T1908-p	ARMADGStALILAAR

	mouse
S85	QLEDPCHSGPCAGRG
T212	SPCRNGGTCRQSSDV
Y530	CVDQPDGYECRCAEG
Y1198	RCNCPPGYTGLHCEA
S1673	ARRKREHSTLWFPEG
K1685	PEGFALHKDIAAGHK
Y1850	ALHLAARYARADAAK
T1909	ARMADGSTALILAAR

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