IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. Belongs to the IFIT family. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 10q23.31
Cellular Component: cytoplasm; cytosol
Molecular Function: protein binding; RNA binding
Biological Process: intracellular transport of viral proteins in host cell; negative regulation of helicase activity; positive regulation of viral genome replication; negative regulation of viral genome replication; cytokine and chemokine mediated signaling pathway; response to virus; negative regulation of defense response to virus by host; negative regulation of protein binding; defense response to virus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.