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NOD1
Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction. Interacts with ARHGEF2. Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon. Note: This description may include information from UniProtKB.
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Cellular Component: basolateral plasma membrane; cytoplasm; cytosol
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Molecular Function: identical protein binding; peptidoglycan binding; protein binding; protein homodimerization activity; CARD domain binding; caspase activator activity; ATP binding
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Biological Process: detection of bacterium; apoptosis; activation of MAPK activity; positive regulation of dendritic cell antigen processing and presentation; stress-activated MAPK cascade; positive regulation of JNK cascade; defense response; toll-like receptor 3 signaling pathway; signal transduction; activation of NF-kappaB transcription factor; interleukin-8 biosynthetic process; JNK cascade; detection of biotic stimulus; inflammatory response; toll-like receptor 4 signaling pathway; caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; Toll signaling pathway; protein oligomerization; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-positive bacterium; induction of apoptosis; defense response to bacterium; toll-like receptor signaling pathway; innate immune response
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Reference #:
Q9Y239 (UniProtKB)
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| Alt. Names/Synonyms: CARD4; caspase recruitment domain family, member 4; Caspase recruitment domain-containing protein 4; CLR7.1; NLR family, CARD domain containing 1; NLRC1; NOD1; nucleotide-binding oligomerization domain containing 1; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1; Nucleotide-binding oligomerization domain-containing protein 1 |
| Gene Symbols: NOD1 |
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Molecular weight: 107,691 Da
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Basal Isoelectric point: 6.71
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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