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K19 (human)

Overview K19 a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 differs from all other IF proteins in lacking the C-terminal tail domain. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: dystrophin-associated glycoprotein complex; costamere; intermediate filament; Z disc; sarcolemma Molecular Function: protein binding; structural constituent of cytoskeleton; structural constituent of muscle Biological Process: response to estrogen stimulus; virus-host interaction; sarcomere organization Reference #:  P08727 (UniProtKB) Alt. Names/Synonyms: 40-kDa keratin intermediate filament; CK-19; CK19; cytokeratin 19; Cytokeratin-19; K19; K1C19; K1CS; keratin 19; Keratin, type I cytoskeletal 19; keratin, type I, 40-kd; Keratin-19; KRT19; MGC15366 Gene Symbols: KRT19 Molecular weight: 44,106 Da Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below K19

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	Sites Implicated In
cytoskeletal reorganization: S35‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		R7-m1	_MTSYSYrQSsAtSs
0	1		R7-m2	_MTSYSYrQSsAtSs
0	1		S9	TSYSYrQSsAtSsFG
0	22		S10-p	SYSYrQSsAtSsFGG
0	5		T12-p	SYrQSsAtSsFGGLG
0	2		S13	YrQSsAtSsFGGLGG
0	4		S14-p	rQSsAtSsFGGLGGG
0	3		S22-p	FGGLGGGsVrFGPGV
0	11		R24-m1	GLGGGsVrFGPGVAF
0	5		R24-m2	GLGGGsVrFGPGVAF
0	2		P27	GGsVrFGPGVAFrAP
0	15		R32-m1	FGPGVAFrAPsIHGG
2	106		S35-p	GVAFrAPsIHGGsGG
0	16		S40-p	APsIHGGsGGrGVsV
0	24		R43-m1	IHGGsGGrGVsVSsA
0	2		R43-m2	IHGGsGGrGVsVSsA
0	1		S46-p	GsGGrGVsVSsArFV
0	1		S49-p	GrGVsVSsArFVSsS
0	16		R51-m1	GVsVSsArFVSsSSs
0	1		S54	VSsArFVSsSSsGAy
0	3		S55-p	SsArFVSsSSsGAyG
0	12		S58-p	rFVSsSSsGAyGGGy
0	7		-	gap
0	16		Y61-p	SsSSsGAyGGGyGGV
0	10		Y61	SsSSsGAYGGGyGGV
0	3		G64	SsGAyGGGyGGVLTA
0	4		Y65-p	sGAyGGGyGGVLTAs
0	4		S72-p	yGGVLTAsDGLLAGN
0	1		K81-u	GLLAGNEkLTMQNLN
0	6		S93-p	NLNDRLAsyLDkVRA
0	89		Y94-p	LNDRLAsyLDkVRAL
0	6		K97-u	RLAsyLDkVRALEAA
0	1		K111-u	ANGELEVkIRDWyQk
0	27		Y116-p	EVkIRDWyQkQGPGP
0	6		K118-u	kIRDWyQkQGPGPSR
0	21		Y130-p	PSRDYSHyyTTIQDL
0	2		Y131-p	SRDYSHyyTTIQDLR
0	1		K140-u	TIQDLRDkILGAtIE
0	1		T145-p	RDkILGAtIENSRIV
0	7		K168-u	AADDFRTkFETEQAL
1	0		K208-s	EMQIEGLkEELAyLk
0	3		K208-u	EMQIEGLkEELAyLk
0	1		Y213-p	GLkEELAyLkkNHEE
0	1		K215-u	kEELAyLkkNHEEEI
0	5		K216-u	EELAyLkkNHEEEIS
0	1		K247-u	APGTDLAkILSDMRS
0	55		Y256-p	LSDMRSQyEVMAEQN
0	1		K265-u	VMAEQNRkDAEAWFT
0	1		S273-p	DAEAWFTsRtEELNR
0	2		T275-p	EAWFTsRtEELNREV
0	2		S312-p	GLEIELQsQLSMkAA
0	1		K317-u	LQsQLSMkAALEDTL
0	1		K370-u	YQRLMDIkSRLEQEI
0	4		R372	RLMDIkSRLEQEIAT
0	10		Y380-p	LEQEIATyRSLLEGQ
1	209		Y391-p	LEGQEDHyNNLsASk
0	1		N393	GQEDHyNNLsASkVL
0	3		S395-p	EDHyNNLsASkVL__
0	1		A396	DHyNNLsASkVL___
0	8		K398-u	yNNLsASkVL_____

	mouse
R7	_MTSYSYRQTSAMsS
R7	_MTSYSYRQTSAMsS
T9	TSYSYRQTSAMsSFG
S10	SYSYRQTSAMsSFGG
M12	SYRQTSAMsSFGGTG
S13-p	YRQTSAMsSFGGTGG
S14	RQTSAMsSFGGTGGG
S22	FGGTGGGSVRIGsGG
R24	GTGGGSVRIGsGGVF
R24	GTGGGSVRIGsGGVF
S27-p	GGSVRIGsGGVFRAP
R32	IGsGGVFRAPsIHGG
S35-p	GGVFRAPsIHGGSGG
S40	APsIHGGSGGrGVSV
R43-m1	IHGGSGGrGVSVSST
R43	IHGGSGGRGVSVSST
S46	GSGGrGVSVSSTrFV
S49	GrGVSVSSTrFVTSS
R51-m1	GVSVSSTrFVTSSSG
T54	VSSTrFVTSSSGsyG
S55	SSTrFVTSSSGsyGG
S59-p	FVTSSSGsyGGVrGG
Y60-p	VTSSSGsyGGVrGGs
R64	SGsyGGVRGGsFSGT
R64-m1	SGsyGGVrGGsFSGT
S67-p	yGGVrGGsFSGTLAV
F68	GGVrGGsFSGTLAVs
S75-p	FSGTLAVsDGLLSGN
K84	GLLSGNEKITMQNLN
S96	NLNDRLASYLDKVRA
Y97	LNDRLASYLDKVRAL
K100	RLASYLDKVRALEQA
K114	ANGELEVKIRDWYQK
Y119	EVKIRDWYQKQGPGP
K121	KIRDWYQKQGPGPSR
Y133	PSRDYNHYFKTIEDL
F134	SRDYNHYFKTIEDLR
K143	TIEDLRDKILGATID
T148	RDKILGATIDNSKIV
K171-u	AADDFRTkFETEHAL
K211	EMQIESLKEELAYLK
K211	EMQIESLKEELAYLK
Y216	SLKEELAYLKkNHEE
K218	KEELAYLKkNHEEEI
K219-u	EELAYLKkNHEEEIT
K250	TPGVDLAKILSEMRS
Y259	LSEMRSQYEIMAEKN
K268	IMAEKNRKDAEATYL
A276	DAEATYLARIEELNT
I278	EATYLARIEELNTQV
S315	GLEIELQSQLSMKAA
K320	LQSQLSMKAALEGTL
K373	YKQLMDIKSRLEQEI
R375	QLMDIKSRLEQEIAT
Y383	LEQEIATYRSLLEGQ
Y394-p	LEGQEAHyNNLPtPK
N396	GQEAHyNNLPtPKAI
P398	EAHyNNLPtPKAI__
T399-p	AHyNNLPtPKAI___
K401	yNNLPtPKAI_____

	rat
R7	_MTSYSYRQsSAMsS
R7	_MTSYSYRQsSAMsS
S9-p	TSYSYRQsSAMsSYG
S10	SYSYRQsSAMsSYGG
M12	SYRQsSAMsSYGGMG
S13-p	YRQsSAMsSYGGMGG
S14	RQsSAMsSYGGMGGG
P22	YGGMGGGPVrFGSGG
R24-m1	GMGGGPVrFGSGGVF
R24	GMGGGPVRFGSGGVF
S27	GGPVrFGSGGVFrAP
R32-m1	FGSGGVFrAPSIHGG
S35	GGVFrAPSIHGGSGG
S40	APSIHGGSGGrGVSV
R43-m1	IHGGSGGrGVSVSST
R43	IHGGSGGRGVSVSST
S46	GSGGrGVSVSSTrIV
S49	GrGVSVSSTrIVssS
R51-m1	GVSVSSTrIVssSSG
S54-p	VSSTrIVssSSGGYV
S55-p	SSTrIVssSSGGYVG
-	gap
Y60	VssSSGGYVGGrGGs
R64	SGGYVGGRGGsFSGA
R64-m1	SGGYVGGrGGsFSGA
S67-p	YVGGrGGsFSGALTV
F68	VGGrGGsFSGALTVT
T75	FSGALTVTDGLLGGN
K84	GLLGGNEKITMQNLN
S96	NLNDRLASyLDKVRA
Y97-p	LNDRLASyLDKVRAL
K100	RLASyLDKVRALEQA
K114	ANGELEVKIRDWYQK
Y119	EVKIRDWYQKQGPGP
K121	KIRDWYQKQGPGPFR
Y133	PFRDYSQYFKTIEDL
F134	FRDYSQYFKTIEDLR
K143	TIEDLRDKILGATIE
T148	RDKILGATIENSKIV
K171	AADDFRTKFETEQAL
K211	EMQIENLKEELAYLK
K211	EMQIENLKEELAYLK
Y216	NLKEELAYLKKNHEE
K218	KEELAYLKKNHEEEI
K219	EELAYLKKNHEEEIS
K250	TPGIDLAKILSEMRS
Y259	LSEMRSQYEAMAEKN
K268	AMAEKNRKDAEAWYL
T276	DAEAWYLTQIDELNT
I278	EAWYLTQIDELNTQV
S315	DLEIELQSQLSMKAA
K320	LQSQLSMKAALEGTV
K373	YQQLMDIKSrLEQEI
R375-m1	QLMDIKSrLEQEIAT
Y383	LEQEIATYRSLLEGQ
Y394	LEGQEAHYNsLSIAK
S396-p	GQEAHYNsLSIAKAL
S398	EAHYNsLSIAKAL__
I399	AHYNsLSIAKAL___
K401	YNsLSIAKAL_____

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