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Protein Page:
F2RL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
F2RL1 a G-protein coupled receptor for trypsin and trypsin-like enzymes. Acts as a sensor for proteolytic enzymes generated during infection. Modulates pro-inflammatory responses, and innate and adaptive immunity. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. Activates several signaling molecules including phospholipase C (PLC), mitogen-activated protein kinase (MAPK), IKK/NFkB and Rho. Elevates intracellular calcium. Can also be transactivated by cleaved PAR1. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha- 12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, may signal through G(i) subunit alpha. Believed to be a class B receptor that internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram- positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders. Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral
Cellular Component: Golgi apparatus; integral to plasma membrane; plasma membrane; pseudopodium
Molecular Function: G-protein coupled receptor activity; protein binding; G-protein alpha-subunit binding; G-protein beta-subunit binding; receptor activity; thrombin receptor activity; receptor binding
Biological Process: negative regulation of JNK cascade; positive regulation of positive chemotaxis; positive regulation of cytokine secretion during immune response; positive regulation of JNK cascade; positive regulation of leukocyte chemotaxis; positive regulation of vasodilation; regulation of JNK cascade; negative regulation of toll-like receptor 3 signaling pathway; T cell activation during immune response; elevation of cytosolic calcium ion concentration; positive regulation of glomerular filtration; positive regulation of superoxide release; interleukin-1 beta secretion; inflammatory response; regulation of I-kappaB kinase/NF-kappaB cascade; defense response to virus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of actin filament depolymerization; neutrophil activation; positive regulation of chemotaxis; positive regulation of eosinophil degranulation; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of Rho protein signal transduction; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; G-protein coupled receptor protein signaling pathway; positive regulation of pseudopodium formation; regulation of blood coagulation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; positive regulation of phagocytosis, engulfment; leukocyte migration; positive regulation of cell migration
Reference #:  P55085 (UniProtKB)
Alt. Names/Synonyms: coagulation factor II (thrombin) receptor-like 1; Coagulation factor II receptor-like 1; F2RL1; G protein-coupled receptor-11; G-protein coupled receptor 11; GPR11; PAR-2; PAR2; protease-activated receptor 2; Proteinase-activated receptor 2; proteinase-activated receptor-2; Thrombin receptor-like 1
Gene Symbols: F2RL1
Molecular weight: 44,126 Da
Basal Isoelectric point: 9.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

F2RL1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K41-ub KGRSLIGkVDGtsHV
0 1 T45-ga LIGkVDGtsHVtGKG
0 1 S46-ga IGkVDGtsHVtGKGV
0 1 T49-ga VDGtsHVtGKGVtVE
0 1 T54-ga HVtGKGVtVETVFSV
0 1 R362 AKNALLCRSVRTVkQ
0 2 K368-ub CRSVRTVkQMQVsLT
0 1 S373-p TVkQMQVsLTskKHs
0 1 S376-p QMQVsLTskKHsRKs
0 1 K377-ub MQVsLTskKHsRKss
0 1 S380-p sLTskKHsRKsssys
0 1 S383-p skKHsRKsssyssss
0 5 S384-p kKHsRKsssysssst
0 1 S385-p KHsRKsssysssstT
0 29 Y386-p HsRKsssysssstTV
0 2 S387-p sRKsssysssstTVk
0 3 S388-p RKsssysssstTVkT
0 1 S389-p KsssysssstTVkTS
0 1 S390-p sssysssstTVkTSy
0 1 T391-p ssysssstTVkTSy_
0 2 K394-ub sssstTVkTSy____
0 1 Y397-p stTVkTSy_______
  mouse

 
R43 KGRSLIGRLETQPPI
- gap
- gap
T51 LETQPPITGKGVPVE
P56 PITGKGVPVEPGFSI
R364-m2 ARNALLCrSVRTVNR
N370 CrSVRTVNRMQISLS
S375 TVNRMQISLSSNKFS
S378 RMQISLSSNKFSRKS
N379 MQISLSSNKFSRKSG
S382 SLSSNKFSRKSGSYS
S385 SNKFSRKSGSYSSSS
G386 NKFSRKSGSYSSSST
S387 KFSRKSGSYSSSSTS
Y388 FSRKSGSYSSSSTSV
S389 SRKSGSYSSSSTSVk
S390 RKSGSYSSSSTSVkT
S391 KSGSYSSSSTSVkTS
S392 SGSYSSSSTSVkTSY
T393 GSYSSSSTSVkTSY_
K396-ub SSSSTSVkTSY____
Y399 STSVkTSY_______
  rat

 
R41 KGRSLIGRLDTPPPI
- gap
- gap
T49 LDTPPPITGKGAPVE
P54 PITGKGAPVEPGFSV
R362 ARNALLCRSVRTVKR
K368 CRSVRTVKRMQISLT
S373 TVKRMQISLTSNKFS
S376 RMQISLTSNKFSRKS
N377 MQISLTSNKFSRKSS
S380 SLTSNKFSRKSSSYS
S383 SNKFSRKSSSYSSSS
S384 NKFSRKSSSYSSSST
S385 KFSRKSSSYSSSSTS
Y386 FSRKSSSYSSSSTSV
S387 SRKSSSYSSSSTSVK
S388 RKSSSYSSSSTSVKT
S389 KSSSYSSSSTSVKTS
S390 SSSYSSSSTSVKTSY
T391 SSYSSSSTSVKTSY_
K394 SSSSTSVKTSY____
Y397 STSVKTSY_______
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