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Protein Page:
RASA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RASA1 a GTPase activator for normal RAS p21 but not its oncogenic counterpart, converting it to the putatively inactive GDP-bound state. Acting as a suppressor of RAS function, it enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: GAPs, Ras; GAPs; Motility/polarity/chemotaxis
Cellular Component: ruffle; cytoplasm; cytosol
Molecular Function: protein binding; GTPase binding; glycoprotein binding; potassium channel inhibitor activity; Ras GTPase activator activity; receptor binding
Biological Process: regulation of cell shape; positive regulation of Ras GTPase activity; regulation of actin filament polymerization; embryonic development; cytokinesis after mitosis; regulation of RNA metabolic process; negative regulation of Ras protein signal transduction; negative regulation of cell adhesion; negative regulation of neuron apoptosis; signal transduction; vasculogenesis; negative regulation of cell-matrix adhesion
Reference #:  P20936 (UniProtKB)
Alt. Names/Synonyms: CM-AVM; CMAVM; DKFZp434N071; GAP; GTPase-activating protein; p120GAP; p120RASGAP; PKWS; Ras GTPase-activating protein 1; Ras p21 protein activator; RAS p21 protein activator (GTPase activating protein) 1; RASA; RASA1; RasGAP; triphosphatase-activating protein
Gene Symbols: RASA1
Molecular weight: 116,403 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  T Cell Receptor Signaling
Select Structure to View Below

RASA1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y164-p DSLDGPEyEEEEVAI
0 4 Y239-p IIAMCGDyYIGGRRF
0 1 K292 RAILPYTKVPDTDEI
0 1 S418 MGGRYYNSIGDIIDH
0 1 T453-p QEQVLNDtVDGKEIy
2 31 Y460-p tVDGKEIyNtIRRKT
0 11 T462-p DGKEIyNtIRRKTKD
0 4 Y472-p RKTKDAFyKNIVKKG
0 1 N577 KGLQAFCNLRKSSPG
0 3 S582 FCNLRKSSPGTSNKR
0 3 T585 LRKSSPGTSNKRLRQ
0 2 T612-p KLPVKHFtNPyCNIY
0 74 Y615-p VKHFtNPyCNIYLNS
0 1 Y723 KIMPEEEYSEFKELI
0 1 S724 IMPEEEYSEFKELIL
0 1 S754-p QDRTLLAsILLRIFL
0 2 S831-p SKQSCELsPSKLEKN
0 5 Y952-p EFGAKEPyMEGVNPF
  mouse

 
Y155-p DSLDGPEyEEEEVAI
Y230 IIAMCGDYYIGGRRF
K283-ub RAILPYTkVPDTDEI
S409-p MGGRYYNsIGDIIDH
T444 QGQVLNDTVDGKEIy
Y451-p TVDGKEIyNTIRRKT
T453 DGKEIyNTIRRKTKD
Y463-p RKTKDAFyKNIVKKG
S568-p KGLQAFCsLRKSsPG
S573-p FCsLRKSsPGtSNKR
T576-p LRKSsPGtSNKRLRQ
T603 KLPVKHFTNPyCNIY
Y606-p VKHFTNPyCNIYLNS
Y714-p KIMPEEEysEFKELI
S715-p IMPEEEysEFKELIL
S745 QDRTLLASILLKIFL
S822 SKQSCELSPSKLEKN
Y943-p EFGAKEPyMEGVNPF
  rat

 
Y155 DSLDGPEYEEEEVAI
Y230 IIAMCGDYYIGGRRF
K283 RAILPYTKVPDTDEI
S409 MGGRYYNSIGDIIDH
T444 QGQVLNDTVDGKEIy
Y451-p TVDGKEIyNTIRRKT
T453 DGKEIyNTIRRKTKD
Y463 RKTKDAFYKNIVKKG
S568 KGLQAFCSLRKSSPG
S573 FCSLRKSSPGTSNKR
T576 LRKSSPGTSNKRLRQ
T603 KLPVKHFTNPYCNIY
Y606 VKHFTNPYCNIYLNS
Y714 KIMPEEEYSEFKELI
S715 IMPEEEYSEFKELIL
S745 QDRTLLASILLKIFL
S822 SKQSCELSPSKLEKN
Y943 EFGAKEPYMEGVNPF
  cow

 
Y161 DSLDGPEYEEEEVAI
Y236 IIAMCGDYYIGGRRF
K289 RAILPYTKVPDTDEI
S415 MGGRYYNSIGDIIDH
A450 QEQVLNDAVDGKEIy
Y457-p AVDGKEIyNTIRRKT
T459 DGKEIyNTIRRKTKD
Y469 RKTKDAFYKNIVKKG
N574 KGLQAFCNLRKSSPG
S579 FCNLRKSSPGTSNKR
T582 LRKSSPGTSNKRLRQ
T609 KLPVKHFTNPYCNIY
Y612 VKHFTNPYCNIYLNS
Y720 KIMPEEEYSEFKELI
S721 IMPEEEYSEFKELIL
S751 QDRTLLASILLKIFL
S828 SKQSCELSPSKLEKN
Y949 EFGAKEPYMEGVNPF
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