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RASA1
a GTPase activator for normal RAS p21 but not its oncogenic counterpart, converting it to the putatively inactive GDP-bound state. Acting as a suppressor of RAS function, it enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: GTPase activating protein, Ras; Motility/polarity/chemotaxis |
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Cellular Component: ruffle; cytoplasm; cytosol
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Molecular Function: GTPase binding; protein binding; phospholipid binding; glycoprotein binding; potassium channel inhibitor activity; Ras GTPase activator activity; receptor binding
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Biological Process: regulation of cell shape; regulation of actin filament polymerization; embryonic development; positive regulation of Ras GTPase activity; regulation of RNA metabolic process; negative regulation of Ras protein signal transduction; cytokinesis; negative regulation of cell adhesion; negative regulation of neuron apoptosis; negative regulation of cell-matrix adhesion; signal transduction; vasculogenesis
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Reference #:
P20936 (UniProtKB)
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| Alt. Names/Synonyms: CM-AVM; CMAVM; DKFZp434N071; GAP; GTPase-activating protein; p120GAP; p120RASGAP; PKWS; Ras GTPase-activating protein 1; Ras p21 protein activator; RAS p21 protein activator (GTPase activating protein) 1; RASA; RASA1; RasGAP; triphosphatase-activating protein |
| Gene Symbols: RASA1 |
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Molecular weight: 116,403 Da
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Basal Isoelectric point: 6.11
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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GPCRs Signaling to MAPK/Erk
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Jak/Stat/IL-6 Signaling
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T Cell Receptor Signaling
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