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Protein Page:
GPR56 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GPR56 Could be involved in cell-cell interactions. Defects in GPR56 are the cause of bilateral frontoparietal polymicrogyria (BFPP). BFPP is characterized by disorganized cortical lamination that is most severe in frontal cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Cell adhesion; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16q13
Cellular Component: integral to plasma membrane; integral to membrane
Molecular Function: G-protein coupled receptor activity; collagen binding; extracellular matrix binding
Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; positive regulation of cell adhesion; cell-cell signaling; neuropeptide signaling pathway; cerebral cortex radial glia guided migration; positive regulation of Rho protein signal transduction; angiogenesis; brain development; cell adhesion; Rho protein signal transduction; layer formation in the cerebral cortex
Reference #:  Q9Y653 (UniProtKB)
Alt. Names/Synonyms: 7-transmembrane protein with no EGF-like N-terminal domains-1; BFPP; DKFZp781L1398; EGF-TM7-like; G protein-coupled receptor 56; G-protein coupled receptor 56; GPR56; Protein TM7XN1; TM7LN4; TM7XN1
Gene Symbols: GPR56
Molecular weight: 77,738 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
Select Structure to View Below

GPR56

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T51-ga SSLHYKPtPDLRISI
0 1 A169 HSPPHTAAHNASVDM
0 1 S173 HTAAHNASVDMCELK
0 1 T343-p QLQPKNVtLQCVFWV
0 1 S670-p LQARGGPsPLkSNsD
0 1 K673-ub RGGPsPLkSNsDsAR
0 1 S676-p PsPLkSNsDsARLPI
0 2 S678-p PLkSNsDsARLPIss
0 2 R680 kSNsDsARLPIssGs
0 1 S684-p DsARLPIssGsTSsS
0 1 S685-p sARLPIssGsTSsSR
0 3 S687-p RLPIssGsTSsSRI_
0 3 S690-p IssGsTSsSRI____
  mouse

 
S51 STLHYDQSSEPHIFV
S169-p HNAPHKVsHNAsVDM
S173-p HKVsHNAsVDMCDLK
T343 QPQPKNVTLQCVFWV
S664 FQAQGGPSPLKNNsD
K667 QGGPSPLKNNsDsAk
S670-p PSPLKNNsDsAkLPI
S672-p PLKNNsDsAkLPISs
K674-ub KNNsDsAkLPISsGs
S678 DsAkLPISsGsTSsS
S679-p sAkLPISsGsTSsSR
S681-p kLPISsGsTSsSRI_
S684-p ISsGsTSsSRI____
  rat

 
T51 STLHYDQTSEPHIFV
S169 HNAPHKVSHNASVNM
S173 HKVSHNASVNMCDLK
T343 QPQPKNVTLQCVFWV
S664 FQAQGGPSPLKNNSD
K667 QGGPSPLKNNSDSAK
S670 PSPLKNNSDSAKLPI
S672 PLKNNSDSAKLPISS
K674 KNNSDSAKLPISSGs
S678 DSAKLPISSGsTSSS
S679 SAKLPISSGsTSSSR
S681-p KLPISSGsTSSSRI_
S684 ISSGsTSSSRI____
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