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Protein Page:
PDXP (human)

Overview
PDXP Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. Homodimer. Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. Inhibited by NaF, Zn(2+), Ca(2+), Mn(2+) and EDTA. Belongs to the HAD-like hydrolase superfamily. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.74; Protein phosphatase, Ser/Thr (non-receptor); Cell cycle regulation; EC 3.1.3.3; Cofactor and Vitamin Metabolism - vitamin B6
Cellular Component: lamellipodium; plasma membrane; midbody; cytosol; cleavage furrow; actin cytoskeleton
Molecular Function: protein binding; phosphoserine phosphatase activity; heat shock protein binding; magnesium ion binding; phosphoprotein phosphatase activity; pyridoxal phosphatase activity
Biological Process: actin rod formation; positive regulation of actin filament depolymerization; regulation of mitosis; pyridoxal phosphate catabolic process; protein amino acid dephosphorylation; regulation of cytokinesis
Reference #:  Q96GD0 (UniProtKB)
Alt. Names/Synonyms: chronophin; CIN; dJ37E16.5; FLJ32703; PDXP; PLP; PLP phosphatase; PLPP; pyridoxal (pyridoxine, vitamin B6) phosphatase; pyridoxal phosphatase; Pyridoxal phosphate phosphatase
Gene Symbols: PDXP
Molecular weight: 31,698 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PDXP

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S58 GKAALFVSNNSRRAR
0 1 S61 ALFVSNNSRRARPEL
0 1 S185 RDPWHPLSDGSRTPG
0 1 T190 PLSDGSRTPGTGSLA
0 1 T193 DGSRTPGTGSLAAAV
0 1 T202-p SLAAAVEtASGRQAL
  mouse

 
S58-p GKNTLFVsNNsRRAR
S61-p TLFVsNNsRRARPEL
S181-p RDPWHPLsDGSRtPG
T186-p PLsDGSRtPGtGSLA
T189-p DGSRtPGtGSLAAAV
T198 SLAAAVETASGRQAL
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