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PDXP (human)

Overview PDXP Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. Homodimer. Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. Inhibited by NaF, Zn(2+), Ca(2+), Mn(2+) and EDTA. Belongs to the HAD-like hydrolase superfamily. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation; EC 3.1.3.74; Protein phosphatase, Ser/Thr (non-receptor); Cofactor and Vitamin Metabolism - vitamin B6; EC 3.1.3.3 Cellular Component: lamellipodium; plasma membrane; midbody; cytosol; actin cytoskeleton; cleavage furrow Molecular Function: protein binding; phosphoserine phosphatase activity; metal ion binding; heat shock protein binding; phosphoprotein phosphatase activity; pyridoxal phosphatase activity Biological Process: actin rod formation; positive regulation of actin filament depolymerization; regulation of mitosis; protein amino acid dephosphorylation; regulation of cytokinesis Reference #:  Q96GD0 (UniProtKB) Alt. Names/Synonyms: chronophin; CIN; dJ37E16.5; FLJ32703; PDXP; PLP; PLP phosphatase; PLPP; pyridoxal (pyridoxine, vitamin B6) phosphatase; pyridoxal phosphatase; Pyridoxal phosphate phosphatase Gene Symbols: PDXP Molecular weight: 31,698 Da Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states CST Pathways:  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PDXP 2CFR - A=1-296 (human) 2CFS - A=1-296 (human) 2CFT - A=1-296 (human) 2OYC - A=2-296 (human) 2P27 - A=2-296 (human) 2P69 - A=2-296 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 2CFR 2CFS 2CFT 2OYC 2P27 2P69  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S61	ALFVSNNSRRARPEL
0	1		S58	GKAALFVSNNSRRAR
0	1		S185	RDPWHPLSDGSRTPG
0	1		T190	PLSDGSRTPGTGSLA
0	1		T193	DGSRTPGTGSLAAAV
0	1		T202-p	SLAAAVEtASGRQAL

	mouse
S61-p	TLFVsNNsRRARPEL
S58-p	GKNTLFVsNNsRRAR
S181-p	RDPWHPLsDGSRtPG
T186-p	PLsDGSRtPGtGSLA
T189-p	DGSRtPGtGSLAAAV
T198	SLAAAVETASGRQAL

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