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Protein Page:
PLCZ1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PLCZ1 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase
Cellular Component: perinuclear region of cytoplasm; nucleus; cytosol
Molecular Function: signal transducer activity; calcium ion binding; phosphoinositide phospholipase C activity
Biological Process: inositol phosphate metabolic process; calcium ion transport; multicellular organismal development; egg activation; lipid catabolic process
Reference #:  Q86YW0 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1; MGC149685; NYD-SP27; Phosphoinositide phospholipase C-zeta-1; phospholipase C, zeta 1; Phospholipase C-zeta-1; PI-phospholipase C zeta 1; PLC-zeta-1; PLCZ1; PLCzeta; Testis-development protein NYD-SP27; testis-development related NYD-SP27
Gene Symbols: PLCZ1
Molecular weight: 70,411 Da
Basal Isoelectric point: 9.14  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below

PLCZ1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K344 KKKTRKLKIALALSD
0 1 K357 SDLVIYTKAEKFKSF
0 1 Y457 LDNGGSGYILKPHFL
  mouse

 
K381-ac KKRKRKMkIAMALSD
K394-ac SDLVIYTkAEKFRNF
Y494 LDNGGSGYILKPDIL
  rat

 
R380 KKKIRKLRVALALSD
K393 SDLVIYTKAEKFRNF
Y493-p LDNGGSGyVLKPDFL
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