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Protein Page:
PLCZ1 (human)

Overview
PLCZ1 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Phospholipase; Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11
Cellular Component: perinuclear region of cytoplasm; cytosol; nucleus
Molecular Function: signal transducer activity; calcium ion binding; phosphoinositide phospholipase C activity
Biological Process: inositol phosphate metabolic process; calcium ion transport; multicellular organismal development; egg activation; lipid catabolic process
Reference #:  Q86YW0 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1; MGC149685; NYD-SP27; Phosphoinositide phospholipase C-zeta-1; phospholipase C, zeta 1; Phospholipase C-zeta-1; PI-phospholipase C zeta 1; PLC-zeta-1; PLCZ1; PLCzeta; Testis-development protein NYD-SP27; testis-development related NYD-SP27
Gene Symbols: PLCZ1
Molecular weight: 70,411 Da
Basal Isoelectric point: 9.14  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below

PLCZ1

Protein Structure Not Found.


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