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Protein Page:
GPR50 (human)

Overview
GPR50 an orphan G protein coupled receptor with high sequence homology to the melatonin receptors MT1 and MT2. Does not bind melatonin. Forms heterodimers with MT1 and MT2 and acts as a negative regulator of MT1 agonist binding and G protein coupling; inhibition of melatonin receptor activity is dependent on the long, proline-rich carboxy terminal tail of GPR50. On a physiological level, GPR50 is involved in the regulation of adaptive thermoregulation in mammals and deletion of GPR50 in mice produces a profound effect on the response to fasting and facilitates entry into torpor. Polymorphisms in the corresponding GPR50 gene are associated with bipolar affective disorder and major depressive disorder in women, indicating that variation in GPR50 may be an important gender-specific risk factor for certain mental disorders. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: integral to plasma membrane
Molecular Function: G-protein coupled receptor activity; identical protein binding; protein binding; melatonin receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling
Reference #:  Q13585 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor 50; GPR50; H9; Mel1c; Melatonin-related receptor; MGC125342; MTR1L
Gene Symbols: GPR50
Molecular weight: 67,369 Da
Basal Isoelectric point: 7.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GPR50

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T361 ACPAVEETPMNVRNV
0 1 S415-p FSHSKAAsGHLKPVS
0 1 S425-p LKPVSGHsKPAsGHP
0 1 S429-p SGHsKPAsGHPKSAT
0 1 Y438-p HPKSATVyPKPASVH
  mouse

 
T369-p ACVAVEGtPRNVRNV
S423 SGHPKSASVYPKPAS
- gap
- gap
H433 PKPASSVHCKPASVH
  rat

 
T369 ACVAVAGTPRNVRNV
S423 SGHPKSASVYPRPAS
- gap
- gap
H433 PRPASSVHCKPASVH
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