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Protein Page:
PKM2 iso2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PKM2 iso2 one of three rate-limiting enzymes in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule ATP and a pyruvate molecule, which is a central metabolic intermediate that can be used as a building block or oxidized further. Overexpressed in a variety of cancers. Interacts with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. Binds Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogens is. There are several mammalian isozymes of pyruvate kinase encoded by different genes. The L type predominates in liver, and the M type in muscle and brain. Two alternatively spliced human isoforms of PKM2 have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.40; Kinase, other; Mitochondrial; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Nucleotide Metabolism - purine; Carbohydrate Metabolism - pyruvate
Chromosomal Location of Human Ortholog: 15q22
Cellular Component: mitochondrion; cytoplasm; plasma membrane; nucleus; cytosol; cilium
Molecular Function: potassium ion binding; protein binding; magnesium ion binding; pyruvate kinase activity; ATP binding
Biological Process: glycolysis; carbohydrate metabolic process; programmed cell death; glucose metabolic process; phosphorylation
Reference #:  P14618-2 (UniProtKB)
Alt. Names/Synonyms: CTHBP; Cytosolic thyroid hormone-binding protein; KPYM; MGC3932; OIP-3; OIP3; Opa-interacting protein 3; p58; PK, muscle type; PK2; PK3; PKM; PKM2; Pyruvate kinase 2/3; Pyruvate kinase isozymes M1/M2; Pyruvate kinase muscle isozyme; pyruvate kinase, muscle; TCB; THBP1; Thyroid hormone-binding protein 1; thyroid hormone-binding protein, cytosolic; Tumor M2-PK
Gene Symbols: PKM
Molecular weight: 58,062 Da
Basal Isoelectric point: 7.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PKM2 iso2

Protein Structure Not Found.


Wikipedia  |  Scansite  |  Pfam  |  ENZYME  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 39 K3-ac _____MSkPHSEAGT
0 2 K3-m3 _____MSkPHSEAGT
0 3 K3 _____MSKPHSEAGT
1 42 S37-p MCRLDIDsPPItARN
0 6 T41-p DIDsPPItARNtGII
1 3 T45-p PPItARNtGIICtIG
0 4 T50-p RNtGIICtIGPAsRs
0 2 S55-p ICtIGPAsRsVEtLk
0 4 S57-p tIGPAsRsVEtLkEM
0 1 T60-p PAsRsVEtLkEMIkS
0 3 K62-ac sRsVEtLkEMIkSGM
0 13 K62-ub sRsVEtLkEMIkSGM
0 1 K62-sc sRsVEtLkEMIkSGM
0 1 K66-ac EtLkEMIkSGMNVAR
0 10 K66-ub EtLkEMIkSGMNVAR
0 23 S77-p NVARLNFsHGtHEyH
0 1 T80-p RLNFsHGtHEyHAEt
0 1 - gap
1 234 Y83-p FsHGtHEyHAEtIkN
0 1 T87-p tHEyHAEtIkNVRtA
0 2 K89-ac EyHAEtIkNVRtAtE
0 15 K89-ub EyHAEtIkNVRtAtE
0 1 K89-sc EyHAEtIkNVRtAtE
0 2 T93-p EtIkNVRtAtEsFAs
0 3 T95-p IkNVRtAtEsFAsDP
0 4 S97-p NVRtAtEsFAsDPIL
0 31 S100-p tAtEsFAsDPILyRP
5 436 Y105-p FAsDPILyRPVAVAL
0 1 K115-ac VAVALDTkGPEIRTG
0 37 K115-ub VAVALDTkGPEIRTG
0 1 T121 TkGPEIRTGLIkGsG
0 3 K125-ub EIRTGLIkGsGtAEV
0 4 S127-p RTGLIkGsGtAEVEL
0 3 T129-p GLIkGsGtAEVELkk
0 39 K135-ac GtAEVELkkGATLkI
0 1 K135-sc GtAEVELkkGATLkI
0 20 K135-ub GtAEVELkkGATLkI
0 2 K136-ub tAEVELkkGATLkIt
0 1 K141-ac LkkGATLkItLDNAy
0 2 K141-ub LkkGATLkItLDNAy
0 2 T143-p kGATLkItLDNAyME
2 325 Y148-p kItLDNAyMEkCDEN
0 1 K151-ac LDNAyMEkCDENILW
0 32 K151-ub LDNAyMEkCDENILW
0 1 Y161-p ENILWLDykNICkVV
0 4 K162-ac NILWLDykNICkVVE
0 26 K162-ub NILWLDykNICkVVE
0 1 K166-ac LDykNICkVVEVGsK
0 99 K166-ub LDykNICkVVEVGsK
0 2 S172-p CkVVEVGsKIyVDDG
1 23 Y175-p VEVGsKIyVDDGLIs
0 1 S182-p yVDDGLIsLQVkQkG
0 2 K186-ac GLIsLQVkQkGADFL
0 1 K186-sc GLIsLQVkQkGADFL
0 4 K186-ub GLIsLQVkQkGADFL
0 1 K188-ac IsLQVkQkGADFLVt
0 3 K188-ub IsLQVkQkGADFLVt
0 1 F192 VkQkGADFLVtEVEN
0 2 T195-p kGADFLVtEVENGGs
0 3 S202-p tEVENGGsLGskkGV
0 1 S205-p ENGGsLGskkGVNLP
0 163 K206-ac NGGsLGskkGVNLPG
0 1 K206-sc NGGsLGskkGVNLPG
0 12 K206-ub NGGsLGskkGVNLPG
0 6 K207-ac GGsLGskkGVNLPGA
0 32 K207-ub GGsLGskkGVNLPGA
0 4 S222-p AVDLPAVsEkDIQDL
0 1 K224-ac DLPAVsEkDIQDLkF
0 1 K224-ub DLPAVsEkDIQDLkF
0 1 K224-sc DLPAVsEkDIQDLkF
0 3 K230-ac EkDIQDLkFGVEQDV
0 1 K230-ub EkDIQDLkFGVEQDV
0 6 S243-p DVDMVFAsFIRkAsD
0 1 K247-ub VFAsFIRkAsDVHEV
0 18 S249-p AsFIRkAsDVHEVRK
0 1 K261-ac VRKVLGEkGKNIkII
0 1 K261-sc VRKVLGEkGKNIkII
0 7 K261-ub VRKVLGEkGKNIkII
0 1 K266-ac GEkGKNIkIIskIEN
0 31 K266-ub GEkGKNIkIIskIEN
0 1 S269-p GKNIkIIskIENHEG
0 61 K270-ub KNIkIIskIENHEGV
0 1 S287-p FDEILEAsDGIMVAR
1 33 K305-ac GIEIPAEkVFLAQkM
0 22 K305-ub GIEIPAEkVFLAQkM
0 19 K311-ub EkVFLAQkMMIGRCN
0 16 K322-ub GRCNRAGkPVICAtQ
0 2 T328-p GkPVICAtQMLESMI
0 6 K336-ub QMLESMIkkPRPTRA
0 4 K337-ub MLESMIkkPRPTRAE
0 1 S346-p RPTRAEGsDVANAVL
0 1 D354 DVANAVLDGADCIML
0 2 S362-p GADCIMLsGEtAkGD
0 2 T365-p CIMLsGEtAkGDyPL
0 1 K367-ac MLsGEtAkGDyPLEA
0 2 K367-ub MLsGEtAkGDyPLEA
1 229 Y370-p GEtAkGDyPLEAVRM
2 126 Y390-p REAEAAIyHLQLFEE
0 1 T409-p APITSDPtEAtAVGA
0 1 T412-p TSDPtEAtAVGAVEA
0 1 S420-p AVGAVEAsFkCCsGA
0 4 K422-ac GAVEAsFkCCsGAII
0 1 S425-p EAsFkCCsGAIIVLT
0 4 K433-ub GAIIVLTkSGRSAHQ
1 2 K433-ac GAIIVLTkSGRSAHQ
0 1 - gap
0 1 - gap
0 2 S437 VLTkSGRSAHQVARY
1 2 T454-p RAPIIAVtRNPQTAR
0 5 Y466-p TARQAHLyRGIFPVL
0 1 K475-sc GIFPVLCkDPVQEAW
0 16 K475-ub GIFPVLCkDPVQEAW
0 1 K498-sc NFAMNVGkARGFFKk
0 3 K498-ac NFAMNVGkARGFFKk
0 3 K498-ub NFAMNVGkARGFFKk
0 1 K505-ub kARGFFKkGDVVIVL
0 1 S519 LTGWRPGSGFTNTMR
3827
  PKM2 iso2  
K3-ac _____MSkPHSEAGT
K3 _____MSKPHSEAGT
K3 _____MSKPHSEAGT
S37 MCRLDIDSPPITARN
T41 DIDSPPITARNTGII
T45 PPITARNTGIICTIG
T50 RNTGIICTIGPASRS
S55 ICTIGPASRSVETLK
S57 TIGPASRSVETLKEM
T60 PASRSVETLKEMIKS
K62 SRSVETLKEMIKSGM
K62 SRSVETLKEMIKSGM
K62 SRSVETLKEMIKSGM
K66 ETLKEMIKSGMNVAR
K66 ETLKEMIKSGMNVAR
S77 NVARLNFSHGTHEyH
T80 RLNFSHGTHEyHAET
- gap
Y83-p FSHGTHEyHAETIKN
T87 THEyHAETIKNVRTA
K89 EyHAETIKNVRTATE
K89 EyHAETIKNVRTATE
K89 EyHAETIKNVRTATE
T93 ETIKNVRTATESFAS
T95 IKNVRTATESFASDP
S97 NVRTATESFASDPIL
S100 TATESFASDPILyRP
Y105-p FASDPILyRPVAVAL
K115 VAVALDTKGPEIRTG
K115 VAVALDTKGPEIRTG
T121 TKGPEIRTGLIKGSG
K125 EIRTGLIKGSGTAEV
S127 RTGLIKGSGTAEVEL
T129 GLIKGSGTAEVELkK
K135-ac GTAEVELkKGATLKI
K135 GTAEVELKKGATLKI
K135 GTAEVELKKGATLKI
K136 TAEVELkKGATLKIT
K141 LkKGATLKITLDNAy
K141 LkKGATLKITLDNAy
T143 KGATLKITLDNAyME
Y148-p KITLDNAyMEKCDEN
K151 LDNAyMEKCDENILW
K151 LDNAyMEKCDENILW
Y161 ENILWLDYKNICKVV
K162 NILWLDYKNICKVVE
K162 NILWLDYKNICKVVE
K166 LDYKNICKVVEVGSK
K166 LDYKNICKVVEVGSK
S172 CKVVEVGSKIYVDDG
Y175 VEVGSKIYVDDGLIS
S182 YVDDGLISLQVKQKG
K186 GLISLQVKQKGADFL
K186 GLISLQVKQKGADFL
K186 GLISLQVKQKGADFL
K188 ISLQVKQKGADFLVT
K188 ISLQVKQKGADFLVT
F192 VKQKGADFLVTEVEN
T195 KGADFLVTEVENGGS
S202 TEVENGGSLGSkKGV
S205 ENGGSLGSkKGVNLP
K206-ac NGGSLGSkKGVNLPG
K206 NGGSLGSKKGVNLPG
K206 NGGSLGSKKGVNLPG
K207 GGSLGSkKGVNLPGA
K207 GGSLGSkKGVNLPGA
S222 AVDLPAVSEKDIQDL
K224 DLPAVSEKDIQDLKF
K224 DLPAVSEKDIQDLKF
K224 DLPAVSEKDIQDLKF
K230 EKDIQDLKFGVEQDV
K230 EKDIQDLKFGVEQDV
S243 DVDMVFASFIRKAsD
K247 VFASFIRKAsDVHEV
S249-p ASFIRKAsDVHEVRK
K261 VRKVLGEKGKNIKII
K261 VRKVLGEKGKNIKII
K261 VRKVLGEKGKNIKII
K266 GEKGKNIKIISKIEN
K266 GEKGKNIKIISKIEN
S269 GKNIKIISKIENHEG
K270 KNIKIISKIENHEGV
S287 FDEILEASDGIMVAR
K305-ac GIEIPAEkVFLAQKM
K305 GIEIPAEKVFLAQKM
K311 EkVFLAQKMMIGRCN
K322 GRCNRAGKPVICATQ
T328 GKPVICATQMLESMI
K336 QMLESMIKKPRPTRA
K337 MLESMIKKPRPTRAE
S346 RPTRAEGSDVANAVL
D354 DVANAVLDGADCIML
S362 GADCIMLSGETAKGD
T365 CIMLSGETAKGDyPL
K367 MLSGETAKGDyPLEA
K367 MLSGETAKGDyPLEA
Y370-p GETAKGDyPLEAVRM
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S405-p LVRASSHsTDLMEAM
Y421-p MGSVEASyKCLAAAL
S437 VLTESGRSAHQVARY
T454 RAPIIAVTRNPQTAR
Y466 TARQAHLYRGIFPVL
K475 GIFPVLCKDPVQEAW
K475 GIFPVLCKDPVQEAW
K498 NFAMNVGKARGFFKK
K498 NFAMNVGKARGFFKK
K498 NFAMNVGKARGFFKK
K505 KARGFFKKGDVVIVL
S519 LTGWRPGSGFTNTMR
3827
  PKM2 iso3  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S2-p ______MsPEAQPQR
Y68 LASSVPLYHAETIKN
T72 VPLYHAETIKNVRTA
K74 LYHAETIKNVRTATE
K74 LYHAETIKNVRTATE
K74 LYHAETIKNVRTATE
T78 ETIKNVRTATESFAS
T80 IKNVRTATESFASDP
S82 NVRTATESFASDPIL
S85 TATESFASDPILYRP
Y90 FASDPILYRPVAVAL
K100 VAVALDTKGPEIRTG
K100 VAVALDTKGPEIRTG
T106 TKGPEIRTGLIKGSG
K110 EIRTGLIKGSGTAEV
S112 RTGLIKGSGTAEVEL
T114 GLIKGSGTAEVELKK
K120 GTAEVELKKGATLKI
K120 GTAEVELKKGATLKI
K120 GTAEVELKKGATLKI
K121 TAEVELKKGATLKIT
K126 LKKGATLKITLDNAY
K126 LKKGATLKITLDNAY
T128 KGATLKITLDNAYME
Y133 KITLDNAYMEKCDEN
K136 LDNAYMEKCDENILW
K136 LDNAYMEKCDENILW
Y146 ENILWLDYKNICKVV
K147 NILWLDYKNICKVVE
K147 NILWLDYKNICKVVE
K151 LDYKNICKVVEVGSK
K151 LDYKNICKVVEVGSK
S157 CKVVEVGSKIYVDDG
Y160 VEVGSKIYVDDGLIS
S167 YVDDGLISLQVKQKG
K171 GLISLQVKQKGADFL
K171 GLISLQVKQKGADFL
K171 GLISLQVKQKGADFL
K173 ISLQVKQKGADFLVT
K173 ISLQVKQKGADFLVT
F177 VKQKGADFLVTEVEN
T180 KGADFLVTEVENGGS
S187 TEVENGGSLGSKKGV
S190 ENGGSLGSKKGVNLP
K191 NGGSLGSKKGVNLPG
K191 NGGSLGSKKGVNLPG
K191 NGGSLGSKKGVNLPG
K192 GGSLGSKKGVNLPGA
K192 GGSLGSKKGVNLPGA
S207 AVDLPAVSEKDIQDL
K209 DLPAVSEKDIQDLKF
K209 DLPAVSEKDIQDLKF
K209 DLPAVSEKDIQDLKF
K215 EKDIQDLKFGVEQDV
K215 EKDIQDLKFGVEQDV
S228 DVDMVFASFIRKASD
K232 VFASFIRKASDVHEV
S234 ASFIRKASDVHEVRK
K246 VRKVLGEKGKNIKII
K246 VRKVLGEKGKNIKII
K246 VRKVLGEKGKNIKII
K251 GEKGKNIKIISKIEN
K251 GEKGKNIKIISKIEN
S254 GKNIKIISKIENHEG
K255 KNIKIISKIENHEGV
S272 FDEILEASDGIMVAR
K290 GIEIPAEKVFLAQKM
K290 GIEIPAEKVFLAQKM
K296 EKVFLAQKMMIGRCN
K307 GRCNRAGKPVICATQ
T313 GKPVICATQMLESMI
K321 QMLESMIKKPRPTRA
K322 MLESMIKKPRPTRAE
S331 RPTRAEGSDVANAVL
D339 DVANAVLDGADCIML
S347 GADCIMLSGETAKGD
T350 CIMLSGETAKGDYPL
K352 MLSGETAKGDYPLEA
K352 MLSGETAKGDYPLEA
Y355 GETAKGDYPLEAVRM
Y375 REAEAAIYHLQLFEE
T394 APITSDPTEATAVGA
T397 TSDPTEATAVGAVEA
S405 AVGAVEASFKCCSGA
K407 GAVEASFKCCSGAII
S410 EASFKCCSGAIIVLT
K418 GAIIVLTKSGRSAHQ
K418 GAIIVLTKSGRSAHQ
- gap
- gap
S422 VLTKSGRSAHQVARY
T439 RAPIIAVTRNPQTAR
Y451 TARQAHLYRGIFPVL
K460 GIFPVLCKDPVQEAW
K460 GIFPVLCKDPVQEAW
K483 NFAMNVGKARGFFKK
K483 NFAMNVGKARGFFKK
K483 NFAMNVGKARGFFKK
K490 KARGFFKKGDVVIVL
S504 LTGWRPGSGFTNTMR
  mouse

 
K3 _____MPKPHSEAGT
K3 _____MPKPHSEAGT
K3-ub _____MPkPHSEAGT
S37-p MCRLDIDsAPItARN
T41-p DIDsAPItARNTGII
T45 APItARNTGIICTIG
T50 RNTGIICTIGPASRs
S55 ICTIGPASRsVEMLk
S57-p TIGPASRsVEMLkEM
M60 PASRsVEMLkEMIkS
K62 SRsVEMLKEMIkSGM
K62-ub SRsVEMLkEMIkSGM
K62 SRsVEMLKEMIkSGM
K66 EMLkEMIKSGMNVAR
K66-ub EMLkEMIkSGMNVAR
S77-p NVARLNFsHGTHEyH
T80 RLNFsHGTHEyHAET
- gap
Y83-p FsHGTHEyHAETIkN
T87 THEyHAETIkNVREA
K89 EyHAETIKNVREAtE
K89-ub EyHAETIkNVREAtE
K89 EyHAETIKNVREAtE
E93 ETIkNVREAtESFAs
T95-p IkNVREAtESFAsDP
S97 NVREAtESFAsDPIL
S100-p EAtESFAsDPILyRP
Y105-p FAsDPILyRPVAVAL
K115 VAVALDTKGPEIRTG
K115-ub VAVALDTkGPEIRTG
T121 TkGPEIRTGLIkGSG
K125-ub EIRTGLIkGSGTAEV
S127 RTGLIkGSGTAEVEL
T129 GLIkGSGTAEVELkK
K135-ac GTAEVELkKGATLkI
K135 GTAEVELKKGATLkI
K135-ub GTAEVELkKGATLkI
K136 TAEVELkKGATLkIT
K141 LkKGATLKITLDNAy
K141-ub LkKGATLkITLDNAy
T143 KGATLkITLDNAyME
Y148-p kITLDNAyMEkCDEN
K151 LDNAyMEKCDENILW
K151-ub LDNAyMEkCDENILW
Y161 ENILWLDYkNICkVV
K162 NILWLDYKNICkVVE
K162-ub NILWLDYkNICkVVE
K166 LDYkNICKVVEVGSK
K166-ub LDYkNICkVVEVGSK
S172 CkVVEVGSKIyVDDG
Y175-p VEVGSKIyVDDGLIS
S182 yVDDGLISLQVkEkG
K186 GLISLQVKEkGADFL
K186 GLISLQVKEkGADFL
K186-ub GLISLQVkEkGADFL
K188 ISLQVkEKGADFLVT
K188-ub ISLQVkEkGADFLVT
F192 VkEkGADFLVTEVEN
T195 kGADFLVTEVENGGs
S202-p TEVENGGsLGSkkGV
S205 ENGGsLGSkkGVNLP
K206-ac NGGsLGSkkGVNLPG
K206 NGGsLGSKkGVNLPG
K206-ub NGGsLGSkkGVNLPG
K207 GGsLGSkKGVNLPGA
K207-ub GGsLGSkkGVNLPGA
S222 AVDLPAVSEKDIQDL
K224 DLPAVSEKDIQDLKF
K224 DLPAVSEKDIQDLKF
K224 DLPAVSEKDIQDLKF
K230 EKDIQDLKFGVEQDV
K230 EKDIQDLKFGVEQDV
S243 DVDMVFASFIRKAAD
K247 VFASFIRKAADVHEV
A249 ASFIRKAADVHEVRK
K261 VRKVLGEKGKNIKII
K261 VRKVLGEKGKNIKII
K261 VRKVLGEKGKNIKII
K266 GEKGKNIKIISkIEN
K266 GEKGKNIKIISkIEN
S269 GKNIKIISkIENHEG
K270-ub KNIKIISkIENHEGV
S287 FDEILEASDGIMVAR
K305-ac GIEIPAEkVFLAQkM
K305-ub GIEIPAEkVFLAQkM
K311-ub EkVFLAQkMMIGRCN
K322 GRCNRAGKPVICAtQ
T328-p GKPVICAtQMLESMI
K336 QMLESMIKKPRPTRA
K337 MLESMIKKPRPTRAE
S346 RPTRAEGSDVANAVL
D354-ca DVANAVLdGADCIML
S362 GADCIMLSGETAKGD
T365 CIMLSGETAKGDyPL
K367 MLSGETAKGDyPLEA
K367 MLSGETAKGDyPLEA
Y370-p GETAKGDyPLEAVRM
Y390-p REAEAAIyHLQLFEE
T409 APITSDPTEAAAVGA
- gap
S420 AVGAVEASFKCCSGA
K422 GAVEASFKCCSGAII
S425 EASFKCCSGAIIVLT
K433 GAIIVLTKSGRsAHQ
K433 GAIIVLTKSGRsAHQ
- gap
- gap
S437-p VLTKSGRsAHQVARY
T454 RAPIIAVTRNPQTAR
Y466 TARQAHLYRGIFPVL
K475 GIFPVLCKDAVLNAW
K475-ub GIFPVLCkDAVLNAW
K498 NLAMDVGKARGFFKK
K498 NLAMDVGKARGFFKK
K498 NLAMDVGKARGFFKK
K505 KARGFFKKGDVVIVL
S519 LTGWRPGSGFTNTMR
3827
  rat

► Hide Isoforms
 
K3 _____MPKPDSEAGT
K3 _____MPKPDSEAGT
K3 _____MPKPDSEAGT
S37 MCRLDIDSAPItARN
T41-p DIDSAPItARNTGII
T45 APItARNTGIICTIG
T50 RNTGIICTIGPASRs
S55 ICTIGPASRsVEMLk
S57-p TIGPASRsVEMLkEM
M60 PASRsVEMLkEMIkS
K62-ac SRsVEMLkEMIkSGM
K62 SRsVEMLKEMIkSGM
K62 SRsVEMLKEMIkSGM
K66-ac EMLkEMIkSGMNVAR
K66 EMLkEMIKSGMNVAR
S77-p NVARLNFsHGTHEyH
T80 RLNFsHGTHEyHAET
- gap
Y83-p FsHGTHEyHAETIkN
T87 THEyHAETIkNVRAA
K89-ac EyHAETIkNVRAATE
K89 EyHAETIKNVRAATE
K89 EyHAETIKNVRAATE
A93 ETIkNVRAATEsFAs
T95 IkNVRAATEsFAsDP
S97-p NVRAATEsFAsDPIL
S100-p AATEsFAsDPILyRP
Y105-p FAsDPILyRPVAVAL
K115-ac VAVALDTkGPEIRtG
K115 VAVALDTKGPEIRtG
T121-p TkGPEIRtGLIKGsG
K125 EIRtGLIKGsGtAEV
S127-p RtGLIKGsGtAEVEL
T129-p GLIKGsGtAEVELkK
K135-ac GtAEVELkKGATLKI
K135 GtAEVELKKGATLKI
K135-ub GtAEVELkKGATLKI
K136 tAEVELkKGATLKIt
K141 LkKGATLKItLDNAy
K141 LkKGATLKItLDNAy
T143-p KGATLKItLDNAyME
Y148-p KItLDNAyMEKCDEN
K151 LDNAyMEKCDENILW
K151 LDNAyMEKCDENILW
Y161 ENILWLDYKNICkVV
K162 NILWLDYKNICkVVE
K162 NILWLDYKNICkVVE
K166-ac LDYKNICkVVEVGSK
K166-ub LDYKNICkVVEVGSK
S172 CkVVEVGSKIyVDDG
Y175-p VEVGSKIyVDDGLIS
S182 yVDDGLISLQVKEkG
K186 GLISLQVKEkGADyL
K186 GLISLQVKEkGADyL
K186 GLISLQVKEkGADyL
K188-ac ISLQVKEkGADyLVT
K188 ISLQVKEKGADyLVT
Y192-p VKEkGADyLVTEVEN
T195 kGADyLVTEVENGGs
S202-p TEVENGGsLGSkKGV
S205 ENGGsLGSkKGVNLP
K206-ac NGGsLGSkKGVNLPG
K206 NGGsLGSKKGVNLPG
K206 NGGsLGSKKGVNLPG
K207 GGsLGSkKGVNLPGA
K207 GGsLGSkKGVNLPGA
S222-p AVDLPAVsEkDIQDL
K224-ac DLPAVsEkDIQDLKF
K224 DLPAVsEKDIQDLKF
K224 DLPAVsEKDIQDLKF
K230 EkDIQDLKFGVEQDV
K230 EkDIQDLKFGVEQDV
S243 DVDMVFASFIRKAAD
K247 VFASFIRKAADVHEV
A249 ASFIRKAADVHEVRK
K261 VRKVLGEKGKNIkII
K261 VRKVLGEKGKNIkII
K261 VRKVLGEKGKNIkII
K266-ac GEKGKNIkIISKIEN
K266-ub GEKGKNIkIISKIEN
S269 GKNIkIISKIENHEG
K270 KNIkIISKIENHEGV
S287 FDEILEASDGIMVAR
K305-ac GIEIPAEkVFLAQKM
K305 GIEIPAEKVFLAQKM
K311 EkVFLAQKMMIGRCN
K322 GRCNRAGKPVICATQ
T328 GKPVICATQMLESMI
K336 QMLESMIKKPRPTRA
K337 MLESMIKKPRPTRAE
S346 RPTRAEGSDVANAVL
D354 DVANAVLDGADCIML
S362 GADCIMLSGETAKGD
T365 CIMLSGETAKGDyPL
K367 MLSGETAKGDyPLEA
K367 MLSGETAKGDyPLEA
Y370-p GETAKGDyPLEAVRM
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S405 LARASSQSTDPLEAM
Y421 MGSVEASYKCLAAAL
S437 VLTESGRSAHQVARY
T454 RAPIIAVTRNPQTAR
Y466 TARQAHLYRGIFPVL
K475 GIFPVLCKDAVLDAW
K475 GIFPVLCKDAVLDAW
K498 NLAMNVGKARGFFKK
K498 NLAMNVGKARGFFKK
K498 NLAMNVGKARGFFKK
K505 KARGFFKKGDVVIVL
S519-p LTGWRPGsGFTNTMR
3827
  PKM2 iso2  
K3 _____MPKPDSEAGT
K3 _____MPKPDSEAGT
K3 _____MPKPDSEAGT
S37 MCRLDIDSAPITARN
T41 DIDSAPITARNTGII
T45 APITARNTGIICTIG
T50 RNTGIICTIGPASRS
S55 ICTIGPASRSVEMLK
S57 TIGPASRSVEMLKEM
M60 PASRSVEMLKEMIKS
K62 SRSVEMLKEMIKSGM
K62 SRSVEMLKEMIKSGM
K62 SRSVEMLKEMIKSGM
K66 EMLKEMIKSGMNVAR
K66 EMLKEMIKSGMNVAR
S77 NVARLNFSHGTHEYH
T80 RLNFSHGTHEYHAET
- gap
Y83 FSHGTHEYHAETIKN
T87 THEYHAETIKNVRAA
K89 EYHAETIKNVRAATE
K89 EYHAETIKNVRAATE
K89 EYHAETIKNVRAATE
A93 ETIKNVRAATESFAS
T95 IKNVRAATESFASDP
S97 NVRAATESFASDPIL
S100 AATESFASDPILYRP
Y105 FASDPILYRPVAVAL
K115 VAVALDTKGPEIRTG
K115 VAVALDTKGPEIRTG
T121 TKGPEIRTGLIKGSG
K125 EIRTGLIKGSGTAEV
S127 RTGLIKGSGTAEVEL
T129 GLIKGSGTAEVELKK
K135 GTAEVELKKGATLKI
K135 GTAEVELKKGATLKI
K135 GTAEVELKKGATLKI
K136 TAEVELKKGATLKIT
K141 LKKGATLKITLDNAY
K141 LKKGATLKITLDNAY
T143 KGATLKITLDNAYME
Y148 KITLDNAYMEKCDEN
K151 LDNAYMEKCDENILW
K151 LDNAYMEKCDENILW
Y161 ENILWLDYKNICKVV
K162 NILWLDYKNICKVVE
K162 NILWLDYKNICKVVE
K166 LDYKNICKVVEVGSK
K166 LDYKNICKVVEVGSK
S172 CKVVEVGSKIYVDDG
Y175 VEVGSKIYVDDGLIS
S182 YVDDGLISLQVKEKG
K186 GLISLQVKEKGADYL
K186 GLISLQVKEKGADYL
K186 GLISLQVKEKGADYL
K188 ISLQVKEKGADYLVT
K188 ISLQVKEKGADYLVT
Y192 VKEKGADYLVTEVEN
T195 KGADYLVTEVENGGS
S202 TEVENGGSLGSKKGV
S205 ENGGSLGSKKGVNLP
K206 NGGSLGSKKGVNLPG
K206 NGGSLGSKKGVNLPG
K206 NGGSLGSKKGVNLPG
K207 GGSLGSKKGVNLPGA
K207 GGSLGSKKGVNLPGA
S222 AVDLPAVSEKDIQDL
K224 DLPAVSEKDIQDLKF
K224 DLPAVSEKDIQDLKF
K224 DLPAVSEKDIQDLKF
K230 EKDIQDLKFGVEQDV
K230 EKDIQDLKFGVEQDV
S243 DVDMVFASFIRKAAD
K247 VFASFIRKAADVHEV
A249 ASFIRKAADVHEVRK
K261 VRKVLGEKGKNIKII
K261 VRKVLGEKGKNIKII
K261 VRKVLGEKGKNIKII
K266 GEKGKNIKIISKIEN
K266 GEKGKNIKIISKIEN
S269 GKNIKIISKIENHEG
K270 KNIKIISKIENHEGV
S287 FDEILEASDGIMVAR
K305 GIEIPAEKVFLAQKM
K305 GIEIPAEKVFLAQKM
K311 EKVFLAQKMMIGRCN
K322 GRCNRAGKPVICATQ
T328 GKPVICATQMLESMI
K336 QMLESMIKKPRPTRA
K337 MLESMIKKPRPTRAE
S346 RPTRAEGSDVANAVL
D354 DVANAVLDGADCIML
S362 GADCIMLSGETAKGD
T365 CIMLSGETAKGDYPL
K367 MLSGETAKGDYPLEA
K367 MLSGETAKGDYPLEA
Y370 GETAKGDYPLEAVRM
Y390-p REAEAAIyHLQLFEE
T409 APITSDPTEAAAVGA
- gap
S420 AVGAVEASFKCCSGA
K422 GAVEASFKCCSGAII
S425 EASFKCCSGAIIVLT
K433 GAIIVLTKSGRSAHQ
K433 GAIIVLTKSGRSAHQ
- gap
- gap
S437 VLTKSGRSAHQVARY
T454 RAPIIAVTRNPQTAR
Y466 TARQAHLYRGIFPVL
K475 GIFPVLCKDAVLDAW
K475 GIFPVLCKDAVLDAW
K498 NLAMNVGKARGFFKK
K498 NLAMNVGKARGFFKK
K498 NLAMNVGKARGFFKK
K505 KARGFFKKGDVVIVL
S519 LTGWRPGSGFTNTMR
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