a transcriptional regulator of the histone deacetylase family, subfamily 1. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays a role in epigenetic repression and transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; EC 126.96.36.199; Transcription, coactivator/corepressor; Deacetylase
Molecular Function: deacetylase activity; NF-kappaB binding; protein binding; enzyme binding; nucleosomal DNA binding; NAD-dependent histone deacetylase activity (H3-K14 specific); sequence-specific DNA binding; heat shock protein binding; protein deacetylase activity; chromatin binding; histone deacetylase activity; transcription factor binding
Biological Process: response to nicotine; establishment and/or maintenance of chromatin architecture; nerve growth factor receptor signaling pathway; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; response to lipopolysaccharide; negative regulation of transcription from RNA polymerase II promoter; behavioral response to ethanol; regulation of gene expression, epigenetic; response to caffeine; positive regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of cell cycle; negative regulation of gene expression, epigenetic; positive regulation of cell proliferation; dendrite development; circadian regulation of gene expression; positive regulation of oligodendrocyte differentiation; response to drug; transcription, DNA-dependent; negative regulation of transcription factor activity; response to amphetamine; histone deacetylation; response to cocaine; positive regulation of tumor necrosis factor production; negative regulation of DNA binding; odontogenesis of dentine-containing teeth; chromatin remodeling; response to hyperoxia; ATP-dependent chromatin remodeling; maintenance of chromatin silencing; negative regulation of MHC class II biosynthetic process; epidermal cell differentiation; gene expression; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; blood coagulation; negative regulation of transcription, DNA-dependent; positive regulation of interleukin-1 production; negative regulation of apoptosis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.