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Protein Page:
HDAC2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HDAC2 a transcriptional regulator of the histone deacetylase family, subfamily 1. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays a role in epigenetic repression and transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Deacetylase; Nuclear receptor co-regulator; EC 3.5.1.98
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: nucleoplasm; heterochromatin; transcription factor complex; protein complex; Sin3 complex; ESC/E(Z) complex; nuclear chromatin; cytoplasm; replication fork; NuRD complex; nucleus
Molecular Function: deacetylase activity; protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); enzyme binding; nucleosomal DNA binding; NAD-dependent histone deacetylase activity (H3-K14 specific); sequence-specific DNA binding; heat shock protein binding; protein deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); chromatin binding; histone deacetylase activity; transcription factor binding; transcription factor activity
Biological Process: nerve growth factor receptor signaling pathway; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell cycle; cardiac muscle cell development; negative regulation of cardiac muscle cell proliferation; positive regulation of cell proliferation; dendrite development; circadian regulation of gene expression; positive regulation of oligodendrocyte differentiation; response to drug; transcription, DNA-dependent; negative regulation of transcription factor activity; hippocampus development; regulation of protein kinase B signaling cascade; histone deacetylation; response to cocaine; odontogenesis of dentine-containing teeth; chromatin remodeling; ATP-dependent chromatin remodeling; negative regulation of MHC class II biosynthetic process; maintenance of chromatin silencing; epidermal cell differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; blood coagulation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
Reference #:  Q92769 (UniProtKB)
Alt. Names/Synonyms: HD2; HDAC2; Histone deacetylase 2; RPD3; transcriptional regulator homolog RPD3; YAF1; YY1-associated factor 1
Gene Symbols: HDAC2
Molecular weight: 55,364 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
CST Pathways:  Crosstalk between PTMs  |  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HDAC2

Protein Structure Not Found.


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Sites Implicated In
acetylation: S394‑p, S411‑p, S422‑p, S424‑p
enzymatic activity, induced: S394‑p
enzymatic activity, inhibited: S394‑p, S411‑p, S422‑p, S424‑p
molecular association, regulation: S394‑p, S411‑p, S422‑p, S424‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S4 ____MAYSQGGGKKk
0 1 K11-ub SQGGGKKkVCYYYDG
0 1 T61-p IYRPHKAtAEEMTkY
0 2 K67-ub AtAEEMTkYHSDEYI
1 2 K75-ac YHSDEYIkFLRSIRP
0 3 K75-ub YHSDEYIkFLRSIRP
0 8 Y88-p RPDNMSEySkQMQRF
1 1 K90-ac DNMSEySkQMQRFNV
0 75 K90-ub DNMSEySkQMQRFNV
1 2 Y222-p IGAGKGKyYAVNFPM
0 15 K243-ub ESYGQIFkPIISkVM
0 1 K248-ub IFkPIISkVMEMYQP
0 1 S349 FKLHISPSNMTNQNt
0 1 T352 HISPSNMTNQNtPEy
0 2 T356-p SNMTNQNtPEyMEkI
0 2 Y359-p TNQNtPEyMEkIKQR
0 1 K362-ub NtPEyMEkIKQRLFE
5 102 S394-p EDAVHEDsGDEDGED
0 9 S407-p EDPDKRIsIRAsDKR
2 1 S411-p KRIsIRAsDKRIACD
3 78 S422-p IACDEEFsDsEDEGE
4 76 S424-p CDEEFsDsEDEGEGG
1 0 K462-sm EDKKTDVkEEDKSKD
0 1 T477-p NSGEKTDtKGTKSEQ
  mouse

 
S4-p ____MAYsQGGGKKK
K11 sQGGGKKKVCYYYDG
T61 IYRPHKATAEEMTKY
K67 ATAEEMTKYHSDEYI
K75-ac YHSDEYIkFLRSIRP
K75-ub YHSDEYIkFLRSIRP
Y88-p RPDNMSEySkQMQRF
K90 DNMSEySKQMQRFNV
K90-ub DNMSEySkQMQRFNV
Y222 IGAGKGKYYAVNFPM
K243-ub ESYGQIFkPIISKVM
K248 IFkPIISKVMEMYQP
S349-p FKLHISPsNMtNQNt
T352-p HISPsNMtNQNtPEy
T356-p sNMtNQNtPEyMEKI
Y359-p tNQNtPEyMEKIKQR
K362 NtPEyMEKIKQRLFE
S394-p EDAVHEDsGDEDGED
S407 EDPDKRISIRAsDKR
S411-p KRISIRAsDKRIACD
S422-p IACDEEFsDsEDEGE
S424-p CDEEFsDsEDEGEGG
K462 EDKKTDVKEEDKSKD
P477 NSGEKTDPKGAKSEQ
  rat

 
S4 ____MAYSQGGGKKK
K11 SQGGGKKKVCYYYDG
T61 IYRPHKATAEEMTKY
K67 ATAEEMTKYHSDEYI
K75 YHSDEYIKFLRSIRP
K75 YHSDEYIKFLRSIRP
Y88 RPDNMSEYSkQMQRF
K90-ac DNMSEYSkQMQRFNV
K90 DNMSEYSKQMQRFNV
Y222 IGAGKGKYYAVNFPM
K243 ESYGQIFKPIISKVM
K248 IFKPIISKVMEMYQP
S349 FKLHISPSNMTNQNT
T352 HISPSNMTNQNTPEY
T356 SNMTNQNTPEYMEKI
Y359 TNQNTPEYMEKIKQR
K362 NTPEYMEKIKQRLFE
S394-p EDAVHEDsGDEDGED
S407 EDPDKRISIRASDKR
S411 KRISIRASDKRIACD
S422-p IACDEEFsDsEDEGE
S424-p CDEEFsDsEDEGEGG
K462 EDKRTDVKEEDKSKD
T477 NSGEKTDTKGAKSEQ
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