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HDAC2 (human)

Overview HDAC2 a transcriptional regulator of the histone deacetylase family, subfamily 1. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays a role in epigenetic repression and transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Note: This description may include information from UniProtKB. Protein type: EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Deacetylase Cellular Component: nucleoplasm; heterochromatin; transcription factor complex; Sin3 complex; ESC/E(Z) complex; cytoplasm; replication fork; NuRD complex; nucleus Molecular Function: protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); enzyme binding; NAD-dependent histone deacetylase activity (H3-K14 specific); sequence-specific DNA binding; chromatin DNA binding; protein deacetylase activity; chromatin binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription factor binding; transcription factor activity Biological Process: transcription, DNA-dependent; nerve growth factor receptor signaling pathway; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; negative regulation of transcription factor activity; hippocampus development; positive regulation of collagen biosynthetic process; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter; odontogenesis of dentine-containing teeth; negative regulation of cell cycle; chromatin remodeling; positive regulation of cell proliferation; maintenance of chromatin silencing; dendrite development; negative regulation of MHC class II biosynthetic process; epidermal cell differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; positive regulation of oligodendrocyte differentiation; negative regulation of transcription, DNA-dependent; blood coagulation; negative regulation of apoptosis Reference #:  Q92769 (UniProtKB) Alt. Names/Synonyms: HD2; HDAC2; Histone deacetylase 2; RPD3; transcriptional regulator homolog RPD3; YAF1; YY1-associated factor 1 Gene Symbols: HDAC2 Molecular weight: 55,364 Da Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HDAC2 3MAX - A/C/B=9-374 (human)

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	Sites Implicated In
acetylation: S394‑p, S411‑p, S422‑p, S424‑p enzymatic activity, induced: S394‑p enzymatic activity, inhibited: S394‑p, S411‑p, S422‑p, S424‑p molecular association, regulation: S394‑p, S411‑p, S422‑p, S424‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y3-p	_____MAySQGGGKK
0	1		S4	____MAySQGGGKKk
0	1		K11-u	SQGGGKKkVCYYYDG
0	1		Y49-p	LLLNYGLyRKMEIYR
0	2		K67-u	ATAEEMTkYHSDEYI
0	1		K75-a	YHSDEYIkFLRSIRP
0	3		K75-u	YHSDEYIkFLRSIRP
0	8		Y88-p	RPDNMSEySkQMQRF
0	75		K90-u	DNMSEySkQMQRFNV
0	2		Y222-p	IGAGKGKyYAVNFPM
0	15		K243-u	ESYGQIFkPIISkVM
0	1		K248-u	IFkPIISkVMEMYQP
0	1		S349	FKLHISPSNMTNQNT
0	1		T352	HISPSNMTNQNTPEy
0	1		T356	SNMTNQNTPEyMEkI
0	2		Y359-p	TNQNTPEyMEkIKQR
0	1		K362-u	NTPEyMEkIKQRLFE
3	82		S394-p	EDAVHEDsGDEDGED
0	5		S407-p	EDPDKRIsIRAsDKR
2	0		S411-p	KRIsIRAsDKRIACD
2	60		S422-p	IACDEEFsDsEDEGE
3	59		S424-p	CDEEFsDsEDEGEGG
1	0		K462-s	EDKKTDVkEEDKSKD
0	1		T477-p	NSGEKTDtKGTKSEQ

	mouse
Y3	_____MAYsQGGGKK
S4-p	____MAYsQGGGKKK
K11	sQGGGKKKVCYYYDG
Y49	LLLNYGLYRKMEIYR
K67	ATAEEMTKYHSDEYI
K75	YHSDEYIKFLRSIRP
K75-u	YHSDEYIkFLRSIRP
Y88-p	RPDNMSEySkQMQRF
K90-u	DNMSEySkQMQRFNV
Y222	IGAGKGKYYAVNFPM
K243-u	ESYGQIFkPIISKVM
K248	IFkPIISKVMEMYQP
S349-p	FKLHISPsNMtNQNt
T352-p	HISPsNMtNQNtPEy
T356-p	sNMtNQNtPEyMEKI
Y359-p	tNQNtPEyMEKIKQR
K362	NtPEyMEKIKQRLFE
S394-p	EDAVHEDsGDEDGED
S407	EDPDKRISIRAsDKR
S411-p	KRISIRAsDKRIACD
S422-p	IACDEEFsDsEDEGE
S424-p	CDEEFsDsEDEGEGG
K462	EDKKTDVKEEDKSKD
P477	NSGEKTDPKGAKSEQ

	rat
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S35	FKLHISPSNMTNQNT
T38	HISPSNMTNQNTPEY
T42	SNMTNQNTPEYMEKI
Y45	TNQNTPEYMEKIKQR
K48	NTPEYMEKIKQRLFE
S80	EDAVHEDSGDEDGED
S93	EDPDKRISIRASDKR
S97	KRISIRASDKRIACD
S108-p	IACDEEFsDsEDEGE
S110-p	CDEEFsDsEDEGEGG
K148	EDKKTDVKEEDKSKD
T163	NSGEKTDTKGAKSEQ

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