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Smad8 (human)

Overview Smad8 transcription factor phosphorylated and activated by bone morphogenetic protein receptor kinases. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where they regulate transcription of target genes. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Two alternatively spliced products have been described. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription, coactivator/corepressor Cellular Component: nucleoplasm; transcription factor complex; intracellular; cytosol; nucleus Molecular Function: transcription factor activity; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Biological Process: BMP signaling pathway; Mullerian duct regression; transcription, DNA-dependent; ureteric bud development; positive regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; midbrain development; response to hypoxia; positive regulation of cell differentiation; protein amino acid phosphorylation; hindbrain development Reference #:  O15198 (UniProtKB) Alt. Names/Synonyms: MAD homolog 9; MADH6; MADH9; Mothers against decapentaplegic homolog 9; Mothers against decapentaplegic, drosophila, homolog of, 9; Mothers against DPP homolog 9; SMAD 9; SMAD family member 9; SMAD, mothers against DPP homolog 9; SMAD8; SMAD8A; SMAD8B; SMAD9 Gene Symbols: SMAD9 Molecular weight: 52,493 Da Basal Isoelectric point: 7.87  Predict pI for various phosphorylation states CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-ß Signaling

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STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 178600 603295  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S40-p	WAEKAVDsLVKKLKK
1	1		T136-p	YHYRRVEtPVLPPVL
0	1		K159-u	PQLSLLAkFRSASLH
2	64		S465-p	SPHNPISsVs_____
2	64		S467-p	HNPISsVs_______

	mouse
S40	WAEKAVDSLVKKLKK
T136-p	YHYRRVEtPVLPPVL
K159	PQLSLLAKFRSASLH
S428-p	SPHNPISsVs_____
S430-p	HNPISsVs_______

	rat
S40	WAEKAVDSLVKKLKK
T136	YHYRRVETPVLPPVL
K159	PQLSLLAKFRSASLH
S432	SPHNPISSVs_____
S434-p	HNPISSVs_______

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