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Protein Page:
Smad8 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Smad8 transcription factor phosphorylated and activated by bone morphogenetic protein receptor kinases. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where they regulate transcription of target genes. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Two alternatively spliced products have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; DNA binding protein
Cellular Component: nucleoplasm; transcription factor complex; intracellular; cytosol; nucleus
Molecular Function: protein binding; DNA binding; metal ion binding; transcription factor activity; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Biological Process: BMP signaling pathway; Mullerian duct regression; transcription, DNA-dependent; ureteric bud development; positive regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; cartilage development; midbrain development; response to hypoxia; positive regulation of cell differentiation; protein amino acid phosphorylation; hindbrain development
Reference #:  O15198 (UniProtKB)
Alt. Names/Synonyms: MAD homolog 9; MADH6; MADH9; Mothers against decapentaplegic homolog 9; Mothers against decapentaplegic, drosophila, homolog of, 9; Mothers against DPP homolog 9; SMAD 9; SMAD family member 9; SMAD, mothers against DPP homolog 9; SMAD8; SMAD8A; SMAD8B; SMAD9
Gene Symbols: SMAD9
Molecular weight: 52,493 Da
Basal Isoelectric point: 7.87  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-ß Signaling
Select Structure to View Below

Smad8

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S40-p WAEKAVDsLVKKLKK
1 2 T136-p YHYRRVEtPVLPPVL
0 1 K159-ub PQLSLLAkFRSASLH
0 7 S464-p GSPHNPIssVs____
2 65 S465-p SPHNPIssVs_____
2 67 S467-p HNPIssVs_______
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
  mouse

 
S40 WAEKAVDSLVKKLKK
T136-p YHYRRVEtPVLPPVL
K159 PQLSLLAKFRSASLH
S427-p GSPHNPIssVs____
S428-p SPHNPIssVs_____
S430-p HNPIssVs_______
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
  rat

 
S40 WAEKAVDSLVKKLKK
T136 YHYRRVETPVLPPVL
K159 PQLSLLAKFRSASLH
S431 GSPHNPISSVs____
S432 SPHNPISSVs_____
S434-p HNPISSVs_______
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
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