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HNF4 alpha
a nuclear transcription factor which binds DNA as a homodimer. Controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic gene, alpha 1-antitrypsin, apolipoprotein CIII, and transthyretin genes. May be essential for development of the liver, kidney and intestine. Mutations have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor; DNA binding protein; Transcription factor |
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Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus
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Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor activity; protein homodimerization activity; transcription activator binding; zinc ion binding; acyl-CoA binding; protein binding; DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity; fatty acid binding; palmitoyl-CoA hydrolase activity; receptor binding
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Biological Process: response to cAMP; acyl-CoA metabolic process; regulation of lipid metabolic process; positive regulation of transcription, DNA-dependent; lipid homeostasis; negative regulation of tyrosine phosphorylation of Stat5 protein; glucose homeostasis; negative regulation of cell proliferation; positive regulation of gluconeogenesis; negative regulation of protein import into nucleus, translocation; regulation of gastrulation; response to glucose stimulus; negative regulation of mitotic cell cycle; cell differentiation; regulation of microvillus biogenesis; phospholipid homeostasis; response to drug; transcription initiation from RNA polymerase II promoter; intercellular junction assembly and maintenance; positive regulation of fatty acid biosynthetic process; establishment of tissue polarity; negative regulation of transcription factor activity; endocrine pancreas development; regulation of transcription from RNA polymerase II promoter; xenobiotic metabolic process; ornithine metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process; negative regulation of cell growth; blood coagulation; sex differentiation; regulation of insulin secretion
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Reference #:
P41235 (UniProtKB)
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| Alt. Names/Synonyms: FLJ39654; hepatic nuclear factor 4 alpha; hepatocyte nuclear factor 4, alpha; Hepatocyte nuclear factor 4-alpha; HNF-4-alpha; HNF4; HNF4A; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; HNF4alpha10/11/12; MODY; MODY1; NR2A1; NR2A21; Nuclear receptor subfamily 2 group A member 1; TCF; TCF-14; TCF14; Transcription factor 14; Transcription factor HNF-4; transcription factor-14 |
| Gene Symbols: HNF4A |
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Molecular weight: 52,785 Da
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Basal Isoelectric point: 7.15
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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AMPK Signaling
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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