a nuclear transcription factor which binds DNA as a homodimer. Controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic gene, alpha 1-antitrypsin, apolipoprotein CIII, and transthyretin genes. May be essential for development of the liver, kidney and intestine. Mutations have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; DNA binding protein; Transcription factor
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor activity; protein homodimerization activity; transcription activator binding; zinc ion binding; acyl-CoA binding; protein binding; DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity; fatty acid binding; palmitoyl-CoA hydrolase activity; receptor binding
Biological Process: response to cAMP; acyl-CoA metabolic process; regulation of lipid metabolic process; positive regulation of transcription, DNA-dependent; lipid homeostasis; negative regulation of tyrosine phosphorylation of Stat5 protein; glucose homeostasis; negative regulation of cell proliferation; positive regulation of gluconeogenesis; negative regulation of protein import into nucleus, translocation; regulation of gastrulation; response to glucose stimulus; negative regulation of mitotic cell cycle; cell differentiation; regulation of microvillus biogenesis; phospholipid homeostasis; response to drug; transcription initiation from RNA polymerase II promoter; intercellular junction assembly and maintenance; positive regulation of fatty acid biosynthetic process; establishment of tissue polarity; negative regulation of transcription factor activity; endocrine pancreas development; regulation of transcription from RNA polymerase II promoter; xenobiotic metabolic process; ornithine metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process; negative regulation of cell growth; blood coagulation; sex differentiation; regulation of insulin secretion
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.