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Protein Page:
NPC1L1 (human)

Overview
NPC1L1 Play a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorbtion. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Interacts with RAB11A, MYO5B and RAB11FIP2. Interaction with RAB11A, MYO5B and RAB11FIP2 is required for proper transport to the plasma membrane upon cholesterol depletion. Expression is decreased in Caco-2 cells upon PPARD activation. Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle. Belongs to the patched family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: cytoplasmic vesicle membrane; brush border membrane; apical plasma membrane; integral to membrane; plasma membrane
Molecular Function: protein binding; hedgehog receptor activity; myosin V binding; drug binding; Rab GTPase binding
Biological Process: response to drug; cholesterol transport; cholesterol absorption; lipoprotein metabolic process; signal transduction; cholesterol biosynthetic process; sterol transport
Reference #:  Q9UHC9 (UniProtKB)
Alt. Names/Synonyms: Niemann-Pick C1-like protein 1; NPC1 (Niemann-Pick disease, type C1, gene)-like 1; NPC11L1; NPC1L1; NPCL1
Gene Symbols: NPC1L1
Molecular weight: 148,728 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NPC1L1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S433-p LLGPKNFsGILDLDL
0 1 S658-p LGSYSSWsRVMVDSK
0 1 A739 REVHIGRALGRVAPS
0 1 R742 HIGRALGRVAPSMLL
0 1 S746 ALGRVAPSMLLCSLS
0 1 S1205-p LVSAVGMsVEFVSHI
  mouse

 
S433 LLGPKNFSGILSLDL
S658 LGSYSRWSRVAVDSK
T739-p REAHIGRtLGsVAPs
S742-p HIGRtLGsVAPsMLL
S746-p tLGsVAPsMLLCSLS
S1179 LVTAVGMSVEFVSHI
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