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Protein Page:
MICU1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MICU1 Key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. May act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Belongs to the MICU1 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding protein; Mitochondrial; Membrane protein, integral
Cellular Component: mitochondrial inner membrane; mitochondrial intermembrane space; intracellular
Molecular Function: protein binding; protein heterodimerization activity; calcium ion binding
Biological Process: mitochondrial calcium ion homeostasis; defense response; mitochondrial calcium ion transport; protein homooligomerization; elevation of mitochondrial calcium ion concentration
Reference #:  Q9BPX6 (UniProtKB)
Alt. Names/Synonyms: ara CALC; atopy related autoantigen; Atopy-related autoantigen CALC; CALC; calcium binding atopy-related autoantigen 1; Calcium-binding atopy-related autoantigen 1; CBAA1; CBARA1; DKFZp564C246; EFHA3; FLJ12684; MICU1
Gene Symbols: MICU1
Molecular weight: 54,351 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MICU1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K100-ub APHPEEKkkkRSGFR
0 1 K101-ub PHPEEKkkkRSGFRD
0 1 K102-ub HPEEKkkkRSGFRDR
0 1 - gap
0 1 T269-p DRPTTGNtLKSGLCS
0 3 K294-ub LKGKLTIkNFLEFQR
0 1 Y334 FGGMLLAYSGVQSKK
0 1 S335 GGMLLAYSGVQSKKL
0 1 S339 LAYSGVQSKKLTAMQ
0 1 K357-ub KKHFKEGkGLTFQEV
0 1 K438-ac KEFVSIMkQRLMRGL
  MICU1 iso7  
K100 APHPEEKKKKRSGFR
K101 PHPEEKKKKRSGFRD
K102 HPEEKKKKRSGFRDR
K186-m1 KARFSKKkILHRVRK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
K102 EPYPEDKKKKRSGFR
K103 PYPEDKKKKRSGFRD
K104 YPEDKKKKRSGFRDR
- gap
T271 DRPTTGNTLKSGLCS
K296 LKGKLTIKNFLEFQR
Y336-p FGGMLLAysGVQsKK
S337-p GGMLLAysGVQsKKL
S341-p LAysGVQsKKLTAMQ
K359 KKHFKDGKGLTFQEV
K440 KEFVSIMKQRLMRGL
  rat

 
K102 EPYPEEKKKKRSGFR
K103 PYPEEKKKKRSGFRD
K104 YPEEKKKKRSGFRDR
- gap
T271 DRPTTGNTLKSGLCS
K296 LKGKLTIKNFLEFQR
Y336 FGGMLLAYSGVQSKK
S337 GGMLLAYSGVQSKKL
S341 LAYSGVQSKKLTAMQ
K359 KKHFKDGKGLTFQEV
K440 KEFVSIMKQRLMRGL
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