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Protein Page:
PHKA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PHKA1 regulatory subunit of Phosphorylase Kinase. The phosphorylase kinase holoenzyme consists of a polymer of 16 chains, four each of alpha, beta, gamma, and delta. Alpha and beta are regulatory chains, gamma is the catalytic chain, and delta is calmodulin. LOF mutations cause liver glycogenosis and one form of liver cirrhosis. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Cellular Component: plasma membrane; cytosol
Molecular Function: calmodulin binding; phosphorylase kinase activity; hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process: glycogen metabolic process; generation of precursor metabolites and energy; glycogen catabolic process; carbohydrate metabolic process; glucose metabolic process; protein amino acid phosphorylation
Reference #:  P46020 (UniProtKB)
Alt. Names/Synonyms: KPB1; MGC132604; PHKA; PHKA1; phosphorylase b kinase regulatory subunit alpha skeletal muscle isoform; Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase kinase alpha M subunit; phosphorylase kinase, alpha 1 (muscle); phosphorylase kinase, alpha 1 (muscle), muscle glycogenosis
Gene Symbols: PHKA1
Molecular weight: 137,312 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
Select Structure to View Below

PHKA1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 19 S7-p _MRSRSNsGVRLDGY
0 1 K189 GIWERGDKTNQGISE
0 1 S195 DKTNQGISELNASSV
0 1 S200 GISELNASSVGMAKA
0 1 S201 ISELNASSVGMAKAA
0 1 Y312-p KEDPNRLyYEPAELK
0 1 Y313 EDPNRLyYEPAELKL
0 1 K361 ALEAVLIKGKNGVPL
0 1 M395 HTVDRVPMGKLPHMW
0 1 S405-p LPHMWGQsLyILGSL
0 1 Y407-p HMWGQsLyILGSLMA
0 2 S431-p DPLNRRFstVPkPDV
0 2 T432-p PLNRRFstVPkPDVV
0 1 K435-ub RRFstVPkPDVVVQV
0 1 K452-ub LAETEEIktILKDKG
0 1 T453-p AETEEIktILKDKGI
0 2 Y469-p VETIAEVyPIRVQPA
0 1 Y549-p MLRTDLSyLCSRWRM
0 19 Y636-p SEDYDDNyDyLESGN
0 12 Y638-p DYDDNyDyLESGNWM
0 1 K705 DLMSLVTKAKELHVQ
0 3 Y717-p HVQNVHMyLPTKLFQ
0 4 S726-p PTKLFQAsRPsFNLL
0 9 S729-p LFQAsRPsFNLLDsP
0 7 S735-p PsFNLLDsPHPRQEN
0 31 S758-p IHLPRDQsGEVDFKA
0 1 A765 sGEVDFKALVLQLKE
0 1 S934-p MATELAHsLRCSAEE
0 1 T943-p RCSAEEAtEGLMNLS
2 7 S972-p KEFGVERsVRPtDSN
0 2 T976-p VERsVRPtDSNVsPA
0 3 S981-p RPtDSNVsPAIsIHE
2 10 S985-p SNVsPAIsIHEIGAV
2 0 S1007 TGIMQLKSEIKQVEF
4 1 S1018-p QVEFRRLsIsAESQS
4 1 S1020-p EFRRLsIsAESQSPG
2 0 S1023 RLsIsAESQSPGTSM
1 0 - gap
0 2 S1033-p PGTSMTPssGsFPSA
0 1 S1034-p GTSMTPssGsFPSAY
0 1 S1036-p SMTPssGsFPSAYDQ
0 1 S1049-p DQQSSKDsRQGQWQR
0 1 T1135-p VEAILVLtMLADIEI
0 1 S1144-p LADIEIHsIGSIIAV
0 1 T1201 SGRFGTMTYLSKAAA
0 1 Y1202 GRFGTMTYLSKAAAT
  mouse

► Hide Isoforms
 
S7-p _MRSRSNsGVRLDGY
K189-ub GIWERGDkTNQGIsE
S195-p DkTNQGIsELNAssV
S200-p GIsELNAssVGMAKA
S201-p IsELNAssVGMAKAA
Y312 KEDPNRLYYEPAELK
Y313 EDPNRLYYEPAELKL
K361-ub ALDAVLIkGKNGVPL
M395 HTVDRVPMGKLPHMW
S405 LPHMWGQSLYILGSL
Y407 HMWGQSLYILGSLMA
S431 DPLNRRFSTVPKPDV
T432 PLNRRFSTVPKPDVV
K435 RRFSTVPKPDVVVQV
K452 LAETEEIKAILKDKG
A453 AETEEIKAILKDKGI
Y469 VETIAEVYPIRVQPA
Y549 MLRTDLSYLCSRWRM
Y636 SEDYDEDYEDDLDSG
D639 YDEDYEDDLDSGNWM
K706-ub DLMSLVAkAKELHIQ
Y718 HIQNVHMYLPTKLFQ
S727 PTKLFQPSRPSLNLL
S730 LFQPSRPSLNLLDsP
S736-p PSLNLLDsPESPQDS
S759-p VHLPRDQsGEVDFQs
S766-p sGEVDFQsLVSQLKE
S935 MATELAHSLRCSAEE
T944 RCSAEEATEGLMNLS
S973-p KEFGVERsVRPtDSN
T977-p VERsVRPtDSNVSPA
S982 RPtDSNVSPAIsIHE
S986-p SNVSPAIsIHEIGAV
S1008 TGIMQLKSEIKQVEF
S1019 QVEFRRLSVSMESQT
S1021 EFRRLSVSMESQTSG
S1024 RLSVSMESQTSGGHP
P1031 SQTSGGHPSGVDLMS
S1051 PAACIAASSGSFPTV
S1052 AACIAASSGSFPTVC
S1054 CIAASSGSFPTVCDH
S1067 DHQTSKDSRQGQWQR
T1153 VEAILVLTMLADIEI
S1162 LADIEIHSIGSIIAV
T1219-p SGRFGTMtyLSKAAA
Y1220-p GRFGTMtyLSKAAAT
  PHKA1 iso3  
S7 _MRSRSNSGVRLDGY
K189 GIWERGDKTNQGISE
S195 DKTNQGISELNASSV
S200 GISELNASSVGMAKA
S201 ISELNASSVGMAKAA
Y312 KEDPNRLYYEPAELK
Y313 EDPNRLYYEPAELKL
K361 ALDAVLIKGKNGVPL
K395-ub HTVDRVPkGKLPHMW
S405 LPHMWGQSLYILGSL
Y407 HMWGQSLYILGSLMA
S431 DPLNRRFSTVPKPDV
T432 PLNRRFSTVPKPDVV
K435 RRFSTVPKPDVVVQV
K452 LAETEEIKAILKDKG
A453 AETEEIKAILKDKGI
Y469 VETIAEVYPIRVQPA
Y549 MLRTDLSYLCSRWRM
Y636 SEDYDEDYEDDLDSG
D639 YDEDYEDDLDSGNWM
- gap
Y659 TSNDVHMYLPTKLFQ
S668 PTKLFQPSRPSLNLL
S671 LFQPSRPSLNLLDSP
S677 PSLNLLDSPESPQDS
S700 VHLPRDQSGEVDFQS
S707 SGEVDFQSLVSQLKE
S876 MATELAHSLRCSAEE
T885 RCSAEEATEGLMNLS
S914 KEFGVERSVRPTDSN
T918 VERSVRPTDSNVSPA
S923 RPTDSNVSPAISIHE
S927 SNVSPAISIHEIGAV
S949 TGIMQLKSEIKQVEF
S960 QVEFRRLSVSMESQT
S962 EFRRLSVSMESQTSG
S965 RLSVSMESQTSGGHP
P972 SQTSGGHPSGVDLMS
S992 PAACIAASSGSFPTV
S993 AACIAASSGSFPTVC
S995 CIAASSGSFPTVCDH
S1008 DHQTSKDSRQGQWQR
T1094 VEAILVLTMLADIEI
S1103 LADIEIHSIGSIIAV
T1160 SGRFGTMTYLSKAAA
Y1161 GRFGTMTYLSKAAAT
  rat

 
S7 _MRSRSNSGVRLDSY
K190 GIWERGDKTNQGISE
S196 DKTNQGISELNACSV
C201 GISELNACSVGMAKA
S202 ISELNACSVGMAKAA
Y313 KEDPNRLYyEPAELK
Y314-p EDPNRLYyEPAELKL
K362 ALDAVLIKGKNGVPL
M396 HTVDRVPMGKLPHMW
S406 LPHMWGQSLYILGNL
Y408 HMWGQSLYILGNLMA
S432 DPLNRRFSTVPKPDV
T433 PLNRRFSTVPKPDVV
K436 RRFSTVPKPDVVVQV
K453 LAETEEIKAILKDKG
A454 AETEEIKAILKDKGI
Y470 VETIAEVYPIRVQPA
Y550 MLRTDLSYLCSRWRM
Y637 SEDYDEDYDDELDSG
E640 YDEDYDDELDSGNWM
K707 DLMSLVAKAKELHIQ
Y719 HIQNVHMYLPTKLFQ
S728 PTKLFQPSRPSLNLL
S731 LFQPSRPSLNLLDSP
S737 PSLNLLDSPESPQDS
S760 VHLPRDQSGEVDFQS
S767 SGEVDFQSLVSQLKE
S936 MATELAHSLRCSAEE
T945 RCSAEEATEGLMNLS
S974 KEFGVERSVRPTDSN
T978 VERSVRPTDSNVSPA
S983 RPTDSNVSPAISIHE
S987 SNVSPAISIHEIGAV
S1009 TGIMQLKSEIKQVEF
S1020 QVEFRRLSVSPESQT
S1022 EFRRLSVSPESQTSG
S1025 RLSVSPESQTSGGHP
P1032 SQTSGGHPSSIDLMS
S1052 PAACISASSGSFPTV
S1053 AACISASSGSFPTVC
S1055 CISASSGSFPTVCEP
S1068 EPQTSKDSRQGQWQR
T1154 VEAILVLTMLADIEI
S1163 LADIEIHSIGSIIAV
T1220 SGRFGTMTYLSKAAA
Y1221 GRFGTMTYLSKAAAT
  rabbit

 
S7 _MRSRSNSGVRLDSY
K189 GIWERGDKTNQGISE
S195 DKTNQGISELNASSV
S200 GISELNASSVGMAKA
S201 ISELNASSVGMAKAA
Y312 KEDPNRLYYEPAELK
Y313 EDPNRLYYEPAELKL
K361 ALEAVLIKGKNGVPL
M395 HTVDRVPMGKLPHMW
S405 LPHMWGQSLYILGSL
Y407 HMWGQSLYILGSLMA
S431 DPLNRRFSTVPKPDV
T432 PLNRRFSTVPKPDVV
K435 RRFSTVPKPDVVVQV
K452 LAETEEIKAILKDKG
A453 AETEEIKAILKDKGI
Y469 VETIAEVYPIRVQPA
Y549 MLRTDLSYLCSRWRM
Y636 SEDYDDNYDELESGD
E638 DYDDNYDELESGDWM
K705 DLMSLVTKAKELHVQ
Y717 HVQNVHMYLPTKLFQ
S726 PTKLFQASRPSLNLL
S729 LFQASRPSLNLLDSS
S735 PSLNLLDSSHPSQED
S758 VHLPRDQSGEVDFQA
A765 SGEVDFQALVLQLKE
S934 MATELAHSLRCSAEE
T943 RCSAEEATEGLMNLS
S972-p KEFGVERsVRPTDSN
T976 VERsVRPTDSNVSPA
S981 RPTDSNVSPAIsIHE
S985-p SNVSPAIsIHEIGAV
S1007-p TGIMQLKsEIKQVEF
S1018-p QVEFRRLsIsTEsQP
S1020-p EFRRLsIsTEsQPNG
S1023-p RLsIsTEsQPNGGHs
S1030-p sQPNGGHsLGADLMS
S1050 PGTSVTPSSGSFPGH
S1051 GTSVTPSSGSFPGHH
S1053 SVTPSSGSFPGHHTS
S1063 GHHTSKDSRQGQWQR
T1149 VEAILVLTMLADIEI
S1158 LADIEIHSIGSIIAV
T1215 SGRFGTMTYLSKAAA
Y1216 GRFGTMTYLSKAAAT
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