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Protein Page:
TRAF3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TRAF3 Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. Homotrimer. Heterotrimer with TRAF2 and TRAF5. Interacts with LTBR/TNFRSF3, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF13C TNFRSF17/BCMA, TLR4 and EDAR. Interacts with MAP3K5, MAP3K14, TRAIP/TRIP, TDP2/TTRAP, TANK/ITRAF and TRAF3IP1. Interaction with TNFRSF5/CD40 is modulated by TANK/ITRAF, which competes for the same binding site. Interacts with TICAM1. Interacts with TRAFD1. Interacts with OTUB1, OTUB2 and OTUD5. Interacts with RNF216, MAVS, OPTN and TBK1. Identified in a complex with TRAF2, MAP3K14 and BIRC3. Interacts with BIRC2 and BIRC3. Upon exposure to bacterial lipopolysaccharide (LPS), recruited to a transient complex containing TLR4, TRAF3, TRAF6, IKBKG, MAP3K7, MYD88, TICAM1, BIRC2, BIRC3 and UBE2N. Interacts with Epstein-Barr virus protein LMP1. Interacts (via RING-type zinc finger domain) with SRC. Belongs to the TNF receptor-associated factor family. A subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Cellular Component: internal side of plasma membrane; mitochondrion; cytosol; endosome
Molecular Function: protein binding; signal transducer activity; zinc ion binding; thioesterase binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; tumor necrosis factor receptor binding; protein kinase binding; ligase activity
Biological Process: apoptosis; MyD88-independent toll-like receptor signaling pathway; regulation of defense response to virus; protein ubiquitination; toll-like receptor 3 signaling pathway; signal transduction; Toll signaling pathway; regulation of cytokine production; regulation of apoptosis; tumor necrosis factor-mediated signaling pathway; inhibition of NF-kappaB transcription factor; regulation of proteolysis; toll-like receptor signaling pathway; innate immune response; regulation of interferon-beta production; toll-like receptor 4 signaling pathway; negative regulation of interferon type I production
Reference #:  Q13114 (UniProtKB)
Alt. Names/Synonyms: CAP-1; CAP1; CD40 associated protein 1; CD40 binding protein; CD40 receptor associated factor 1; CD40 receptor-associated factor 1; CD40-binding protein; CD40BP; CRAF1; LAP1; LMP1 associated protein; LMP1-associated protein 1; TNF receptor-associated factor 3; TRAF3
Gene Symbols: TRAF3
Molecular weight: 64,490 Da
Basal Isoelectric point: 8.23  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TRAF3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S9-p ESSKKMDsPGALQTN
0 2 T29-p HTDRSAGtPVFVPEQ
0 1 Y39-p FVPEQGGyKEKFVKT
0 3 K40 VPEQGGyKEKFVKTV
0 2 K42 EQGGyKEKFVKTVED
0 1 K64 HLVLCSPKQTECGHR
0 1 S269 LLKEWSNSLEKKVSL
0 1 K329 VIDSQAEKLKELDKE
0 1 S349 QNWEEADSMkSSVES
0 1 K351-ub WEEADSMkSSVESLQ
0 30 K369-ub TELESVDkSAGQVAR
0 1 K513-ub RHLGDAFkPDPNSSS
0 2 K557-ub KDDTIFIkVIVDTSD
  mouse

 
A9 ESSKKMDAAGTLQPN
S29 QPDRGAGSVLVPEQG
Y38 LVPEQGGYkEkFVKT
K39-ub VPEQGGYkEkFVKTV
K41-ub EQGGYkEkFVKTVED
K63-ub RLVLCNPkQTECGHR
S268-p LLKEWSNsLEKKVSL
K328-ac VIDSQAEkLKELDKE
S348-p QNWEEADsMKSSVES
K350 WEEADsMKSSVESLQ
K368-ub TELESVDkSAGQAAR
K512 RHLGDAFKPDPNSSS
K556 KDDTIFIKVIVDTSD
  rat

 
A9 EPSKKMGAAGAAQPN
S29 QPDRGAASVLVPEQG
Y38 LVPEQGGYKEKFAKT
K39 VPEQGGYKEKFAKTV
K41 EQGGYKEKFAKTVED
K63 RLVLCNPKQTECGHR
S268 LLKEWSNSLEKKVSL
K328 VIDSQAEKLKELDKE
S348 QNWEEADSMKSSVES
K350 WEEADSMKSSVESLQ
K368 TELESVDKSAGQAAR
K512 RHLGDAFKPDPNSSS
K556 KDDTIFIKVIVDTSD
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