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Protein Page:
PIK3CG (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIK3CG catalytic subunit of the PI3/PI4-kinase family of phospholipid-kinases. Phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. Phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 recruits proteins with PH domains to the membrane, including AKT1 and PDPK1, and plays a critical pleiotropic role in regulating membrane signaling. Activated by both the alpha and the beta:gamma G proteins following stimulation of G protein-coupled receptors (GPCRs), linking GPCR activation to PIP3 production.. Activation by GPCRs is assisted by the regulatory subunits (PIK3R5 or PIK3R6), leading to the translocation from the cytosol to the plasma membrane. Inhibited by AS-604850 and AS-605240. Activates signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD, it regulates many cellular functions: it is involved in natural killer (NK) cell development and migration towards the sites of inflammation; participates in T-lymphocyte development and migration; required for B-lymphocyte development and signaling; regulates lymphocyte cytokine production; participates in neutrophil respiratory burst, chemotaxis and extravasation; promotes platelet aggregation and thrombosis; regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism; involved in endothelial progenitor cell migration; modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels; regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1 and by non-muscle tropomyosin phosphorylation; and contributes to cardiac hypertrophy under pathological stress. Possesses serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. Holoenzyme is a trimer composed of a heterodimer of a catalytic subunit PIK3CG and a PIK3R5 or PIK3R6 regulatory subunit. Interacts with HRAS1; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; EC 2.7.1.153; Motility/polarity/chemotaxis; Autophagy; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid
Cellular Component: mast cell granule; membrane; cytoplasm; plasma membrane; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; ephrin receptor binding; 1-phosphatidylinositol-3-kinase activity; phosphoinositide 3-kinase activity; ATP binding; phosphatidylinositol-4-phosphate 3-kinase activity; protein kinase activity
Biological Process: respiratory burst during defense response; phosphoinositide 3-kinase cascade; T cell activation; protein amino acid phosphorylation; T cell proliferation; positive regulation of MAP kinase activity; regulation of cell adhesion mediated by integrin; elevation of cytosolic calcium ion concentration; positive regulation of acute inflammatory response; phosphoinositide phosphorylation; phospholipid metabolic process; dendritic cell chemotaxis; angiogenesis; inflammatory response; neutrophil chemotaxis; platelet activation; adaptive immune response; cytokine production; endocytosis; mast cell degranulation; G-protein coupled receptor protein signaling pathway; positive regulation of protein kinase B signaling cascade; phosphatidylinositol biosynthetic process; innate immune response; blood coagulation; secretory granule localization
Reference #:  P48736 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol 3-kinase; p110-gamma; p120-PI3K; phosphatidylinositol 3 kinase gamma, p110 gamma; phosphatidylinositol 3-kinase catalytic 110-kD gamma; phosphatidylinositol 3-kinase, catalytic, gamma polypeptide; Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphoinositide-3-kinase gamma catalytic subunit; phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3-kinase subunit gamma; PI3CG; PI3K; PI3K-gamma; PI3Kgamma; PIK3; PIK3CG; PK3CG; PtdIns-3-kinase subunit gamma; PtdIns-3-kinase subunit p110-gamma
Gene Symbols: PIK3CG
Molecular weight: 126,454 Da
Basal Isoelectric point: 7.23  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-├č Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PIK3CG

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y6 __MELENYKQPVVLR
0 1 S227-p IFIVIHRsttsQtIK
0 2 T228-p FIVIHRsttsQtIKV
0 1 T229-p IVIHRsttsQtIKVS
0 1 S230-p VIHRsttsQtIKVSP
0 2 T232-p HRsttsQtIKVSPDD
0 1 T250-p AILQSFFtKMAKKKS
1 0 S582-p LWHFRYEsLKHPKAY
0 1 K606-ub GQQEIVAkTYQLLAR
0 1 S620-p RREVWDQsALDVGLt
0 1 T627-p sALDVGLtMQLLDCN
0 1 S636-p QLLDCNFsDENVRAI
0 1 T746-p IEMLQKVtLDIKSLS
0 1 Y757-p KSLSAEKyDVSSQVI
0 1 S853-p QILRIMEsIWETESL
0 1 T899 QQSTVGNTGAFKDEV
0 2 S974 HILGNYKSFLGINKE
0 1 K1000-ac FVMGTSGkKTSPHFQ
1 0 T1024-p YLALRHHtNLLIILF
2 0 S1101-p IKQGEKHsA______
  mouse

 
Y6-p __MELENyEQPVVLR
G227 IFIVIHRGTTSQTIK
T228 FIVIHRGTTSQTIKV
T229 IVIHRGTTSQTIKVS
S230 VIHRGTTSQTIKVSA
T232 HRGTTSQTIKVSADD
T250 TILQSFFTKMAKKKS
S582 LWHFRYESLKHPKAY
K606 GQQEIVAKTYQLLAR
S620 RREIWDQSALDVGLT
T627 SALDVGLTMQLLDCN
S636 QLLDCNFSDENVRAI
T746 IEMLQKVTIDIKSLS
Y757 KSLSAEKYDVSSQVI
S853 QILRIMESIWETESL
T899-p QQSTVGNtGAFKDEV
S974-p HILGNYKsFLGINKE
K1000 FVMGSSGKKTSPHFQ
T1024 YLALRHHTNLLIILF
S1101 IKQGEKHSA______
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