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PIK3CG (human)

Overview PIK3CG a member of the PI3/4-kinase family of proteins. Phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. An important modulator of extracellular signals including the E-cadherin-mediated cell-cell adhesion pathway. Promotes the assembly of adherens junctions and may play a pivotal role in the regulation of cytotoxicity in NK cells. Note: This description may include information from UniProtKB. Protein type: Autophagy; Kinase, lipid; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; EC 2.7.11.1; Motility/polarity/chemotaxis Cellular Component: membrane; cytoplasm; plasma membrane; cytosol Molecular Function: protein serine/threonine kinase activity; protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; ephrin receptor binding; 1-phosphatidylinositol-3-kinase activity; ATP binding; phosphoinositide 3-kinase activity; protein kinase activity Biological Process: respiratory burst during defense response; neutrophil chemotaxis; platelet activation; adaptive immune response; phosphoinositide 3-kinase cascade; T cell activation; cytokine production; endocytosis; mast cell degranulation; T cell proliferation; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; positive regulation of MAP kinase activity; regulation of cell adhesion mediated by integrin; positive regulation of acute inflammatory response; phospholipid metabolic process; phosphatidylinositol biosynthetic process; innate immune response; dendritic cell chemotaxis; angiogenesis; blood coagulation; inflammatory response; secretory granule localization; negative regulation of apoptosis Reference #:  P48736 (UniProtKB) Alt. Names/Synonyms: 1-phosphatidylinositol 3-kinase; p110-gamma; p120-PI3K; phosphatidylinositol 3 kinase gamma, p110 gamma; phosphatidylinositol 3-kinase catalytic 110-kD gamma; phosphatidylinositol 3-kinase, catalytic, gamma polypeptide; Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphoinositide-3-kinase gamma catalytic subunit; phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3-kinase subunit gamma; PI3CG; PI3K; PI3K-gamma; PI3Kgamma; PIK3; PIK3CG; PK3CG; PtdIns-3-kinase subunit gamma; PtdIns-3-kinase subunit p110-gamma Gene Symbols: PIK3CG Molecular weight: 126,454 Da Basal Isoelectric point: 7.23  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCRs Signaling to MAPK/Erk  |  Inhibition of Apoptosis  |  Jak/Stat/IL-6 Signaling  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  Regulation of Actin Dynamics  |  Regulation of Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PIK3CG 1E8Y - A=144-1102 (human) 1E8Z - A=144-1102 (human) 1HE8 - A=144-1102 (human) 2A4Z - A=144-1102 (human) 2A5U - A=144-1102 (human) 2CHW - A=144-1102 (human) 2CHX - A=144-1102 (human) 2CHZ - A=144-1102 (human) 2V4L - A=144-1102 (human) 3APC - A=144-1102 (human) 3APD - A=144-1102 (human) 3APF - A=144-1102 (human) 3CSF - A=144-1102 (human) 3CST - A=144-1102 (human) 3DBS - A=144-1102 (human) 3DPD - A=144-1102 (human) 3ENE - A=144-1102 (human) 3IBE - A=144-1102 (human) 3L08 - A=144-1102 (human) 3L13 - A=144-1102 (human) 3L16 - A=144-1102 (human) 3L17 - A=144-1102 (human) 3L54 - A=144-1102 (human) 3LJ3 - A=144-1102 (human) 3MJW - A=144-1102 (human) 3ML8 - A=144-1102 (human) 3ML9 - A=144-1102 (human) 3NZS - A=147-1094 (human) 3NZU - A=147-1094 (human) 3OAW - A=144-1102 (human) 3P2B - A=144-1102 (human) 3PRE - A=144-1102 (human) 3PRZ - A=144-1102 (human) 3PS6 - A=144-1102 (human) 3QAQ - A=144-1102 (human) 3QAR - A=144-1102 (human) 3QJZ - A=144-1102 (human) 3QK0 - A=144-1102 (human) 3R7Q - A=144-1102 (human) 3R7R - A=144-1102 (human) 3S2A - A=144-1102 (human) 3SD5 - A=144-1102 (human) 3T8M - A=144-1102 (human) 3TJP - A=144-1102 (human) 3TL5 - A=144-1102 (human) 3ZVV - A=144-1102 (human) 3ZW3 - A=144-1102 (human) 4ANU - A=144-1102 (human) 4ANV - A=144-1102 (human) 4ANW - A=144-1102 (human) 4ANX - A=144-1102 (human) 4AOF - A=144-1102 (human) 4DK5 - A=144-1102 (human) 4EZJ - A=144-1102 (human) 4EZK - A=144-1102 (human) 4EZL - A=144-1102 (human) 4F1S - A=144-1102 (human) 4FA6 - A=144-1102 (human) 4FAD - A=144-1102 (human) 4FHJ - A=144-1102 (human) 4FHK - A=144-1102 (human) 4FJY - A=144-1102 (human) 4FJZ - A=144-1102 (human) 4FLH - A=144-1102 (human) 4FUL - A=144-1102 (human) 4G11 - A=144-1102 (human) 4GB9 - A=144-1102 (human) 4HLE - A=144-1102 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L 3APC 3APD 3APF 3CSF 3CST 3DBS 3DPD 3ENE 3IBE 3L08 3L13 3L16 3L17 3L54 3LJ3 3MJW 3ML8 3ML9 3NZS 3NZU 3OAW 3P2B 3PRE 3PRZ 3PS6 3QAQ 3QAR 3QJZ 3QK0 3R7Q 3R7R 3S2A 3SD5 3T8M 3TJP 3TL5 3ZVV 3ZW3 4ANU 4ANV 4ANW 4ANX 4AOF 4DK5 4EZJ 4EZK 4EZL 4F1S 4FA6 4FAD 4FHJ 4FHK 4FJY 4FJZ 4FLH 4FUL 4G11 4GB9 4HLE  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y6	__MELENYKQPVVLR
0	1		S227-p	IFIVIHRsttsQTIK
0	2		T228-p	FIVIHRsttsQTIKV
0	1		T229-p	IVIHRsttsQTIKVS
0	1		S230-p	VIHRsttsQTIKVSP
0	1		T250-p	AILQSFFtKMAKKKS
0	1		K606-u	GQQEIVAkTYQLLAR
0	1		S620-p	RREVWDQsALDVGLt
0	1		T627-p	sALDVGLtMQLLDCN
0	1		S636-p	QLLDCNFsDENVRAI
0	1		Y757-p	KSLSAEKyDVSSQVI
0	1		T899	QQSTVGNTGAFKDEV
0	1		S974	HILGNYKSFLGINKE
0	1		K1000-a	FVMGTSGkKTSPHFQ
1	0		T1024-p	YLALRHHtNLLIILF
2	0		S1101-p	IKQGEKHsA______

	mouse
Y6-p	__MELENyEQPVVLR
G227	IFIVIHRGTTSQTIK
T228	FIVIHRGTTSQTIKV
T229	IVIHRGTTSQTIKVS
S230	VIHRGTTSQTIKVSA
T250	TILQSFFTKMAKKKS
K606	GQQEIVAKTYQLLAR
S620	RREIWDQSALDVGLT
T627	SALDVGLTMQLLDCN
S636	QLLDCNFSDENVRAI
Y757	KSLSAEKYDVSSQVI
T899-p	QQSTVGNtGAFKDEV
S974-p	HILGNYKsFLGINKE
K1000	FVMGSSGKKTSPHFQ
T1024	YLALRHHTNLLIILF
S1101	IKQGEKHSA______

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