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Protein Page:
PIK3CB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIK3CB catalytic subunit of phosphoinositide-3-kinase beta. Catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration and cell survival. PTEN reverses this process, and the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. Expressed ubiquitously. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; Kinase, lipid
Cellular Component: plasma membrane; phosphoinositide 3-kinase complex; cytosol; nucleus
Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; insulin receptor substrate binding; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; phosphoinositide 3-kinase activity; ATP binding
Biological Process: phosphoinositide 3-kinase cascade; nerve growth factor receptor signaling pathway; activation of MAPK activity; regulation of cell-matrix adhesion; chemotaxis; signal transduction; T cell receptor signaling pathway; embryonic cleavage; phosphoinositide phosphorylation; phospholipid metabolic process; positive regulation of autophagy; epidermal growth factor receptor signaling pathway; platelet activation; cell migration; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; insulin receptor signaling pathway; phosphatidylinositol biosynthetic process; innate immune response; autophagy; homophilic cell adhesion; blood coagulation; leukocyte migration; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P42338 (UniProtKB)
Alt. Names/Synonyms: catalytic phosphatidylinositol 3-kinase beta; DKFZp779K1237; MGC133043; P110BETA; Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K-beta; PI3KBETA; PIK3C1; PIK3CB; PK3CB; PtdIns-3-kinase p110; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta
Gene Symbols: PIK3CB
Molecular weight: 122,762 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-├č Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PIK3CB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T113-p LPVLKLVtRsCDPGE
0 1 S115-p VLKLVtRsCDPGEKL
0 1 K159-ac MRKFSEEkILSLVGL
0 1 K173-ac LSWMDWLkQTYPPEH
0 1 K230-ub VNELAIQkRLTIHGK
0 1 Y244-p KEDEVSPyDyVLQVS
0 3 Y246-p DEVSPyDyVLQVSGR
0 4 S324 PKKTRIISHVWENNN
0 1 S416-p DKVKTKKstKTINPs
0 1 T417-p KVKTKKstKTINPsK
0 3 S423-p stKTINPsKyQtIRK
0 39 Y425-p KTINPsKyQtIRKAG
0 4 T427-p INPsKyQtIRKAGKV
0 1 Y436-p RKAGKVHyPVAWVNT
0 10 Y503-p PENKKQPyyyPPFDK
0 15 Y504-p ENKKQPyyyPPFDKI
0 10 Y505-p NKKQPyyyPPFDKII
0 1 K514-ub PFDKIIEkAAEIAsS
0 1 S520-p EkAAEIAsSDSANVS
0 1 T721-p EALNKLKtLNsLIKL
0 1 S724-p NKLKtLNsLIKLNAV
0 14 Y772-p CVILSELyVEKCKYM
0 1 K828-ub RLMDLLWkEAGLDLR
0 1 K886-ub DALLNWLkEYNSGDD
0 1 S947-p HILGNFKsKFGIKRE
0 3 T961-p ERVPFILtyDFIHVI
0 129 Y962-p RVPFILtyDFIHVIQ
0 2 K1025-ub VKDIQYLkDSLALGK
2 0 S1070-p TVRKDYRs_______
  mouse

 
T107 LPVLKLVTRSCDPAE
S109 VLKLVTRSCDPAEKL
K153 MRKFSEAKIQSLVGL
K167 LSWIDWLKHTYPPEH
K224 INELAIQKRLTIRGK
C238 KEDEASPCDYVLQVS
Y240 DEASPCDYVLQVSGR
S318-p PKKTRVIsHIWDNNN
S410 DKVKTKKSTKTINPS
T411 KVKTKKSTKTINPSK
S417 STKTINPSKyQTIRK
Y419-p KTINPSKyQTIRKAG
T421 INPSKyQTIRKAGKV
Y430 RKAGKVHYPVAWVNT
C497 PENKKQPCyYPPFDK
Y498-p ENKKQPCyYPPFDKI
Y499 NKKQPCyYPPFDKII
K508 PFDKIIEKAAELASG
S514 EKAAELASGDSANVS
T715 EALNKLKTLNSLIKL
S718 NKLKTLNSLIKLNAV
Y766-p CVILSELyVEKCKYM
K822 RLMDLLWKEAGLDLR
K880 DALLNWLKEYNSGDD
S941 HILGNFKSKFGIKRE
T955 ERVPFILTyDFIHVI
Y956-p RVPFILTyDFIHVIQ
K1019-ub VKDIQYLkDSLALGK
S1064 TVRKDYRS_______
  rat

 
T113 LPVLKLVTRSCDPAE
S115 VLKLVTRSCDPAEKL
K159 MRKFSEDKIQSLVGL
K173 LSWIDWLKHTYPPEH
K230 INELAIQKRLTIRGK
C244 KEEEASPCDYVLQVS
Y246 EEASPCDYVLQVSGR
S324 PKKTRVISHVWGNNN
S416 DKVKTKKSTKTINPS
T417 KVKTKKSTKTINPSK
S423 STKTINPSKYQTIRK
Y425 KTINPSKYQTIRKAG
T427 INPSKYQTIRKAGKV
Y436 RKAGKVHYPVAWVNT
Y503 PENKKQPYYYPPFDK
Y504 ENKKQPYYYPPFDKI
Y505 NKKQPYYYPPFDKII
K514 PFDKIIEKAAEIASG
S520 EKAAEIASGDSANVS
T721 EALNKLKTLNSLIKL
S724 NKLKTLNSLIKLNAM
Y772 CVILSELYVEKCRYM
K828 RLMDLLWKEAGLDLR
K886 DALLNWLKEYNSGDD
S947 HILGNFKSKFGIKRE
T961 ERVPFILTyDFIHVI
Y962-p RVPFILTyDFIHVIQ
K1025 VKDIQYLKDSLALGK
S1070 TVRKDYRS_______
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