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WIP (human)

Overview WIP a cytoskeleton-associated protein that interacts with the Wiskott-Aldrich syndrome protein (WASP) in resting cells. Plays an important role in the organization of the actin cytoskeleton. Phosphorylation by PKC-theta following T cell receptor signaling disengages it from WASP, releasing WASP from WIP inhibition. Binds to a region of WASP that is frequently mutated in Wiskott-Aldrich syndrome. Note: This description may include information from UniProtKB. Protein type: Actin binding protein; Motility/polarity/chemotaxis Cellular Component: cytoplasmic membrane-bound vesicle; actin filament; actin cytoskeleton Molecular Function: protein binding; actin binding; profilin binding Biological Process: positive regulation of protein export from nucleus; actin filament-based movement; actin polymerization and/or depolymerization; protein complex assembly Reference #:  O43516 (UniProtKB) Alt. Names/Synonyms: MGC111041; Protein PRPL-2; PRPL-2; WAS/WASL interacting protein family, member 1; WAS/WASL-interacting protein family member 1; WASP-interacting protein; WASPIP; WIP; WIPF1; Wiskott-Aldrich syndrome protein interacting protein; Wiskott-Aldrich syndrome protein-interacting protein Gene Symbols: WIPF1 Molecular weight: 51,258 Da Basal Isoelectric point: 11.47  Predict pI for various phosphorylation states

Select Structure to View Below WIP 1MKE - A=- (human) 2A41 - C=29-60 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1MKE 2A41  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: S488‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	9		R33-m2	NKTEQAGrNALLSDI
0	1		S91-p	GGGGGGGsFGGGGPP
0	5		R134-m1	PLLPPGGrSTSAKPF
0	3		S142-p	STSAKPFsPPSGPGr
0	1		R149-m2	sPPSGPGrFPVPsPG
0	5		S154-p	PGrFPVPsPGHRSGP
0	1		R211-m2	PPVPGGPrQPsPGPT
0	1		S214-p	PGGPrQPsPGPTPPP
0	1		R226-m1	PPPFPGNrGTALGGG
0	2		S234-p	GTALGGGsIRQSPLS
0	4		S276-p	PPVGNRPsIHREAVP
0	21		S340-p	RLPQRNLsLSSstPP
0	1		S342	PQRNLsLSSstPPLP
0	1		S344-p	RNLsLSSstPPLPsP
0	19		T345-p	NLsLSSstPPLPsPG
0	22		S350-p	SstPPLPsPGRSGPL
0	7		T398-p	TSRALPAtPQLPSRS
3	0		S488-p	RNESRSGsNRRERGA

	mouse
R33-m2	NKTEQAGrNALLSDI
N92	GGGGSGGNFGGGGPP
R135-m1	PILPPGGrATSAKPF
S143-p	ATSAKPFsPPSGPGR
R150	sPPSGPGRFPAPSPG
S155	PGRFPAPSPGHRSGP
R212	PAGLGAPRPPFPGNR
-	gap
R219	RPPFPGNRGAAFGAG
S227	GAAFGAGSARQNPSG
S268-p	PPVGNRPsMHREAVP
S330-p	RLPQRNLsLtSSAPP
T332-p	PQRNLsLtSSAPPLP
S334	RNLsLtSSAPPLPsP
A335	NLsLtSSAPPLPsPG
S340-p	SSAPPLPsPGRSGPL
T388-p	TARALPAtPQLPSRS
S478	RNESRSGSNRRERGA

	rat
R33	NKTEQAGRNALLSDI
N87	GSSGGGGNFGGGGPP
R130	PILPPGGRATSAKPF
S138	ATSAKPFSSPSGPGR
R145	SSPSGPGRFPAPSPG
S150	PGRFPAPSPGHRSGP
R207	PAGLGAPRPPFPGNR
-	gap
R214	RPPFPGNRGAAFGAG
S222	GAAFGAGSVRQNLSS
S263	PPVGNRPSMHREAVP
S324-p	RLPQRNLsLTSPTPP
T326	PQRNLsLTSPTPPLP
P328	RNLsLTSPTPPLPSP
T329	NLsLTSPTPPLPSPG
S334	SPTPPLPSPGRSGPL
T382	TARALPATPQLPSRS
S472	RSESRSGSNRRERGA

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