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Protein Page:
TMPRSS3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TMPRSS3 Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro). Defects in TMPRSS3 are the cause of deafness autosomal recessive type 8 (DFNB8). DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in TMPRSS3 are the cause of deafness autosomal recessive type 10 (DFNB10). Belongs to the peptidase S1 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Endoplasmic reticulum; EC 3.4.21.-; Protease
Cellular Component: endoplasmic reticulum membrane; cell soma; endoplasmic reticulum; integral to membrane
Molecular Function: sodium channel regulator activity; serine-type endopeptidase activity; scavenger receptor activity
Biological Process: receptor-mediated endocytosis; cellular sodium ion homeostasis; sensory perception of sound; proteolysis
Reference #:  P57727 (UniProtKB)
Alt. Names/Synonyms: DFNB10; DFNB8; ECHOS1; Serine protease TADG-12; serine protease TADG12; TADG12; TMPRSS3; TMPS3; Transmembrane protease serine 3; transmembrane protease, serine 3; Tumor-associated differentially-expressed gene 12 protein
Gene Symbols: TMPRSS3
Molecular weight: 49,405 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Select Structure to View Below

TMPRSS3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 K99-ub CDGVSDCkDGEDEYR
  mouse

 
K99 CDGVSDCKNAEDEYR
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