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Protein Page:
TMPRSS3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

TMPRSS3 Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro). Defects in TMPRSS3 are the cause of deafness autosomal recessive type 8 (DFNB8). DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in TMPRSS3 are the cause of deafness autosomal recessive type 10 (DFNB10). Belongs to the peptidase S1 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protease; EC 3.4.21.-; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: endoplasmic reticulum membrane; cell soma; endoplasmic reticulum; integral to membrane
Molecular Function: sodium channel regulator activity; serine-type endopeptidase activity; scavenger receptor activity
Biological Process: receptor-mediated endocytosis; cellular sodium ion homeostasis; sensory perception of sound; proteolysis
Disease: Deafness, Autosomal Recessive 8
Reference #:  P57727 (UniProtKB)
Alt. Names/Synonyms: DFNB10; DFNB8; ECHOS1; Serine protease TADG-12; serine protease TADG12; TADG12; TMPRSS3; TMPS3; Transmembrane protease serine 3; transmembrane protease, serine 3; Tumor-associated differentially-expressed gene 12 protein
Gene Symbols: TMPRSS3
Molecular weight: 49,405 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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