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Protein Page:
USH1G (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
USH1G Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Defects in USH1G are the cause of Usher syndrome type 1G (USH1G). USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: plasma membrane; cytosol; actin cytoskeleton
Molecular Function: protein binding; protein homodimerization activity; spectrin binding
Biological Process: inner ear morphogenesis; sensory perception of sound; inner ear receptor cell differentiation; sensory perception of light stimulus; photoreceptor cell maintenance; equilibrioception
Reference #:  Q495M9 (UniProtKB)
Alt. Names/Synonyms: ANKS4A; FLJ33924; SANS; Scaffold protein containing ankyrin repeats and SAM domain; USH1G; Usher syndrome 1G (autosomal recessive); Usher syndrome type-1G protein
Gene Symbols: USH1G
Molecular weight: 51,489 Da
Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states
Select Structure to View Below

USH1G

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S179-p RSDTLSFsSLtSSTL
0 1 T182-p TLSFsSLtSSTLsRR
0 1 S187-p SLtSSTLsRRLQHLA
0 1 K224-ac QKKLERRkQGGEGTF
0 1 S356-p SPSLDDDsLGSANsL
0 1 S362-p DsLGSANsLQDRSCG
0 1 K412 AALLRQEKIDLEALM
  mouse

 
S179 RSDTLSFSSLTSSTL
T182 TLSFSSLTSSTLSRR
S187 SLTSSTLSRRLQHMT
K224 QKKLERRKQGGEGTF
S356 SPSLDDDSLGSANSL
S362 DSLGSANSLQDRSCG
K412-ac ASLLRHEkIDLEALM
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