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INHA (human)

Overview INHA Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family. Note: This description may include information from UniProtKB. Protein type: Secreted, signal peptide; Secreted Cellular Component: photoreceptor outer segment; photoreceptor inner segment; cell soma; extracellular region Molecular Function: protein binding; growth factor activity; protein heterodimerization activity; hormone activity; cytokine activity; receptor binding Biological Process: negative regulation of B cell differentiation; hemoglobin biosynthetic process; nervous system development; regulation of cell cycle; male gonad development; signal transduction; negative regulation of interferon-gamma biosynthetic process; negative regulation of cell cycle; regulation of cell proliferation; negative regulation of follicle-stimulating hormone secretion; response to external stimulus; cell surface receptor linked signal transduction; negative regulation of macrophage differentiation; cell-cell signaling; ovarian follicle development; induction of apoptosis; erythrocyte differentiation; negative regulation of phosphorylation; positive regulation of follicle-stimulating hormone secretion; cell differentiation; cell cycle arrest; skeletal development Reference #:  P05111 (UniProtKB) Alt. Names/Synonyms: A-inhibin subunit; INHA; Inhibin alpha chain; inhibin, alpha Gene Symbols: INHA Molecular weight: 39,670 Da Basal Isoelectric point: 8.29  Predict pI for various phosphorylation states

Select Structure to View Below INHA

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T204	LLRCPLCTCSARPEA
0	1		S206	RCPLCTCSARPEATP
0	1		A211	TCSARPEATPFLVAH
0	1		T212	CSARPEATPFLVAHT
0	1		S233-p	GGERARRstPLMSWP
0	1		T234-p	GERARRstPLMSWPW
0	1		S244-p	MSWPWSPsALRLLQR

	mouse
S205-p	LLRCPLCsCsGRPEt
S207-p	RCPLCsCsGRPEttP
T212-p	sCsGRPEttPFLVAH
T213-p	CsGRPEttPFLVAHT
S234	AGERARRSTPSVPWP
T235	GERARRSTPSVPWPW
A245	VPWPWSPAALRLLQR

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