The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Belongs to the intercrine delta family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Cellular Component: extracellular space; cell surface; cell projection; perinuclear region of cytoplasm; extracellular region; plasma membrane; integral to membrane
Molecular Function: protein binding; chemokine activity; receptor binding
Biological Process: positive regulation of transforming growth factor-beta1 production; neutrophil chemotaxis; platelet activation; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; leukocyte chemotaxis; negative regulation of cytokine secretion; defense response; angiogenesis involved in wound healing; leukocyte adhesive activation; macrophage chemotaxis; negative regulation of vasoconstriction; regulation of inhibitory postsynaptic membrane potential; positive regulation of angiogenesis; positive regulation of calcium-independent cell-cell adhesion; response to hypoxia; immune response; cell adhesion; lymphocyte chemotaxis; positive regulation of inflammatory response; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.