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CX3CL1 (human)

Overview CX3CL1 The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Belongs to the intercrine delta family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis Cellular Component: extracellular space; cell surface; cell projection; perinuclear region of cytoplasm; extracellular region; plasma membrane; integral to membrane Molecular Function: protein binding; chemokine activity; receptor binding Biological Process: positive regulation of transforming growth factor-beta1 production; neutrophil chemotaxis; platelet activation; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; leukocyte chemotaxis; negative regulation of cytokine secretion; defense response; angiogenesis involved in wound healing; leukocyte adhesive activation; macrophage chemotaxis; negative regulation of vasoconstriction; regulation of inhibitory postsynaptic membrane potential; positive regulation of angiogenesis; positive regulation of calcium-independent cell-cell adhesion; response to hypoxia; immune response; cell adhesion; lymphocyte chemotaxis; positive regulation of inflammatory response; negative regulation of apoptosis Reference #:  P78423 (UniProtKB) Alt. Names/Synonyms: ABCD-3; C-X3-C motif chemokine 1; C3Xkine; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; CX3CL1; CXC3; CXC3C; FKN; Fractalkine; Neurotactin; NTN; NTT; Processed fractalkine; SCYD1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; Small-inducible cytokine D1; X3CL1 Gene Symbols: CX3CL1 Molecular weight: 42,203 Da Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states

Select Structure to View Below CX3CL1 1B2T - A=25-100 (human) 1F2L - A/D/C/B=25-100 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1B2T 1F2L  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T97-p	DRQAAALtRNGGTFE
0	3		R262	RPENSLEREEMGPVP
0	1		K371	SLQGCPRKMAGEMAE
0	1		S389	YIPRSCGSNSYVLVP
0	1		S391	PRSCGSNSYVLVPV_

	mouse
T97	DHQAAALTKNGGKFE
S262-p	SPEKSLGsEEINPVH
K369-u	SLQGCPRkMAGEMVE
S387-p	YVPRSCGsNsYVLVP
S389-p	PRSCGsNsYVLVPV_

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