Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Homodimer. Belongs to the NGF-beta family. Note: This description may include information from UniProtKB.
Molecular Function: metalloendopeptidase inhibitor activity; nerve growth factor receptor binding; protein binding; growth factor activity; receptor signaling protein activity
Biological Process: positive regulation of neuron maturation; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; activation of MAPKK activity; regulation of neuron differentiation; positive regulation of apoptosis; positive regulation of axon extension; regulation of neurotransmitter secretion; regulation of axonogenesis; regulation of caspase activity; sensory perception of pain; regulation of release of sequestered calcium ion into cytosol; peripheral nervous system development; negative regulation of cell cycle; nerve growth factor processing; neuron apoptosis; induction of apoptosis via death domain receptors; cell-cell signaling; phospholipase C activation; positive regulation of protein ubiquitination; small GTPase mediated signal transduction; Ras protein signal transduction; positive regulation of axonogenesis; negative regulation of neuron apoptosis; positive regulation of collateral sprouting; neurite morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.