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Protein Page:
NGF (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

NGF Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Homodimer. Belongs to the NGF-beta family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1p13.1
Cellular Component: Golgi lumen; cytoplasmic membrane-bound vesicle; extracellular region; endosome
Molecular Function: metalloendopeptidase inhibitor activity; nerve growth factor receptor binding; protein binding; growth factor activity; receptor signaling protein activity
Biological Process: positive regulation of neuron maturation; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; activation of MAPKK activity; regulation of neuron differentiation; positive regulation of apoptosis; positive regulation of axon extension; regulation of neurotransmitter secretion; regulation of axonogenesis; regulation of caspase activity; sensory perception of pain; regulation of release of sequestered calcium ion into cytosol; peripheral nervous system development; negative regulation of cell cycle; nerve growth factor processing; neuron apoptosis; induction of apoptosis via death domain receptors; cell-cell signaling; phospholipase C activation; positive regulation of protein ubiquitination; small GTPase mediated signal transduction; Ras protein signal transduction; positive regulation of axonogenesis; negative regulation of neuron apoptosis; positive regulation of collateral sprouting; neurite morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
Disease: Neuropathy, Hereditary Sensory And Autonomic, Type V
Reference #:  P01138 (UniProtKB)
Alt. Names/Synonyms: Beta-nerve growth factor; Beta-NGF; HSAN5; MGC161426; MGC161428; nerve growth factor (beta polypeptide); nerve growth factor, beta polypeptide; nerve growth factor, beta subunit; NGF; NGFB
Gene Symbols: NGF
Molecular weight: 26,959 Da
Basal Isoelectric point: 9.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

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LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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