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NGF (human)

Overview NGF Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Homodimer. Belongs to the NGF-beta family. Note: This description may include information from UniProtKB. Protein type: Secreted; Secreted, signal peptide Cellular Component: extracellular space; endoplasmic reticulum lumen; Golgi lumen; extracellular region; endosome Molecular Function: nerve growth factor receptor binding; growth factor activity; receptor signaling protein activity Biological Process: response to nicotine; response to peptide hormone stimulus; activation of MAPKK activity; nerve growth factor receptor signaling pathway; adult locomotory behavior; apoptosis; positive regulation of axon extension; response to glucocorticoid stimulus; regulation of neurotransmitter secretion; response to lipopolysaccharide; regulation of axonogenesis; sensory perception of pain; negative regulation of cell cycle; nerve growth factor processing; response to radiation; small GTPase mediated signal transduction; positive regulation of cell proliferation; negative regulation of neuron apoptosis; inflammatory response; response to electrical stimulus; neurite development; response to drug; phosphoinositide-mediated signaling; positive regulation of protein amino acid autophosphorylation; memory; positive regulation of nerve growth factor receptor signaling pathway; peripheral nervous system development; response to mechanical stimulus; phospholipase C activation; Ras protein signal transduction; positive regulation of axonogenesis; positive regulation of transcription factor activity; transmembrane receptor protein tyrosine kinase signaling pathway Reference #:  P01138 (UniProtKB) Alt. Names/Synonyms: Beta-nerve growth factor; Beta-NGF; HSAN5; MGC161426; MGC161428; nerve growth factor (beta polypeptide); nerve growth factor, beta polypeptide; nerve growth factor, beta subunit; NGF; NGFB Gene Symbols: NGF Molecular weight: 26,959 Da Basal Isoelectric point: 9.94  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NGF 1BET - A=131-237 (mouse) 1BTG - A/C/B=130-239 (mouse) 1SGF - Y/B=122-239 (mouse) 3IJ2 - A/B=129-351 (mouse) 4EAX - A/D/C/B=122-241 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K155-a	TATDIKGkEVMVLGE

	mouse
K155	TATDIKGKEVTVLAE

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