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NHEJ1 (human)

Overview NHEJ1 DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary. Interacts with XRCC4 and the XRCC4-LIG4 complex. Binds DNA in a length-dependent manner. Ubiquitously expressed. Belongs to the XLF family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA repair Cellular Component: nucleus Molecular Function: protein binding; DNA binding Biological Process: central nervous system development; B cell differentiation; response to ionizing radiation; positive regulation of ligase activity; double-strand break repair via nonhomologous end joining; DNA recombination; T cell differentiation Reference #:  Q9H9Q4 (UniProtKB) Alt. Names/Synonyms: Cernunnos; FLJ12610; NHEJ1; Non-homologous end-joining factor 1; nonhomologous end-joining factor 1; Protein cernunnos; XLF; XRCC4-like factor Gene Symbols: NHEJ1 Molecular weight: 33,337 Da Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NHEJ1 2QM4 - A/D/C/B=1-233 (human) 2R9A - A/B=1-224 (human) 3Q4F - A/F/B/E=1-224 (human) 3RWR - S/O/T/W/X/E/H/Q/M/D/I/L=1-224 (human) 3SR2 - H/D/C/G=1-224 (human) 3W03 - A/B=1-233 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 2QM4 2R9A 3Q4F 3RWR 3SR2 3W03  |  Phospho3D  |  DISEASE 611290 611291  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		S55-p	QVDTSVVsQRAKELN
1	1		S132-p	LASPSLVsQHLIRPL
0	1		Y167	KDLEIQDYQESGATL
0	1		K180-u	TLIRDRLkTEPFEEN
1	1		S203-p	EKLPEACsIGDGKPF
0	1		T222	QDLYMAVTtQEVQVG
1	0		T223-p	DLYMAVTtQEVQVGQ
1	2		S245-p	PHTSNSAsLQGIDsQ
1	1		S251-p	AsLQGIDsQCVNQPE
0	1		S262-p	NQPEQLVssAPtLsA
1	2		S263-p	QPEQLVssAPtLsAP
1	2		T266-p	QLVssAPtLsAPEKE
0	1		S268-p	VssAPtLsAPEKEST

	mouse
S55	QVDTSVVSQRAKELN
S132	PASSSLVSQHLIHPL
Y167	KDLEIQAYQESGAVL
K180	VLSRSRLKTEPFEEN
A203	EKLPEACAVGDGKPF
T222-p	QSLYVAVtKQQIQAR
K223	SLYVAVtKQQIQARQ
S245-p	TQASSSTsPRGTDNQ
-	gap
S258	NQPEEPVSLSSTLSE
L259	QPEEPVSLSSTLSEP
T262	EPVSLSSTLSEPEYE
S264	VSLSSTLSEPEYEPV

	rat
S55	QVDTLEVSQRAKELN
S137	PASSLLVSQHLICPL
Y172-p	KDLEIQAyQESGAVL
K185	VLSRGRLKTEPFEEN
A208	EKLPEACAVGDGRPF
T227	QSLYVAVTKQQVQAR
K228	SLYVAVTKQQVQARQ
S250	PQTSSSTSPQGTDSQ
S256	TSPQGTDSQLQNQPE
S267	NQPEQQISPTPTLSE
P268	QPEQQISPTPTLSEP
T271	QQISPTPTLSEPECE
S273	ISPTPTLSEPECEPM

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