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Protein Page:
Sam68 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Sam68 a nuclear RNA-binding protein. May be involved in slicing and mRNA transport. Associates with src in mitosis. Binds to RNA via a heteronuclear ribonucleoprotein K homology domain. Exerts functionally separable effects on cell proliferation and survival, dependent on its ability to bind specifically to RNA. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein
Cellular Component: membrane; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; SH3/SH2 adaptor activity; DNA binding; RNA binding; protein complex binding; poly(U) binding; SH3 domain binding; poly(A) binding
Biological Process: positive regulation of translational initiation; cell proliferation; cell surface receptor linked signal transduction; transcription, DNA-dependent; positive regulation of signal transduction; positive regulation of RNA export from nucleus; regulation of protein stability; regulation of RNA export from nucleus; signal transduction; negative regulation of transcription, DNA-dependent; mRNA processing; G2/M transition of mitotic cell cycle; cell cycle arrest
Reference #:  Q07666 (UniProtKB)
Alt. Names/Synonyms: FLJ34027; GAP-associated tyrosine phosphoprotein p62; GAP-associated tyrosine phosphoprotein p62 (Sam68); KH domain containing, RNA binding, signal transduction associated 1; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KHDR1; KHDRBS1; p21 Ras GTPase-activating protein-associated p62; p62; p68; SAM68; Src-associated in mitosis 68 kDa protein
Gene Symbols: KHDRBS1
Molecular weight: 48,227 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Sam68

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 A9 QRRDDPAARMSRssG
0 1 S14-p PAARMSRssGRsGsM
0 2 S15-p AARMSRssGRsGsMD
0 12 S18-p MSRssGRsGsMDPSG
1 34 S20-p RssGRsGsMDPSGAH
0 3 S29-p DPSGAHPsVRQtPsR
0 7 T33-p AHPsVRQtPsRQPPL
0 1 S35-p PsVRQtPsRQPPLPH
0 2 R36 sVRQtPsRQPPLPHR
0 1 P38 RQtPsRQPPLPHRSr
0 1 R43 RQPPLPHRSrGGGGG
0 3 R45 PPLPHRSRGGGGGSr
1 0 R45-m2 PPLPHRSrGGGGGSr
0 2 R52 rGGGGGSRGGARAsP
1 0 R52-m2 rGGGGGSrGGARAsP
0 1 R56 GGSrGGARAsPAtQP
1 9 S58-p SrGGARAsPAtQPPP
0 5 T61-p GARAsPAtQPPPLLP
1 0 A71 PPLLPPSAtGPdAtV
0 1 T72-p PLLPPSAtGPdAtVG
0 2 D75-ca PPSAtGPdAtVGGPA
0 2 T77-p SAtGPdAtVGGPAPt
1 6 T84-p tVGGPAPtPLLPPSA
0 2 K96-ac PSATASVkMEPENky
1 0 K96-sm PSATASVkMEPENky
0 1 K102-sm VkMEPENkyLPELMA
0 1 K102 VkMEPENKyLPELMA
0 2 Y103-p kMEPENkyLPELMAE
0 1 S113-p ELMAEKDsLDPSFTH
0 1 S137-p EKIQKGDsKKDDEEN
0 1 S150-p ENYLDLFsHKNMKLK
0 1 K152 YLDLFsHKNMKLKER
0 3 K165-ac ERVLIPVkQYPkFNF
0 14 K165-ub ERVLIPVkQYPkFNF
0 1 K169-ac IPVkQYPkFNFVGkI
0 3 K169-ub IPVkQYPkFNFVGkI
0 3 K175-ac PkFNFVGkILGPQGN
0 3 K175-ub PkFNFVGkILGPQGN
0 1 T183-p ILGPQGNtIkRLQEE
0 3 K185-ub GPQGNtIkRLQEETG
0 1 K185-sc GPQGNtIkRLQEETG
0 1 K194 LQEETGAKIsVLGkG
0 1 K194-m1 LQEETGAkIsVLGkG
0 1 S196-p EETGAkIsVLGkGsM
0 1 K200-m1 AkIsVLGkGsMRDKA
0 1 S202-p IsVLGkGsMRDKAkE
0 6 K208-ac GsMRDKAkEEELRKG
0 9 K252-ac AHAMEEVkkFLVPDM
0 1 K253-ac HAMEEVkkFLVPDMM
0 10 R282-m1 NGVPEPSrGrGVPVr
0 7 R284-m1 VPEPSrGrGVPVrGr
0 4 R284-m2 VPEPSrGrGVPVrGr
0 7 R289-m2 rGrGVPVrGrGAAPP
0 1 R289-m1 rGrGVPVrGrGAAPP
0 8 R291-m2 rGVPVrGrGAAPPPP
0 1 R291-m1 rGVPVrGrGAAPPPP
0 7 R302-m2 PPPPPVPrGrGVGPP
0 1 R302-m1 PPPPPVPrGrGVGPP
0 3 R304-m1 PPPVPrGrGVGPPrG
1 1 R304-m2 PPPVPrGrGVGPPrG
1 2 R310-m1 GrGVGPPrGALVrGt
0 1 R310-m2 GrGVGPPrGALVrGt
1 1 R315-m1 PPrGALVrGtPVrGA
0 1 R315-m2 PPrGALVrGtPVrGA
0 2 T317-p rGALVrGtPVrGAIT
1 2 R320-m1 LVrGtPVrGAITrGA
0 1 R320-m2 LVrGtPVrGAITrGA
0 1 A322 rGtPVrGAITrGATV
1 11 R325-m1 PVrGAITrGATVTrG
0 1 R325-m2 PVrGAITrGATVTrG
0 5 R331-m1 TrGATVTrGVPPPPT
0 4 R331-m2 TrGATVTrGVPPPPT
0 2 R340-m1 VPPPPTVrGAPAPrA
0 1 R340 VPPPPTVRGAPAPrA
0 3 R346-m2 VrGAPAPrArTAGIQ
0 1 R346-m1 VrGAPAPrArTAGIQ
0 2 R348-m2 GAPAPrArTAGIQRI
0 1 R348-m1 GAPAPrArTAGIQRI
0 1 T365-p PPPPAPEtyEEyGyD
0 5 Y366-p PPPAPEtyEEyGyDD
0 5 Y369-p APEtyEEyGyDDtyA
0 3 Y371-p EtyEEyGyDDtyAEQ
0 2 T374-p EEyGyDDtyAEQSyE
0 3 Y375-p EyGyDDtyAEQSyEG
0 2 Y380-p DtyAEQSyEGYEGYy
0 1 Y387-p yEGYEGYysQsQGDS
0 1 S388-p EGYEGYysQsQGDSE
0 1 S390-p YEGYysQsQGDSEyy
0 10 Y396-p QsQGDSEyyDYGHGE
0 6 Y397-p sQGDSEyyDYGHGEV
0 6 Y408-p HGEVQDSyEAyGQDD
0 3 Y411-p VQDSyEAyGQDDWNG
0 3 K432-ub APPARPVkGAyREHP
1 40 Y435-p ARPVkGAyREHPyGR
1 15 Y440-p GAyREHPyGRy____
1 2 Y443-p REHPyGRy_______
  mouse

 
S9-p QRRDDPAsRLTRSSG
S14 PAsRLTRSSGRsCsK
S15 AsRLTRSSGRsCsKD
S18-p LTRSSGRsCsKDPSG
S20-p RSSGRsCsKDPSGAH
S29 DPSGAHPSVRLTPSr
T33 AHPSVRLTPSrPsPL
S35 PSVRLTPSrPsPLPH
R36-m1 SVRLTPSrPsPLPHr
S38-p RLTPSrPsPLPHrPr
R43-m1 rPsPLPHrPrGGGGG
R45-m1 sPLPHrPrGGGGGPr
R45 sPLPHrPRGGGGGPr
R52-m1 rGGGGGPrGGArAsP
R52 rGGGGGPRGGArAsP
R56-m1 GGPrGGArAsPAtQP
S58-p PrGGArAsPAtQPPP
T61-p GArAsPAtQPPPLLP
T71-p PPLLPPStPGPDATV
P72 PLLPPStPGPDATVV
D75 PPStPGPDATVVGSA
T77 StPGPDATVVGSAPt
T84-p TVVGSAPtPLLPPSA
K96 PSATAAVKMEPENkY
K96 PSATAAVKMEPENkY
K102 VKMEPENKYLPELMA
K102-ub VKMEPENkYLPELMA
Y103 KMEPENkYLPELMAE
S113 ELMAEKDSLDPSFTH
S137-p EKIQKGEsKKDDEEN
S150 ENYLDLFSHkNMKLK
K152-ub YLDLFSHkNMKLKER
K165 ERVLIPVKQYPkFNF
K165-ub ERVLIPVkQYPkFNF
K169 IPVkQYPKFNFVGkI
K169-ub IPVkQYPkFNFVGkI
K175 PkFNFVGKILGPQGN
K175-ub PkFNFVGkILGPQGN
T183 ILGPQGNTIkRLQEE
K185-ub GPQGNTIkRLQEETG
K185 GPQGNTIKRLQEETG
K194-ub LQEETGAkISVLGKG
K194 LQEETGAKISVLGKG
S196 EETGAkISVLGKGSM
K200 AkISVLGKGSMRDKA
S202 ISVLGKGSMRDKAKE
K208 GSMRDKAKEEELRKG
K252 AHAMEEVKKFLVPDM
K253 HAMEEVKKFLVPDMM
R282-m1 NGVPEPSrGrGVSVr
R284-m1 VPEPSrGrGVSVrGr
R284-m2 VPEPSrGrGVSVrGr
R289-m2 rGrGVSVrGrGAAPP
R289 rGrGVSVRGrGAAPP
R291-m2 rGVSVrGrGAAPPPP
R291-m1 rGVSVrGrGAAPPPP
R302-m2 PPPPPVPrGrGVGPP
R302 PPPPPVPRGrGVGPP
R304-m1 PPPVPrGrGVGPPrG
R304-m2 PPPVPrGrGVGPPrG
R310-m1 GrGVGPPrGALVrGt
R310-m2 GrGVGPPrGALVrGt
R315-m1 PPrGALVrGtPVrGs
R315-m2 PPrGALVrGtPVrGs
T317-p rGALVrGtPVrGsIT
R320-m1 LVrGtPVrGsITrGA
R320-m2 LVrGtPVrGsITrGA
S322-p rGtPVrGsITrGATV
R325-m1 PVrGsITrGATVTrG
R325-m2 PVrGsITrGATVTrG
R331-m1 TrGATVTrGVPPPPT
R331-m2 TrGATVTrGVPPPPT
R340-m1 VPPPPTVrGAPTPrA
R340-m2 VPPPPTVrGAPTPrA
R346-m2 VrGAPTPrArTAGIQ
R346 VrGAPTPRArTAGIQ
R348-m2 GAPTPrArTAGIQRI
R348 GAPTPrARTAGIQRI
T365 PPTPAPETYEDYGYD
Y366 PTPAPETYEDYGYDD
Y369 APETYEDYGYDDTYA
Y371 ETYEDYGYDDTYAEQ
T374 EDYGYDDTYAEQSYE
Y375 DYGYDDTYAEQSYEG
Y380 DTYAEQSYEGYEGYY
Y387 YEGYEGYYSQSQGES
S388 EGYEGYYSQSQGESE
S390 YEGYYSQSQGESEyy
Y396-p QSQGESEyyDYGHGE
Y397-p SQGESEyyDYGHGEL
Y408 HGELQDSYEAYGQDD
Y411 LQDSYEAYGQDDWNG
K432-ub APPARPVkGAyREHP
Y435-p ARPVkGAyREHPyGR
Y440-p GAyREHPyGRy____
Y443-p REHPyGRy_______
  rat

 
A9 QRRDDPAARLTRSSG
S14 PAARLTRSSGRSCSK
S15 AARLTRSSGRSCSKD
S18 LTRSSGRSCSKDPSG
S20 RSSGRSCSKDPSGAH
S29 DPSGAHPSVRLTPSR
T33 AHPSVRLTPSRPsPL
S35 PSVRLTPSRPsPLPH
R36 SVRLTPSRPsPLPHR
S38-p RLTPSRPsPLPHRSR
R43 RPsPLPHRSRGGGGG
R45 sPLPHRSRGGGGGPR
R45 sPLPHRSRGGGGGPR
R52 RGGGGGPRGGARASP
R52 RGGGGGPRGGARASP
R56 GGPRGGARASPATQP
S58 PRGGARASPATQPPP
T61 GARASPATQPPPLLP
N71 PPLLPPSNPGPDATV
P72 PLLPPSNPGPDATVV
D75 PPSNPGPDATVVGSA
T77 SNPGPDATVVGSAPT
T84 TVVGSAPTPLLPPSA
K96-ac PSATAAAkMEPENKY
K96 PSATAAAKMEPENKY
K102 AkMEPENKYLPELMA
K102 AkMEPENKYLPELMA
Y103 kMEPENKYLPELMAE
S113 ELMAEKDSLDPSFTH
S137 EKIQKGESKKDDEEN
S150 ENYLDLFSHKNMKLK
K152 YLDLFSHKNMKLKER
K165-ac ERVLIPVkQYPkFNF
K165 ERVLIPVKQYPkFNF
K169-ac IPVkQYPkFNFVGkI
K169 IPVkQYPKFNFVGkI
K175-ac PkFNFVGkILGPQGN
K175 PkFNFVGKILGPQGN
T183 ILGPQGNTIKRLQEE
K185 GPQGNTIKRLQEETG
K185 GPQGNTIKRLQEETG
K194 LQEETGAKISVLGKG
K194 LQEETGAKISVLGKG
S196 EETGAKISVLGKGSM
K200 AKISVLGKGSMRDKA
S202 ISVLGKGSMRDKAKE
K208 GSMRDKAKEEELRKG
K252 AHAMEEVKKFLVPDM
K253 HAMEEVKKFLVPDMM
R282 NGVPEPSRGRGVSVR
R284 VPEPSRGRGVSVRGR
R284 VPEPSRGRGVSVRGR
R289 RGRGVSVRGRGAAPP
R289 RGRGVSVRGRGAAPP
R291 RGVSVRGRGAAPPPP
R291 RGVSVRGRGAAPPPP
R302 PPPPPVPRGRGVGPP
R302 PPPPPVPRGRGVGPP
R304 PPPVPRGRGVGPPRG
R304 PPPVPRGRGVGPPRG
R310 GRGVGPPRGALVRGT
R310 GRGVGPPRGALVRGT
R315 PPRGALVRGTPVRGS
R315 PPRGALVRGTPVRGS
T317 RGALVRGTPVRGSIT
R320 LVRGTPVRGSITrGA
R320 LVRGTPVRGSITrGA
S322 RGTPVRGSITrGATV
R325-m1 PVRGSITrGATVTrG
R325 PVRGSITRGATVTrG
R331-m1 TrGATVTrGVPPPPT
R331 TrGATVTRGVPPPPT
R340 VPPPPTVRGAPTPRA
R340 VPPPPTVRGAPTPRA
R346 VRGAPTPRARTAGIQ
R346 VRGAPTPRARTAGIQ
R348 GAPTPRARTAGIQRI
R348 GAPTPRARTAGIQRI
T365 PPTPAPETYEDYGYD
Y366 PTPAPETYEDYGYDD
Y369 APETYEDYGYDDSYA
Y371 ETYEDYGYDDSYAEQ
S374 EDYGYDDSYAEQSYE
Y375 DYGYDDSYAEQSYEG
Y380 DSYAEQSYEGYEGYY
Y387 YEGYEGYYSQSQGES
S388 EGYEGYYSQSQGESE
S390 YEGYYSQSQGESEYY
Y396 QSQGESEYYDYGHGE
Y397 SQGESEYYDYGHGEL
Y408 HGELQDSYEAYGQDD
Y411 LQDSYEAYGQDDWNG
K432 APPARPVKGAYREHP
Y435 ARPVKGAYREHPYGR
Y440 GAYREHPYGRY____
Y443 REHPYGRY_______
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