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Protein Page:
MyoD (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MyoD a transcription factor of the basic helix-loop-helix family and the myogenic factors subfamily. Involved in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. It is involved in muscle cell differentiation, and is essential for repair of damaged tissue. It activates its own transcription which may stabilize commitment to myogenesis. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; RNA splicing; DNA binding protein
Cellular Component: nucleoplasm; transcription factor complex; myofibril; nuclear chromatin; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; protein heterodimerization activity; chromatin DNA binding; ubiquitin protein ligase binding; transcription coactivator activity; transcription factor binding; nuclear hormone receptor binding
Biological Process: transcription from RNA polymerase II promoter; muscle development; skeletal muscle development; skeletal muscle fiber adaptation; positive regulation of skeletal muscle regeneration; regulation of RNA splicing; myotube differentiation involved in skeletal muscle regeneration; muscle cell fate commitment; myotube cell development; skeletal muscle fiber development; cellular response to starvation; protein amino acid phosphorylation; regulation of transcription from RNA polymerase II promoter; muscle cell differentiation; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; myoblast cell fate determination; regulation of alternative nuclear mRNA splicing, via spliceosome
Reference #:  P15172 (UniProtKB)
Alt. Names/Synonyms: BHLHC1; Class C basic helix-loop-helix protein 1; Myf-3; MYF3; Myoblast determination protein 1; MYOD; MYOD1; myogenic differentiation 1; Myogenic factor 3; PUM
Gene Symbols: MYOD1
Molecular weight: 34,501 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MyoD

Protein Structure Not Found.


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Sites Implicated In
activity, inhibited: T115‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 S5 ___MELLSPPLRDVD
2 0 Y30 FATTDDFYDDPCFDS
1 0 K58-ac MHVGALLkPEEHSHF
3 0 K99-ac RCLLWACkACkRkTT
3 1 K102-ac LWACkACkRkTTNAD
1 0 K104-ac ACkACkRkTTNADRR
2 0 T115-p ADRRKAAtMRERRRL
1 0 K133 NEAFETLKRCTSSNP
1 1 Y156 ILRNAIRYIEGLQAL
6 0 S200 YSGDSDASSPRsNCs
0 3 S204-p SDASSPRsNCsDGMM
0 2 S207-p SSPRsNCsDGMMDys
1 2 Y213-p CsDGMMDysGPPSGA
0 2 S214-p sDGMMDysGPPSGAR
1 0 P238 YNEAPSEPRPGKSAA
  mouse

 
S5-p ___MELLsPPLRDID
Y30-p FETADDFyDDPCFDS
K58 VHMGALLKPEEHAHF
K99-ac RCLLWACkACkRKTT
K102-ac LWACkACkRKTTNAD
K104 ACkACkRKTTNADRR
T115-p ADRRKAAtMRERRRL
K133-ub NEAFETLkRCTSSNP
Y156-p ILRNAIRyIEGLQAL
S200-p SGDSDASsPRsNCSD
S203-p SDASsPRsNCSDGMM
S206 SsPRsNCSDGMMDyS
Y212-p CSDGMMDySGPPSGP
S213 SDGMMDySGPPSGPR
S237-p YSEAAREsRPGKSAA
  rat

 
S5 ___MELLSPPLRDTD
Y30 FATRDDFYDDPCFDS
K58 VHVGALLKPEEHAHF
K99 RCLLWACKACKRKTT
K102 LWACKACKRKTTNAD
K104 ACKACKRKTTNADRR
T115 ADRRKAATMRERRRL
K133 NEAFETLKRCTSSNP
Y156 ILRNAIRYIEGLQAL
S200 SGDSDASSPRSNCSD
S203 SDASSPRSNCSDGMM
S206 SSPRSNCSDGMMDYS
Y212 CSDGMMDYSGPPSGP
S213 SDGMMDYSGPPSGPR
P237 YSEASSEPRPGKSAA
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