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Protein Page:
syndecan-4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
syndecan-4 a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Expressed as a homodimer. Promotes cell spreading in a beta(1) integrin-dependent fashion through PKC-alpha and Rho. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis
Cellular Component: lysosomal lumen; costamere; focal adhesion; cell surface; integral to plasma membrane; Golgi lumen; plasma membrane; lipid raft
Molecular Function: protein binding; protein kinase C binding; fibronectin binding; cytoskeletal protein binding
Biological Process: chondroitin sulfate metabolic process; phototransduction, visible light; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; extracellular matrix organization and biogenesis; glycosaminoglycan metabolic process; positive regulation of focal adhesion formation; ureteric bud development; positive regulation of protein kinase activity; positive regulation of stress fiber formation; carbohydrate metabolic process; retinoid metabolic process
Reference #:  P31431 (UniProtKB)
Alt. Names/Synonyms: Amphiglycan; MGC22217; ryudocan amphiglycan; Ryudocan core protein; SDC4; SYND4; syndecan 4; syndecan 4 (amphiglycan, ryudocan); syndecan proteoglycan 4; Syndecan-4
Gene Symbols: SDC4
Molecular weight: 21,642 Da
Basal Isoelectric point: 4.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

syndecan-4

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: S179‑p
cell cycle regulation: S179‑p
cytoskeletal reorganization: S179‑p
intracellular localization: S179‑p
molecular association, regulation: S179‑p
protein processing: S179‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S97-ga PERAGSGsQVPtEPK
0 1 T101-ga GSGsQVPtEPKKLEE
0 1 S117-ga EVIPKRIsPVEESED
0 1 S126-ga VEESEDVsNKVSMSS
0 1 T134-p NKVSMSStVQGSNIF
8 0 S179-p MKKKDEGsyDLGKKP
1 11 Y180-p KKKDEGsyDLGKKPI
0 1 K190-ub GKKPIYKkAPtNEFy
0 1 T193-p PIYKkAPtNEFyA__
1 288 Y197-p kAPtNEFyA______
  mouse

 
I98 PENAQPGIRVPSEPK
S102 QPGIRVPSEPKELEE
- under review  
S126 SDVGDDMSNKVSMSS
T134 NKVSMSSTAQGSNIF
S179-p MKKKDEGsYDLGKKP
Y180 KKKDEGsYDLGKKPI
K190 GKKPIYKKAPTNEFy
T193 PIYKKAPTNEFyA__
Y197-p KAPTNEFyA______
  rat

 
I101 PENAQPGIRVPSEPK
S105 QPGIRVPSEPKELEE
- under review  
S130 DVGDDDVSNKVSMSS
T138 NKVSMSSTSQGSNIF
S183-p MKKKDEGsYDLGKKP
Y184 KKKDEGsYDLGKKPI
K194 GKKPIYKKAPTNEFy
T197 PIYKKAPTNEFyA__
Y201-p KAPTNEFyA______
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