a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Expressed as a homodimer. Promotes cell spreading in a beta(1) integrin-dependent fashion through PKC-alpha and Rho. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 20q12
Cellular Component: lysosomal lumen; cell surface; costamere; focal adhesion; integral to plasma membrane; Golgi lumen; plasma membrane; lipid raft
Molecular Function: protein binding; protein kinase C binding; fibronectin binding; cytoskeletal protein binding
Biological Process: chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; phototransduction, visible light; glycosaminoglycan catabolic process; extracellular matrix organization and biogenesis; positive regulation of focal adhesion formation; glycosaminoglycan metabolic process; ureteric bud development; positive regulation of protein kinase activity; positive regulation of stress fiber formation; carbohydrate metabolic process; retinoid metabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.