a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Expressed as a homodimer. Promotes cell spreading in a beta(1) integrin-dependent fashion through PKC-alpha and Rho. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 20q12
Cellular Component: lysosomal lumen; focal adhesion; cell surface; costamere; Golgi lumen; integral to plasma membrane; plasma membrane; lipid raft
Molecular Function: protein binding; protein kinase C binding; fibronectin binding; cytoskeletal protein binding
Biological Process: chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; phototransduction, visible light; glycosaminoglycan catabolic process; extracellular matrix organization and biogenesis; positive regulation of focal adhesion formation; glycosaminoglycan metabolic process; ureteric bud development; positive regulation of protein kinase activity; carbohydrate metabolic process; positive regulation of stress fiber formation; retinoid metabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.