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syndecan-4 (human)

Overview syndecan-4 a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Expressed as a homodimer. Promotes cell spreading in a beta(1) integrin-dependent fashion through PKC-alpha and Rho. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion Cellular Component: lysosomal lumen; cell surface; costamere; focal adhesion; Golgi lumen; integral to plasma membrane; plasma membrane; extracellular region; lipid raft Molecular Function: protein binding; protein kinase C binding; fibronectin binding; cytoskeletal protein binding Biological Process: chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; positive regulation of focal adhesion formation; ureteric bud development; positive regulation of protein kinase activity; positive regulation of stress fiber formation; carbohydrate metabolic process Reference #:  P31431 (UniProtKB) Alt. Names/Synonyms: Amphiglycan; MGC22217; ryudocan amphiglycan; Ryudocan core protein; SDC4; SYND4; syndecan 4; syndecan 4 (amphiglycan, ryudocan); syndecan proteoglycan 4; Syndecan-4 Gene Symbols: SDC4 Molecular weight: 21,642 Da Basal Isoelectric point: 4.39  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below syndecan-4 1EJP - A/B=171-198 (human) 1EJQ - A/B=171-198 (human) 1OBY - P/Q=193-198 (human) 1YBO - C/D=182-198 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1EJP 1EJQ 1OBY 1YBO  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell adhesion, altered: S179‑p cell cycle regulation: S179‑p cytoskeletal reorganization: S179‑p intracellular localization: S179‑p molecular association, regulation: S179‑p protein processing: S179‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T134-p	NKVSMSStVQGSNIF
8	0		S179-p	MKKKDEGsyDLGKKP
1	10		Y180-p	KKKDEGsyDLGKKPI
0	1		K190-u	GKKPIYKkAPTNEFy
1	262		Y197-p	kAPTNEFyA______

	mouse
T134	NKVSMSSTAQGSNIF
S179-p	MKKKDEGsYDLGKKP
Y180	KKKDEGsYDLGKKPI
K190	GKKPIYKKAPTNEFy
Y197-p	KAPTNEFyA______

	rat
T138	NKVSMSSTSQGSNIF
S183-p	MKKKDEGsYDLGKKP
Y184	KKKDEGsYDLGKKPI
K194	GKKPIYKKAPTNEFy
Y201-p	KAPTNEFyA______

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