Home

CaR (human)

Overview CaR a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Receptor, GPCR; GPCR, family 3; Membrane protein, integral; Motility/polarity/chemotaxis Cellular Component: integral to plasma membrane; plasma membrane Molecular Function: G-protein coupled receptor activity; protein binding; phosphoinositide phospholipase C activity Biological Process: cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; ossification; anatomical structure morphogenesis; chemosensory behavior; detection of calcium ion Reference #:  P41180 (UniProtKB) Alt. Names/Synonyms: calcium-sensing receptor; CAR; CASR; EIG8; Extracellular calcium-sensing receptor; FHH; FIH; GPRC2A; HHC; HHC1; MGC138441; NSHPT; parathyroid Ca(2+)-sensing receptor 1; Parathyroid cell calcium-sensing receptor; PCAR1 Gene Symbols: CASR Molecular weight: 120,674 Da Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states

Select Structure to View Below CaR

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 145980 146200 239200 601198 601199 612899  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
activation: T888‑p, S895‑p, S915‑p inhibition: T888‑p intracellular localization: S899‑p molecular association, regulation: S899‑p phosphorylation: T888‑p receptor desensitization, altered: T888‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		R62	PESVECIRYNFRGFR
0	1		T186-p	QFKSFLRtIPNDEHQ
0	1		T195-p	PNDEHQAtAMADIIE
0	1		K336-a	GFREFLKkVHPRKsV
0	1		S342-p	KkVHPRKsVHNGFAK
0	1		S875	TIEEVRCSTAAHAFK
0	1		T876	IEEVRCSTAAHAFKV
0	1		K882	STAAHAFKVAARAtL
6	1		T888-p	FKVAARAtLRRsNVs
1	1		S892-p	ARAtLRRsNVsRKRs
1	0		S895-p	tLRRsNVsRKRssSL
1	1		S899-p	sNVsRKRssSLGGSt
0	1		S900-p	NVsRKRssSLGGStG
0	1		T906-p	ssSLGGStGSTPSSS
1	0		S915-p	STPSSSIsSKSNSED
0	1		S920	SIsSKSNSEDPFPQP
0	1		S992	NAMAHRNSTHQNSLE
0	1		S997	RNSTHQNSLEAQKSS
0	1		S1061	LVVSSSQSFVISGGG

	mouse
R62-m2	PESVECIrYNFRGFR
T186	QFKSFLRTIPNDEHQ
T195	PNDEHQATAMADIIE
K336	GFREFLQKVHPRKSV
S342	QKVHPRKSVHNGFAK
S875-p	TIEEVRSstAAHAFk
T876-p	IEEVRSstAAHAFkV
K882-u	stAAHAFkVAARATL
T888	FkVAARATLRRPNIS
P892	ARATLRRPNISRKRS
S895	TLRRPNISRKRSSSL
S899	PNISRKRSSSLGGST
S900	NISRKRSSSLGGSTG
T906	SSSLGGSTGSIPSSS
S915	SIPSSSISSKSNsED
S920-p	SISSKSNsEDRFPQP
S993-p	NAMAHRNsMRQNsLE
S998-p	RNsMRQNsLEAQKSN
S1062-p	LVMSTSRsFVISGGG

	rat
R62	PESVECIRYNFRGFR
T186	QYKSFLRTIPNDEHQ
T195	PNDEHQATAMADIIE
K336	GFREFLQKVHPRKSV
S342	QKVHPRKSVHNGFAK
S875	TIEEVRSSTAAHAFK
T876	IEEVRSSTAAHAFKV
K882	STAAHAFKVAARATL
T888	FKVAARATLRRPNIS
P892	ARATLRRPNISRKRS
S895	TLRRPNISRKRSSSL
S899	PNISRKRSSSLGGST
S900	NISRKRSSSLGGSTG
T906	SSSLGGSTGSIPSSS
S915	SIPSSSISSKSNSED
S920	SISSKSNSEDRFPQP
S993	NAMAHRNSMRQNSLE
S998	RNSMRQNSLEAQRSN
S1062	LVMSTSRSFVISGGG

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.