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Protein Page:
CaR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CaR a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, integral; GPCR, family 3; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3q13
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; protein binding; phosphoinositide phospholipase C activity
Biological Process: cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; anatomical structure morphogenesis; ossification; metabolic process; chemosensory behavior; detection of calcium ion
Reference #:  P41180 (UniProtKB)
Alt. Names/Synonyms: calcium-sensing receptor; CAR; CASR; EIG8; Extracellular calcium-sensing receptor; FHH; FIH; GPRC2A; HHC; HHC1; MGC138441; NSHPT; parathyroid Ca(2+)-sensing receptor 1; Parathyroid cell calcium-sensing receptor; PCAR1
Gene Symbols: CASR
Molecular weight: 120,674 Da
Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states
Select Structure to View Below

CaR

Protein Structure Not Found.


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Sites Implicated In
activity, induced: T888‑p, S895‑p, S915‑p
activity, inhibited: T888‑p
intracellular localization: S899‑p
molecular association, regulation: S899‑p
phosphorylation: T888‑p
receptor desensitization, altered: T888‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R62 PESVECIRYNFRGFR
0 1 T186-p QFKSFLRtIPNDEHQ
0 1 T195-p PNDEHQAtAMADIIE
0 1 K336-ac GFREFLKkVHPRKsV
0 1 S342-p KkVHPRKsVHNGFAK
0 1 S875 TIEEVRCSTAAHAFK
0 1 T876 IEEVRCSTAAHAFKV
0 1 K882 STAAHAFKVAARAtL
7 1 T888-p FKVAARAtLRRsNVs
1 1 S892-p ARAtLRRsNVsRKRs
1 0 S895-p tLRRsNVsRKRssSL
1 1 S899-p sNVsRKRssSLGGSt
0 1 S900-p NVsRKRssSLGGStG
0 1 T906-p ssSLGGStGSTPSSS
1 0 S915-p STPSSSIsSKSNSED
0 1 S918 SSSIsSKSNSEDPFP
0 2 S920 SIsSKSNSEDPFPQP
0 1 S992 NAMAHRNSTHQNSLE
0 1 S997 RNSTHQNSLEAQKSS
0 1 S1061 LVVSSSQSFVISGGG
  mouse

 
R62-m2 PESVECIrYNFRGFR
T186 QFKSFLRTIPNDEHQ
T195 PNDEHQATAMADIIE
K336 GFREFLQKVHPRKSV
S342 QKVHPRKSVHNGFAK
S875-p TIEEVRSstAAHAFk
T876-p IEEVRSstAAHAFkV
K882-ub stAAHAFkVAARATL
T888 FkVAARATLRRPNIS
P892 ARATLRRPNISRKRS
S895 TLRRPNISRKRSSSL
S899 PNISRKRSSSLGGST
S900 NISRKRSSSLGGSTG
T906 SSSLGGSTGSIPSSS
S915 SIPSSSISSKSNsED
S918 SSSISSKSNsEDRFP
S920-p SISSKSNsEDRFPQP
S993-p NAMAHRNsMRQNsLE
S998-p RNsMRQNsLEAQKSN
S1062-p LVMSTSRsFVISGGG
  rat

 
R62 PESVECIRYNFRGFR
T186 QYKSFLRTIPNDEHQ
T195 PNDEHQATAMADIIE
K336 GFREFLQKVHPRKSV
S342 QKVHPRKSVHNGFAK
S875 TIEEVRSSTAAHAFK
T876 IEEVRSSTAAHAFKV
K882 STAAHAFKVAARATL
T888 FKVAARATLRRPNIS
P892 ARATLRRPNISRKRS
S895 TLRRPNISRKRSSSL
S899 PNISRKRSSSLGGST
S900 NISRKRSSSLGGSTG
T906 SSSLGGSTGSIPSSS
S915 SIPSSSISSKsNsED
S918-p SSSISSKsNsEDRFP
S920-p SISSKsNsEDRFPQP
S993 NAMAHRNSMRQNSLE
S998 RNSMRQNSLEAQRSN
S1062 LVMSTSRSFVISGGG
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