a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. Causes the formation of thin, actin-rich surface projections called filopodia. The oncoprotein Dbl specifically catalyzes the dissociation of GDP from this protein. Regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Interacts with DOCK9 which activates it by exchanging GDP for GTP. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. Interacts with CDC42EP4.Alternative splicing of this gene results in at least two transcript variants. Note: This description may include information from UniProtKB.
Protein type: G protein; Motility/polarity/chemotaxis; G protein, monomeric, Rho; G protein, monomeric
Molecular Function: GTPase activity; identical protein binding; protein binding; GTP binding; GTP-dependent protein binding; thioesterase binding; mitogen-activated protein kinase kinase kinase binding; apolipoprotein A-I receptor binding; protein kinase binding
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; axon guidance; regulation of protein heterodimerization activity; macrophage differentiation; filopodium formation; establishment and/or maintenance of cell polarity; positive regulation of JNK cascade; regulation of protein stability; regulation of filopodium formation; Wnt receptor signaling pathway through beta-catenin; substantia nigra development; GTP catabolic process; establishment of Golgi localization; small GTPase mediated signal transduction; keratinization; positive regulation of neuron apoptosis; regulation of mitosis; Golgi organization and biogenesis; epidermal growth factor receptor signaling pathway; positive regulation of cytokinesis; neuron fate determination; actin filament bundle formation; regulation of attachment of spindle microtubules to kinetochore; hair follicle morphogenesis; multicellular organism growth; positive regulation of phosphoinositide 3-kinase activity; establishment and/or maintenance of apical/basal cell polarity; positive regulation of metalloenzyme activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of synapse structural plasticity; regulation of small GTPase mediated signal transduction; muscle cell differentiation; positive regulation of pseudopodium formation; heart contraction; T cell costimulation; innate immune response; positive regulation of muscle cell differentiation; regulation of protein catabolic process; sprouting angiogenesis; actin cytoskeleton organization and biogenesis; blood coagulation; regulation of protein kinase activity; negative regulation of protein complex assembly; nuclear migration; positive regulation of DNA replication
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.