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Protein Page:
CDC42 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDC42 a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. Causes the formation of thin, actin-rich surface projections called filopodia. The oncoprotein Dbl specifically catalyzes the dissociation of GDP from this protein. Regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Interacts with DOCK9 which activates it by exchanging GDP for GTP. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. Interacts with CDC42EP4.Alternative splicing of this gene results in at least two transcript variants. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Cellular Component: Golgi membrane; neuron projection; membrane; cell soma; apical part of cell; cytoplasm; plasma membrane; microtubule organizing center; spindle midzone; midbody; cytosol; secretory granule; filopodium
Molecular Function: GTPase activity; identical protein binding; protein binding; GTP binding; GTP-dependent protein binding; thioesterase binding; mitogen-activated protein kinase kinase kinase binding; apolipoprotein A-I receptor binding; protein kinase binding
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; axon guidance; regulation of protein heterodimerization activity; filopodium formation; macrophage differentiation; establishment and/or maintenance of cell polarity; regulation of protein stability; positive regulation of JNK cascade; regulation of filopodium formation; Wnt receptor signaling pathway through beta-catenin; substantia nigra development; GTP catabolic process; establishment of Golgi localization; keratinization; positive regulation of neuron apoptosis; small GTPase mediated signal transduction; regulation of mitosis; Golgi organization and biogenesis; neuron fate determination; positive regulation of cytokinesis; epidermal growth factor receptor signaling pathway; actin filament bundle formation; regulation of attachment of spindle microtubules to kinetochore; hair follicle morphogenesis; multicellular organism growth; positive regulation of phosphoinositide 3-kinase activity; establishment and/or maintenance of apical/basal cell polarity; positive regulation of metalloenzyme activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of synapse structural plasticity; muscle cell differentiation; regulation of small GTPase mediated signal transduction; positive regulation of pseudopodium formation; heart contraction; T cell costimulation; positive regulation of muscle cell differentiation; innate immune response; regulation of protein catabolic process; sprouting angiogenesis; actin cytoskeleton organization and biogenesis; regulation of protein kinase activity; blood coagulation; negative regulation of protein complex assembly; nuclear migration; positive regulation of DNA replication
Reference #:  P60953 (UniProtKB)
Alt. Names/Synonyms: CDC42; CDC42Hs; Cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein, 25kDa); dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)); G25K; G25K GTP-binding protein; growth-regulating protein; GTP-binding protein, 25kD; small GTP binding protein CDC42
Gene Symbols: CDC42
Molecular weight: 21,259 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-├č Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDC42

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T17 GDGAVGKTCLLISYT
0 1 S22 GKTCLLISYTTNKFP
0 1 Y23 KTCLLISYTTNKFPs
0 1 T24 TCLLISYTTNKFPsE
0 1 T25 CLLISYTTNKFPsEy
0 2 S30-p YTTNKFPsEyVPTVF
0 4 Y32-p TNKFPsEyVPTVFDN
1 0 Y32 TNKFPsEYVPTVFDN
0 3 T35 FPsEyVPTVFDNYAV
0 1 Y40 VPTVFDNYAVTVMIG
0 1 T43 VFDNYAVTVMIGGEP
0 1 Y51 VMIGGEPYTLGLFDT
0 1 T52 MIGGEPYTLGLFDTA
0 1 T58 YTLGLFDTAGQEDyD
1 30 Y64-p DTAGQEDyDRLRPLS
1 0 S71 yDRLRPLSYPQTDVF
0 1 S88 CFSVVSPSSFENVKE
0 1 S89 FSVVSPSSFENVKEK
0 1 K96 SFENVKEKWVPEITH
0 14 K107 EITHHCPKTPFLLVG
0 2 K128 DDPSTIEKLAKNKQK
0 21 K133 IEKLAKNKQKPITPE
0 1 K135 KLAKNKQKPITPEtA
0 5 K135 KLAKNKQKPITPEtA
0 2 T141-p QKPITPEtAEKLARD
0 1 K144 ITPEtAEKLARDLKA
0 7 K144 ITPEtAEKLARDLKA
0 2 K153-ac ARDLKAVkYVECSAL
0 9 K153-ub ARDLKAVkYVECSAL
0 1 Y154 RDLKAVkYVECSALT
0 17 K163-ub ECSALTQkGLkNVFD
0 7 K166-ub ALTQkGLkNVFDEAI
0 1 - gap
0 1 - gap
0 21 K183-ub ALEPPEPkkSRRCVL
0 13 K184-ub LEPPEPkkSRRCVLL
  CDC42 iso1  
T17 GDGAVGKTCLLISYT
S22 GKTCLLISYTTNKFP
Y23 KTCLLISYTTNKFPS
T24 TCLLISYTTNKFPSE
T25 CLLISYTTNKFPSEy
S30 YTTNKFPSEyVPtVF
Y32-p TNKFPSEyVPtVFDN
Y32-ad TNKFPSEyVPtVFDN
T35-p FPSEyVPtVFDNYAV
Y40 VPtVFDNYAVTVMIG
T43 VFDNYAVTVMIGGEP
Y51 VMIGGEPYTLGLFDT
T52 MIGGEPYTLGLFDTA
T58 YTLGLFDTAGQEDyD
Y64-p DTAGQEDyDRLRPLS
S71 yDRLRPLSYPQTDVF
S88 CFSVVSPSSFENVKE
S89 FSVVSPSSFENVKEK
K96 SFENVKEKWVPEITH
K107-ub EITHHCPkTPFLLVG
K128-ub DDPSTIEkLAKNkQk
K133-ub IEkLAKNkQkPITPE
K135-ac kLAKNkQkPITPETA
K135-ub kLAKNkQkPITPETA
T141 QkPITPETAEkLARD
K144-ac ITPETAEkLARDLKA
K144-ub ITPETAEkLARDLKA
K153 ARDLKAVKyVECSAL
K153 ARDLKAVKyVECSAL
Y154-p RDLKAVKyVECSALT
R163 ECSALTQRGLKNVFD
K166 ALTQRGLKNVFDEAI
T182-p AALEPPEtQPKRKCC
K185 EPPEtQPKRKCCIF_
- gap
- gap
  mouse

► Hide Isoforms
 
T17-p GDGAVGKtCLLIsyt
S22-p GKtCLLIsyttNKFP
Y23-p KtCLLIsyttNKFPs
T24-p tCLLIsyttNKFPsE
T25-p CLLIsyttNKFPsEy
S30-p yttNKFPsEyVPtVF
Y32-p tNKFPsEyVPtVFDN
Y32 tNKFPsEYVPtVFDN
T35-p FPsEyVPtVFDNyAV
Y40-p VPtVFDNyAVtVMIG
T43-p VFDNyAVtVMIGGEP
Y51-p VMIGGEPytLGLFDt
T52-p MIGGEPytLGLFDtA
T58-p ytLGLFDtAGQEDyD
Y64-p DtAGQEDyDRLRPLS
S71 yDRLRPLSYPQTDVF
S88-p CFSVVSPssFENVKE
S89-p FSVVSPssFENVKEk
K96-ub sFENVKEkWVPEITH
K107 EITHHCPKTPFLLVG
K128-ub DDPSTIEkLAKNkQk
K133-ub IEkLAKNkQkPITPE
K135 kLAKNkQKPITPEtA
K135-ub kLAKNkQkPITPEtA
T141-p QkPITPEtAEkLARD
K144 ITPEtAEKLARDLKA
K144-ub ITPEtAEkLARDLKA
K153 ARDLKAVKYVECSAL
K153-ub ARDLKAVkYVECSAL
Y154 RDLKAVkYVECSALT
K163-ub ECSALTQkGLKNVFD
K166 ALTQkGLKNVFDEAI
- gap
- gap
K183-ub ALEPPEPkkSRRCVL
K184-ub LEPPEPkkSRRCVLL
  CDC42 iso1  
T17 GDGAVGKTCLLISYT
S22 GKTCLLISYTTNKFP
Y23 KTCLLISYTTNKFPS
T24 TCLLISYTTNKFPSE
T25 CLLISYTTNKFPSEY
S30 YTTNKFPSEYVPTVF
Y32 TNKFPSEYVPTVFDN
Y32 TNKFPSEYVPTVFDN
T35 FPSEYVPTVFDNYAV
Y40 VPTVFDNYAVTVMIG
T43 VFDNYAVTVMIGGEP
Y51 VMIGGEPYTLGLFDT
T52 MIGGEPYTLGLFDTA
T58 YTLGLFDTAGQEDYD
Y64 DTAGQEDYDRLRPLS
S71 YDRLRPLSYPQTDVF
S88 CFSVVSPSSFENVKE
S89 FSVVSPSSFENVKEK
K96 SFENVKEKWVPEITH
K107-ub EITHHCPkTPFLLVG
K128 DDPSTIEKLAKNkQK
K133-ub IEKLAKNkQKPITPE
K135 KLAKNkQKPITPETA
K135 KLAKNkQKPITPETA
T141 QKPITPETAEkLARD
K144 ITPETAEKLARDLKA
K144-ub ITPETAEkLARDLKA
K153 ARDLKAVKYVECSAL
K153-ub ARDLKAVkYVECSAL
Y154 RDLKAVkYVECSALT
R163 ECSALTQRGLKNVFD
K166 ALTQRGLKNVFDEAI
T182 AALEPPETQPkRKCC
K185-ub EPPETQPkRKCCIF_
- gap
- gap
  rat

 
T17 GDGAVGKTCLLISYT
S22 GKTCLLISYTTNKFP
Y23 KTCLLISYTTNKFPS
T24 TCLLISYTTNKFPSE
T25 CLLISYTTNKFPSEY
S30 YTTNKFPSEYVPTVF
Y32 TNKFPSEYVPTVFDN
Y32 TNKFPSEYVPTVFDN
T35 FPSEYVPTVFDNYAV
Y40 VPTVFDNYAVTVMIG
T43 VFDNYAVTVMIGGEP
Y51 VMIGGEPYTLGLFDT
T52 MIGGEPYTLGLFDTA
T58 YTLGLFDTAGQEDYD
Y64 DTAGQEDYDRLRPLS
S71 YDRLRPLSYPQTDVF
S88 CFSVVSPSSFENVKE
S89 FSVVSPSSFENVKEK
K96 SFENVKEKWVPEITH
K107 EITHHCPKTPFLLVG
K128 DDPSTIEKLAKNkQk
K133-ub IEKLAKNkQkPITPE
K135 KLAKNkQKPITPETA
K135-ub KLAKNkQkPITPETA
T141 QkPITPETAEkLARD
K144 ITPETAEKLARDLKA
K144-ub ITPETAEkLARDLKA
K153 ARDLKAVKYVECSAL
K153 ARDLKAVKYVECSAL
Y154 RDLKAVKYVECSALT
K163 ECSALTQKGLKNVFD
K166 ALTQKGLKNVFDEAI
- gap
- gap
K183 ALEPPEPKKSRRCVL
K184 LEPPEPKKSRRCVLL
  rabbit

 
T23 GDGAVGKTCLLISYT
S28 GKTCLLISYTTNKFP
Y29 KTCLLISYTTNKFPS
T30 TCLLISYTTNKFPSE
T31 CLLISYTTNKFPSEY
S36 YTTNKFPSEYVPTVF
Y38 TNKFPSEYVPTVFDN
Y38 TNKFPSEYVPTVFDN
T41 FPSEYVPTVFDNYAV
Y46 VPTVFDNYAVTVMIG
T49 VFDNYAVTVMIGGEP
Y57 VMIGGEPYTLGLFDT
T58 MIGGEPYTLGLFDTA
T64 YTLGLFDTAGQEDYD
Y70 DTAGQEDYDRLRPLs
S77-p YDRLRPLsYPQTDVF
S94 CFSVVSPSSFENVKE
S95 FSVVSPSSFENVKEK
K102 SFENVKEKWVPEITH
K113 EITHHCPKTPFLLVG
K134 DDPSTIEKLAKNKQK
K139 IEKLAKNKQKPITPE
K141 KLAKNKQKPITPETA
K141 KLAKNKQKPITPETA
T147 QKPITPETAEKLARD
K150 ITPETAEKLARDLKA
K150 ITPETAEKLARDLKA
K159 ARDLKAVKYVECSAL
K159 ARDLKAVKYVECSAL
Y160 RDLKAVKYVECSALT
K169 ECSALTQKGLKNVFD
K172 ALTQKGLKNVFDEAI
- gap
- gap
K189 ALEPPEPKKSRSIDL
K190 LEPPEPKKSRSIDLQ
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