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SPARC (human)

Overview SPARC Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. Belongs to the SPARC family. Note: This description may include information from UniProtKB. Protein type: Secreted; Secreted, signal peptide Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region; basement membrane; nucleus Molecular Function: collagen binding; protein binding; extracellular matrix binding; calcium ion binding Biological Process: response to peptide hormone stimulus; response to gravity; platelet activation; ossification; response to cAMP; heart development; response to glucocorticoid stimulus; response to lipopolysaccharide; signal transduction; response to L-ascorbic acid; regulation of cell proliferation; response to cadmium ion; platelet degranulation; response to ethanol; response to cytokine stimulus; response to lead ion; blood coagulation; response to calcium ion; inner ear development; lung development Reference #:  P09486 (UniProtKB) Alt. Names/Synonyms: Basement-membrane protein 40; BM-40; cysteine-rich protein; ON; Osteonectin; Secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin); SPARC; SPRC Gene Symbols: SPARC Molecular weight: 34,632 Da Basal Isoelectric point: 4.73  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SPARC 1BMO - A/B=71-303 (human) 1NUB - A/B=71-303 (human) 1SRA - A=153-303 (human) 2V53 - A=221-303 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1BMO 1NUB 1SRA 2V53  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y145-p	GHKLHLDyIGPCKYI

	mouse
Y144	GHKLHLDYIGPCKYI

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