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Protein Page:
SPARC (human)

Overview
SPARC Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. Belongs to the SPARC family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region; basement membrane; nucleus
Molecular Function: collagen binding; protein binding; extracellular matrix binding; calcium ion binding
Biological Process: platelet activation; response to gravity; response to peptide hormone stimulus; ossification; extracellular matrix organization and biogenesis; response to cAMP; heart development; response to glucocorticoid stimulus; response to lipopolysaccharide; signal transduction; response to L-ascorbic acid; regulation of cell proliferation; response to ethanol; response to cadmium ion; platelet degranulation; response to cytokine stimulus; response to lead ion; blood coagulation; response to calcium ion; inner ear development; lung development
Reference #:  P09486 (UniProtKB)
Alt. Names/Synonyms: Basement-membrane protein 40; BM-40; cysteine-rich protein; ON; Osteonectin; Secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin); SPARC; SPRC
Gene Symbols: SPARC
Molecular weight: 34,632 Da
Basal Isoelectric point: 4.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SPARC

Protein Structure Not Found.


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