|
SHH
Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Interacts with HHATL/GUP1 which negatively regulates HHAT-mediated palmitoylation of the SHH N-terminus. N-product is active as a multimer. Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues. Belongs to the hedgehog family. Note: This description may include information from UniProtKB.
|
| Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Cell cycle regulation |
|
Cellular Component: Golgi apparatus; extracellular matrix; extracellular space; transport vesicle; cell surface; endoplasmic reticulum; plasma membrane; nucleus; lipid raft
|
|
Molecular Function: laminin-1 binding; peptidase activity; morphogen activity; signal transducer activity; protein binding; glycosaminoglycan binding; zinc ion binding; patched binding; calcium ion binding; glycoprotein binding
|
|
Biological Process: skin development; prostate gland development; central nervous system development; positive regulation of transcription, DNA-dependent; embryonic skeletal development; telencephalon regionalization; embryonic foregut morphogenesis; male genitalia development; neural crest cell migration; inner ear development; embryonic limb morphogenesis; hindbrain development; positive regulation of neuroblast proliferation; tongue morphogenesis; camera-type eye development; neuron fate commitment; myotube differentiation; intermediate filament organization; response to organic nitrogen; osteoblast development; positive regulation of skeletal muscle cell proliferation; response to ethanol; positive regulation of photoreceptor cell differentiation; positive regulation of cell division; regulation of proteolysis; regulation of epithelial cell differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; neural tube formation; negative regulation of apoptosis; embryonic forelimb morphogenesis; axon guidance; ventral midline development; palate development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of striated muscle cell differentiation; Bergmann glial cell differentiation; negative regulation of T cell proliferation; pancreas development; forebrain development; positive regulation of cell proliferation; thyroid gland development; heart looping; vasculogenesis; ventral spinal cord interneuron specification; negative regulation of cell migration; positive thymic T cell selection; gut mesoderm development; intein-mediated protein splicing; androgen metabolic process; pattern specification process; odontogenesis of dentine-containing teeth; regulation of cell proliferation; embryonic development; negative regulation of cell differentiation; stem cell development; dorsal/ventral pattern formation; positive regulation of protein import into nucleus; ureteric bud branching; response to hypoxia; hindgut morphogenesis; lung development; negative regulation of alpha-beta T cell differentiation; heart development; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; T cell differentiation in the thymus; lymphoid progenitor cell differentiation; Wnt receptor signaling pathway through beta-catenin; embryonic pattern specification; proteolysis; anterior/posterior pattern formation; positive regulation of T cell differentiation in the thymus; cell-cell signaling; embryonic digestive tract morphogenesis; midbrain development; ectoderm development; positive regulation of smoothened signaling pathway; positive regulation of oligodendrocyte differentiation; oligodendrocyte development; activation of hh target transcription factor; endocytosis; positive regulation of skeletal muscle development; negative thymic T cell selection; patterning of blood vessels; branching morphogenesis of a tube; metanephros development; apoptosis; cell fate specification; embryonic hindlimb morphogenesis; response to estradiol stimulus; male genitalia morphogenesis; response to axon injury; positive regulation of Wnt receptor signaling pathway; dorsoventral neural tube patterning; organ formation; smoothened signaling pathway; hair follicle morphogenesis; response to retinoic acid; thymus development; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; positive regulation of immature T cell proliferation in the thymus; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; formation of anatomical boundary; myoblast differentiation; limb bud formation; establishment of cell polarity; neuroblast proliferation; blood coagulation; cell development; positive regulation of alpha-beta T cell differentiation
|
|
Reference #:
Q15465 (UniProtKB)
|
| Alt. Names/Synonyms: HHG-1; HHG1; HLP3; HPE3; MCOPCB5; SHH; SMMCI; sonic hedgehog homolog (Drosophila); Sonic hedgehog protein; Sonic hedgehog protein C-product; Sonic hedgehog protein N-product; TPT; TPTPS |
| Gene Symbols: SHH |
|
Molecular weight: 49,607 Da
|
|
Basal Isoelectric point: 8.09
Predict pI for various phosphorylation states
|
|
CST Pathways:
Hedgehog Signaling
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
