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AQP2 (human)

Overview AQP2 Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Channel, misc. Cellular Component: Golgi apparatus; recycling endosome; protein complex; rough endoplasmic reticulum; clathrin-coated vesicle; lysosome; basolateral plasma membrane; early endosome; apical plasma membrane; integral to membrane; plasma membrane; trans-Golgi network Molecular Function: water transporter activity; glycerol transmembrane transporter activity; water channel activity; actin binding; PDZ domain binding Biological Process: actin filament depolymerization; glycerol transport; response to glucagon stimulus; apoptosis; water transport; response to lithium ion; response to lipopolysaccharide; cellular response to water deprivation; female pregnancy; excretion; response to salt stress; response to starvation; renal water transport; hyperosmotic response; response to calcium ion; positive regulation of calcium ion transport; cell volume homeostasis; transmembrane transport; aging Reference #:  P41181 (UniProtKB) Alt. Names/Synonyms: ADH water channel; AQP-2; AQP-CD; AQP2; aquaporin 2 (collecting duct); Aquaporin-2; Aquaporin-CD; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; water-channel aquaporin 2; WCH-CD Gene Symbols: AQP2 Molecular weight: 28,837 Da Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below AQP2

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 107777 125800 222000  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
intracellular localization: S256‑p, K270‑u molecular association, regulation: S256‑p phosphorylation: K270‑u protein degradation: K270‑u

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		K228-u	YVLFPPAkSLSERLA
0	1		K238	SERLAVLKGLEPDTD
47	6		S256-p	REVRRRQsVELHsPQ
13	6		S261-p	RQsVELHsPQsLPRG
8	5		S264-p	VELHsPQsLPRGtkA
9	3		T269-p	PQsLPRGtkA_____
4	0		K270-u	QsLPRGtkA______

	mouse
K228	YLLFPSTKSLQERLA
K238-u	QERLAVLkGLEPDTD
S256-p	REVRRRQsVELHsPQ
S261-p	RQsVELHsPQsLPRG
S264-p	VELHsPQsLPRGsKA
S269-p	PQsLPRGsKA_____
K270	QsLPRGsKA______

	rat
K228	YLLFPSAKSLQERLA
K238	QERLAVLKGLEPDTD
S256-p	REVRRRQsVELHsPQ
S261-p	RQsVELHsPQsLPRG
S264-p	VELHsPQsLPRGskA
S269-p	PQsLPRGskA_____
K270-u	QsLPRGskA______

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