Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family. Note: This description may include information from UniProtKB.
Protein type: Transporter; Membrane protein, integral; Channel, misc.; Membrane protein, multi-pass; Transporter, aquaporin family
Cellular Component: recycling endosome; protein complex; clathrin-coated vesicle; membrane; rough endoplasmic reticulum; basolateral plasma membrane; lysosome; integral to plasma membrane; apical plasma membrane; early endosome; plasma membrane; trans-Golgi network
Molecular Function: water transporter activity; glycerol transmembrane transporter activity; water channel activity; actin binding; glycerol channel activity; PDZ domain binding
Biological Process: actin filament depolymerization; glycerol transport; response to glucagon stimulus; cellular water homeostasis; apoptosis; water transport; response to lithium ion; response to lipopolysaccharide; cellular response to water deprivation; female pregnancy; excretion; response to salt stress; response to starvation; renal water transport; hyperosmotic response; renal water homeostasis; positive regulation of calcium ion transport; response to calcium ion; transmembrane transport; aging
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.