Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Channel, misc.; Membrane protein, integral; Transporter; Transporter, aquaporin family
Cellular Component: Golgi apparatus; recycling endosome; membrane; integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane
Molecular Function: water transporter activity; glycerol transmembrane transporter activity; water channel activity; glycerol channel activity
Biological Process: glycerol transport; renal water transport; cellular water homeostasis; water transport; renal water homeostasis; cellular response to water deprivation; excretion; transmembrane transport
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.