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Protein Page:
AQP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AQP2 Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family. Note: This description may include information from UniProtKB.
Protein type: Transporter, aquaporin family; Membrane protein, multi-pass; Transporter; Channel, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q12-q13
Cellular Component: recycling endosome; protein complex; rough endoplasmic reticulum; membrane; clathrin-coated vesicle; basolateral plasma membrane; lysosome; early endosome; apical plasma membrane; integral to membrane; plasma membrane; trans-Golgi network
Molecular Function: water transporter activity; glycerol transmembrane transporter activity; water channel activity; actin binding; PDZ domain binding
Biological Process: glycerol transport; actin filament depolymerization; response to glucagon stimulus; apoptosis; water transport; response to lithium ion; response to lipopolysaccharide; cellular response to water deprivation; female pregnancy; excretion; response to salt stress; response to starvation; hyperosmotic response; renal water transport; cell volume homeostasis; response to calcium ion; positive regulation of calcium ion transport; transmembrane transport; aging
Reference #:  P41181 (UniProtKB)
Alt. Names/Synonyms: ADH water channel; AQP-2; AQP-CD; AQP2; aquaporin 2 (collecting duct); Aquaporin-2; Aquaporin-CD; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; water-channel aquaporin 2; WCH-CD
Gene Symbols: AQP2
Molecular weight: 28,837 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AQP2

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S256‑p, K270‑ub
molecular association, regulation: S256‑p
phosphorylation: K270‑ub
protein degradation: K270‑ub

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K228-ub YVLFPPAkSLSERLA
0 1 K238 SERLAVLKGLEPDTD
52 6 S256-p REVRRRQsVELHsPQ
16 6 S261-p RQsVELHsPQsLPRG
9 5 S264-p VELHsPQsLPRGtkA
13 3 T269-p PQsLPRGtkA_____
5 0 K270-ub QsLPRGtkA______
  mouse

 
K228 YLLFPSTKSLQERLA
K238-ub QERLAVLkGLEPDTD
S256-p REVRRRQsVELHsPQ
S261-p RQsVELHsPQsLPRG
S264-p VELHsPQsLPRGskA
S269-p PQsLPRGskA_____
K270-ub QsLPRGskA______
  rat

 
K228 YLLFPSAKSLQERLA
K238 QERLAVLKGLEPDTD
S256-p REVRRRQsVELHsPQ
S261-p RQsVELHsPQsLPRG
S264-p VELHsPQsLPRGskA
S269-p PQsLPRGskA_____
K270-ub QsLPRGskA______
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