Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family. Note: This description may include information from UniProtKB.
Protein type: Transporter; Transporter, aquaporin family; Membrane protein, multi-pass; Channel, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q12-q13
Cellular Component: recycling endosome; protein complex; rough endoplasmic reticulum; membrane; clathrin-coated vesicle; lysosome; basolateral plasma membrane; early endosome; apical plasma membrane; integral to membrane; plasma membrane; trans-Golgi network
Molecular Function: water transporter activity; glycerol transmembrane transporter activity; water channel activity; actin binding; PDZ domain binding
Biological Process: actin filament depolymerization; glycerol transport; response to glucagon stimulus; apoptosis; response to lithium ion; water transport; cellular response to water deprivation; response to lipopolysaccharide; female pregnancy; excretion; response to salt stress; response to starvation; renal water transport; hyperosmotic response; positive regulation of calcium ion transport; response to calcium ion; cell volume homeostasis; transmembrane transport; aging
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.