Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family. Note: This description may include information from UniProtKB.
Protein type: Transporter; Membrane protein, integral; Channel, misc.; Membrane protein, multi-pass; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 12q12-q13
Cellular Component: recycling endosome; protein complex; clathrin-coated vesicle; membrane; rough endoplasmic reticulum; lysosome; basolateral plasma membrane; early endosome; apical plasma membrane; integral to membrane; plasma membrane; trans-Golgi network
Molecular Function: water transporter activity; glycerol transmembrane transporter activity; actin binding; water channel activity; PDZ domain binding
Biological Process: glycerol transport; actin filament depolymerization; response to glucagon stimulus; apoptosis; response to lithium ion; water transport; response to lipopolysaccharide; cellular response to water deprivation; female pregnancy; excretion; response to salt stress; response to starvation; renal water transport; hyperosmotic response; response to calcium ion; cell volume homeostasis; positive regulation of calcium ion transport; transmembrane transport; aging
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.