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Protein Page:
14-3-3 beta (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
14-3-3 beta a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: transcriptional repressor complex; perinuclear region of cytoplasm; cytoplasm; melanosome; cytosol
Molecular Function: protein C-terminus binding; protein domain specific binding; protein binding; enzyme binding; histone deacetylase binding; phosphoprotein binding; transcription corepressor activity; phosphoserine binding
Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of catalytic activity; negative regulation of protein amino acid dephosphorylation; axon guidance; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; activation of MAPKK activity; apoptosis; MAPKKK cascade; mRNA metabolic process; RNA metabolic process; small GTPase mediated signal transduction; Ras protein signal transduction; cytoplasmic sequestering of protein; insulin receptor signaling pathway; gene expression; negative regulation of transcription, DNA-dependent; protein targeting
Reference #:  P31946 (UniProtKB)
Alt. Names/Synonyms: 14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha, N-terminally processed; 1433B; brain protein 14-3-3, beta isoform; GW128; HS1; KCIP-1; Protein 1054; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; YWHAB
Gene Symbols: YWHAB
Molecular weight: 28,082 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis  |  Cell Cycle: G2/M DNA Damage Checkpoint  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

14-3-3 beta
Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S186‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 2 T2-p ______MtMDKSELV
0 1 S6 __MtMDKSELVQkAk
0 30 K11-u DKSELVQkAkLAEQA
0 37 K13-u SELVQkAkLAEQAER
0 8 Y21-p LAEQAERyDDMAAAM
0 5 K29 DDMAAAMKAVtEQGH
0 1 T32-p AAAMKAVtEQGHELS
0 9 S47-p NEERNLLsVAykNVV
0 7 Y50-p RNLLsVAykNVVGAR
0 4 K51-a NLLsVAykNVVGARR
0 150 K51-u NLLsVAykNVVGARR
0 1 S59-p NVVGARRssWRVISs
5 10 S60-p VVGARRssWRVISsI
1 0 S65 RssWRVISsIEQkTE
0 2 S66-p ssWRVISsIEQkTER
0 3 K70-a VISsIEQkTERNEKK
0 23 K70-u VISsIEQkTERNEKK
0 1 K105-u DVLELLDkyLIPNAT
0 1 Y106-p VLELLDkyLIPNATQ
0 1 S116 PNATQPESkVFyLkM
0 26 K117-a NATQPESkVFyLkMk
0 1 K117-u NATQPESkVFyLkMk
0 1 Y120-p QPESkVFyLkMkGDy
0 4 K122-a ESkVFyLkMkGDyFR
0 72 K122-u ESkVFyLkMkGDyFR
0 10 K124-u kVFyLkMkGDyFRyL
0 5 Y127-p yLkMkGDyFRyLSEV
0 2 Y130-p MkGDyFRyLSEVASG
1 0 S132 GDyFRyLSEVASGDN
0 2 S136 RyLSEVASGDNkQTT
0 51 K140-u EVASGDNkQTTVSNS
1 0 T143 SGDNkQTTVSNSQQA
0 1 Y151-p VSNSQQAyQEAFEIS
0 1 K159-a QEAFEISkkEMQPTH
0 2 K159-u QEAFEISkkEMQPTH
0 54 K160-u EAFEISkkEMQPTHP
3 5 S186-p FYYEILNsPEKACSL
0 12 K195-u EKACSLAkTAFDEAI
0 1 T207-p EAIAELDtLNEESYK
  mouse

 
T2-p ______MtMDKsELV
S6-p __MtMDKsELVQkAk
K11-u DKsELVQkAkLAEQA
K13-u sELVQkAkLAEQAER
Y21 LAEQAERYDDMAAAM
K29-u DDMAAAMkAVTEQGH
T32 AAAMkAVTEQGHELS
S47-p NEERNLLsVAykNVV
Y50-p RNLLsVAykNVVGAR
K51-a NLLsVAykNVVGARR
K51-u NLLsVAykNVVGARR
S59 NVVGARRSsWRVISs
S60-p VVGARRSsWRVISsI
S65 RSsWRVISsIEQkTE
S66-p SsWRVISsIEQkTER
K70 VISsIEQKTERNEKK
K70-u VISsIEQkTERNEKK
K105 DVLELLDKYLILNAT
Y106 VLELLDKYLILNATQ
S116-p LNATQAEsKVFYLkM
K117 NATQAEsKVFYLkMk
K117 NATQAEsKVFYLkMk
Y120 QAEsKVFYLkMkGDY
K122-a EsKVFYLkMkGDYFR
K122-u EsKVFYLkMkGDYFR
K124-u KVFYLkMkGDYFRyL
Y127 YLkMkGDYFRyLSEV
Y130-p MkGDYFRyLSEVAsG
S132 GDYFRyLSEVAsGEN
S136-p RyLSEVAsGENkQTT
K140-u EVAsGENkQTTVSNS
T143 sGENkQTTVSNSQQA
Y151 VSNSQQAYQEAFEIS
K159 QEAFEISKkEMQPTH
K159-u QEAFEISkkEMQPTH
K160-u EAFEISkkEMQPTHP
S186 FYYEILNSPEKACSL
K195-u EKACSLAkTAFDEAI
T207 EAIAELDTLNEESYK
  rat

 
T2 ______MTMDKSELV
S6 __MTMDKSELVQkAk
K11-u DKSELVQkAkLAEQA
K13-u SELVQkAkLAEQAER
Y21-p LAEQAERyDDMAAAM
K29-u DDMAAAMkAVTEQGH
T32 AAAMkAVTEQGHELS
S47 NEERNLLSVAYkNVV
Y50 RNLLSVAYkNVVGAR
K51 NLLSVAYKNVVGARR
K51-u NLLSVAYkNVVGARR
S59 NVVGARRSsWRVIsS
S60-p VVGARRSsWRVIsSI
S65-p RSsWRVIsSIEQkTE
S66 SsWRVIsSIEQkTER
K70 VIsSIEQKTERNEKK
K70-u VIsSIEQkTERNEKK
K105 DVLELLDKYLILNAT
Y106 VLELLDKYLILNATH
S116 LNATHAESKVFYLkM
K117 NATHAESKVFYLkMK
K117 NATHAESKVFYLkMK
Y120 HAESKVFYLkMKGDY
K122 ESKVFYLKMKGDYFR
K122-u ESKVFYLkMKGDYFR
K124 KVFYLkMKGDYFRYL
Y127 YLkMKGDYFRYLsEV
Y130 MKGDYFRYLsEVASG
S132-p GDYFRYLsEVASGDN
S136 RYLsEVASGDNkQTt
K140-u EVASGDNkQTtVSNS
T143-p SGDNkQTtVSNSQQA
Y151 VSNSQQAYQEAFEIS
K159 QEAFEISKKEMQPTH
K159 QEAFEISKKEMQPTH
K160 EAFEISKKEMQPTHP
S186-p FYYEILNsPEKACSL
K195 EKACSLAKTAFDEAI
T207 EAIAELDTLNEESYK
  sheep

 
T2 ______MTMDKSELV
S6 __MTMDKSELVQKAK
K11 DKSELVQKAKLAEQA
K13 SELVQKAKLAEQAER
Y21 LAEQAERYDDMAAAM
K29 DDMAAAMKAVTEQGH
T32 AAAMKAVTEQGHELS
S47 NEERNLLSVAYKNVV
Y50 RNLLSVAYKNVVGAR
K51 NLLSVAYKNVVGARR
K51 NLLSVAYKNVVGARR
S59 NVVGARRSSWRVISS
S60 VVGARRSSWRVISSI
S65 RSSWRVISSIEQKTE
S66 SSWRVISSIEQKTER
K70 VISSIEQKTERNEKK
K70 VISSIEQKTERNEKK
- gap
- gap
- gap
- gap
- gap
- gap
K85 QQMGKEYKMKGDYFR
K85 QQMGKEYKMKGDYFR
K87 MGKEYKMKGDYFRYL
Y90 EYKMKGDYFRYLSEV
Y93 MKGDYFRYLSEVASG
S95 GDYFRYLSEVASGDN
S99 RYLSEVASGDNKQTT
K103 EVASGDNKQTTVSNS
T106 SGDNKQTTVSNSQQA
Y114 VSNSQQAYQEAFEIS
K122 QEAFEISKKEMQPTH
K122 QEAFEISKKEMQPTH
K123 EAFEISKKEMQPTHP
S149-p FYYEILNsPEAIAEL
- gap
T158 EAIAELDTLNEESYK
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